STUDY OF PLASMA NEUROPEPTIDE Y (NPY) AND CATECHOLAMINES LEVELS DURING ISOFLURANE ANESTHESIA

研究Isoflurane麻醉對血中NPY及Catecholamines濃度之影嚮

張傳林(Chuan-Lin Chang)；林世祥(Shih-Shyang Lin)；曾稼志(Chia-Chih Tzeng)；葉富欽(Fuh-Cheng Yeh)；賴裕永(Yeng-Yuh Lai)；黃顯哲(Shen-Jer Hwang)；梁百安(Pak-On Leung)；蘇浩博(Haw-Po Su)；鄭瑞棠(Juei-Tang Cheng)

Neuropeptide Y (NPY) ； Catecholamine Inhalation (Forane)

Acta Anaesthesiologica Sinica

28卷3期（1990 / 09 / 01）

265 - 271

英文

Twelve ASA physical status I-II patients were studied after obtaining institutional approval and informed contents. All patients were free from endocrine and metabolic disease undergoing elective low risk operation. Pethidine 1 mg/kg i.m. and benzodiazepine 0.01 mg/kg p.o. were given as premedication one hour before anesthesia. Anesthesia was induced with thiopental 4 mg/kg and succinylcholine 1.5 mg/kg for tracheal intubation. Anesthesia was maintained with 2% isoflurane and 50% N_2O in oxygen. Ventilation was controlled and adjusted to maintain an end-tidal CO_2 concentration of 25-35 torr. Atracurium 0.4 mg/kg was given as muscle relaxant. Blood samples were obtained from radial arterial catheter, 15 minutes before induction of anesthesia and 5 min after anesthesia, 15 min, 30 min, 60 min during operation and 30 min after operation in postanesthesia recovery room. The results showed that there were no statistically significant changes in plasma levels of NPY and catecholamines during operation underwent isoflurane anesthetic technique. This result indicates that isoflurane anesthesia can block the plasma NPY as well as catecholamines during surgical stress.

不同之麻醉技術或不同之麻醉劑，可誘發不同之血中NPY及Catecholamines濃度反應，對某些手術中病人有不良之影嚮，已知高劑量fentanyl及spinal anesthesia可抑制此種不良反應，但isoflurane麻醉對血中NPY之影嚮尚未見報告，本研究以12位ASAI-II的病人用2%isoflurane與N_2O-O_2（50%）作全身麻醉於下肢及下腹部之常規手術，在一定之時間內抽血測定NPY及Catecholamines之濃度與手術前比較，結果：在手術過程中，不論NPY或Catecholamines之變化均無統計學上意義，顯示在本實驗中適當之isoflurane麻醉濃度亦可抑制血中NPY及Catecholamines之不良反應。