Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia

Li-Jie Zhang；Sheau-Farn Yeh；Ya-Ten Yu；Li-Ming Yang Kuo；Yao-Haur Kuo

Rotala rotundifolia ； Flavonol glucuronides ； Anti-HBsAg ； Anti-oxidative activity

Journal of Traditional and Complementary Medicine

1卷1期（2011 / 10 / 01）

57 - 63

英文

Two new flavonol glucuronides, quercetin 3-O-β-D-2＂-acetylglucuronide (1) and quercetin 3-O-β -D-2＂- acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of various spectroscopic methods, including 1D and 2D NMR techniques. Biological evaluation showed that all of isolated flavonoid compounds have potent anti-oxidative activities by DPPH and superoxide anion methods, and kaempferol (3) and quercetin (4) exhibited significant anti-HBV activity assayed by anti-HBsAg production. The HPLC fingerprint with photodiode array detection (HPLC-DAD) for quality control of R. rotundifolia partitioned EtOAc layer was also established.

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