GENERAL ANESTHESIA WITH PROPOFOL (CONTINUOUS INTRAVENOUS INFUSION) SUPPLEMENTED WITH NITROUS OXIDE: COMPARISON WITH ISOFLURANE

以Propofol連續靜脈滴注配合N_2O進行全身麻醉：與Isoflurane比較

黃芳彥(Fan-Yen Huang)；黃慧薰(Huang Hui-Hsun)；劉健強(Kien-Cuong Lun)；林祐生(Lin Youh-Shen)；王明鉅(Wang Ming-Jiuh)；林昭傑(Chao-Chieh Lin)；侯文詠(Wen-Yeong Hou)；陳欽隆(Chin-Long Chen)；李宗勲(Lee Tzong Shiun)；趙繼慶(Chi-Ching Chao)

Propofol ； Isoflurane ； Continuous infusion ； Recovery time

Acta Anaesthesiologica Sinica

28卷3期（1990 / 09 / 01）

273 - 278

英文

Thirty adult surgical patients (ASA I-II) undergoing superficial operations of short duration (about 1h) were arbitrarily divided into two groups. In group A (n=15), anethesia was induced with propofol, 2 mg/kg, iv. After endotracheal intubation with the aid of succinylcholine (1 mg/kg, iv), anesthesia was maintained by continuous iv infusion of propofol (0.05-0.2 mg/kg/min) with nitrous oxide and oxygen (2:1). In group B (n=15), induction and endotracheal intubation were accomplished using thiopental (4 mg/kg, iv) and succinylcholine (1 mg/kg). Anesthesia was maintained with isoflurane (0.5-2.0%), nitrous oxide and oxygen (2:1). Atracuriurn was used in both group s as muscle relaxant. Hemodynamic responses to laryngoscopy and endotracheal intubation and during operation were not significantly different between the two groups. However, recovery to verbal command and orientation was significantly more rapid in the propofol group (7.8±4.8 min and 11.2±5.1 min) than in the isoflurane group (15.6±4.9 min and 22.6±6.0 min). In conclusion, continuous propofol infusion combined with nitrous oxide and muscle relaxant is suggested as a better method compared with isoflurane for short operations because of more rapid complete recovery.

三十位接受約一小時手術的ASA Class I-II成年病人隨機分作A、B兩組。A組十五人以propofol 2 mg/kg，Succinylcholine 1 mg/kg導入麻醉及作插管後以Propofol 0.1-0.2 mg/kg/min連續靜脈滴注加上N_2O:O_2（2:1）維持麻醉。B組十五人以Thiopental 4mg/kg，Succinylcholine 1 mg/kg導入麻醉及作插管後以isoflurane 0.5-2%加上N_2O:O_2（2:1）維持麻醉。兩組手術中均使用AtracurIum維持手術所需肌肉鬆弛。比較兩組在插管及手術過程中心跳血壓的變化，並無顯著的差異。手術後比較兩組清醒的速度（定向感的恢復及對言語的反應），結果發現Propofol組的病人比Isoflurane組的清醒速度較快。