题名

Beneficial Effects of Cinnamon on the Metabolic Syndrome, Inflammation, and Pain, and Mechanisms Underlying These Effects - A Review

作者

Yan Shen;Liu-Nan Jia;Natsumi Honma;Takashi Hosono;Toyohiko Ariga;Taiichiro Seki

关键词

Cinnamon ; Spice ; Diabetes ; Metabolic syndrome ; Inflammation ; Insulin

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

2卷1期(2012 / 01 / 01)

页次

27 - 32

内容语文

英文

中文摘要

Cinnamon is one of the most important herbal drugs and has been widely used in Asia for more than 4000 years. As a folk medicine, cinnamon has been traditionally applied to the treatment of inflammatory disorders and gastric diseases. After chemical profiling of cinnamon's components, their biological activities including antimicrobial, antiviral, antioxidant, antitumor, antihypertension, antilipemic, antidiabetes, gastroprotective and immunomodulatory were reported by many investigators. As a result, current studies have been performed mostly focusing on the bioactivity of cinnamon toward the recently generalized metabolic syndrome involving diabetes. In this review article, we provide an overview of the recent literature describing cinnamon's potential for preventing the metabolic syndrome.

主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Abraham, S.K.,Singh, S.P.,Kesavan, P.C.(1998).In vivo antigenotoxic effects of dietary agents and beverages co-administered with urethane: assessment of the role of glutathione S-transferase activity.Mutat Res,413,103-110.
  2. Altschuler, J.A.,Casella, S.J.,MacKenzie, T.A.,Curtis, K.M.(2007).The effect of cinnamon on A1C among adolescents with type 1 diabetes.Diabetes Care,30,813-816.
  3. Anderson, R.A.,Broadhurst, C.L.,Polansky, M.M.,Schmidt, W.F.,Khan, A.,Flanagan, V.P.,Schoene, N.W.,Graves, D.J.(2004).Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity.J Agric Food Chem,52,65-70.
  4. Berrio, L.F.,Polansky, M.M.,Anderson, R.A.(1992).Insulin activity: stimulatory effects of cinnamon and brewer’s yeast as influenced by albumin.Horm Res,37,225-229.
  5. Blevins, S.M.,Leyva, M. J.,Brown, J.,Wright, J.,Scofiekd, R.H.,Aston, C.E.(2007).Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes.Diabetes Care,30,2236-2237.
  6. Broadhurst, C.L.,Polansky, M.M.,Anderson, R.A.(2000).Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro.J Agric Food Chem,48,849-852.
  7. Cao, H.,Polansky, M.M.,Anderson, R.A.(2007).Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes.Arch Biochem Biophys,459,214-222.
  8. Chase, C.K.,McQueen, C.E.(2007).Cinnamon in diabetes mellitus.Am J Health Syst Pharm,64,1033-1035.
  9. Chen, Y.(1981).Pharmacological studies of Cinnamomum cassia bark. Part I. Effects on the blood and cardiovascular system.Zhong Yao Tong Bao,6,32-34.
  10. Cheng, B.C.(1983).A review of cinnamon.Zhong Cao Yao,14,134.
  11. Chericoni, S.,Prieto, J.M.,Iacopini, P.,Cioni, P.,Morelli, I.(2005).In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes.J Agric Food Chem,53,4762-4765.
  12. Desmet, PAGM(ed.)(1992).Adverse effect of herbal drugs.Berlin:Springer-Verlag.
  13. Dragland, S.,Senoo, H.,Wake, K.,Holte, K.,Blomhoff, R.(2003).Several culinary and medicinal herbs are important sources of dietary antioxidants.J Nutr,133,1286-1290.
  14. Gowda, D.C.,Sarathy, C.(1987).Structure of an L-arabino-D- xylan from the bark of Cinnamomum zeylanicum.Carbohydrate Res,166,263-269.
  15. Harada, M.,Fujii, Y.,Kamiya, J.(1976).Pharmacological studies on Chinese cinnamon. III. Electroencephalographic studies of cinnamaldehyde in the rabbit.Chem Phar Bull,24,1784-1788.
  16. Harada, M.,Ozaki, Y.(1972).Pharmacological studies on Chinese cinnamon. I. Central effects of cinnamaldehyde.Yakugaku Zasshi,92,135-140.
  17. Harada, M.,Yano, S.(1975).Pharmacological studies on Chinese cinammon. II. Effects of cinnamaldehyde on the cardiovascular and digestive systems.Chem Pharm Bull,23,941-947.
  18. Hayashi, K.,Imanishi, N.,Kashiwayama, Y.,Kawano, A.,Terasawa, K.,Shimada, Y.,Ochiai, H.(2007).Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo.Antiviral Res,74,1-8.
  19. Imparl-Radosevich, J.,Deas, S.,Polansky, M.M.,Baedke, D.A.,Ingebritsen, T.S.,Anderson, R.A.,Graves, D.J.(1998).Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signaling.Horm Res,50,177-182.
  20. Isogai, A.,Murakoshi, S.,Suzuki, A.,Tamura, S.(1977).Chemistry and biological activities of cinnzeylanine and cinnzeylanol, new insecticidal substances from Cinnamonum zeylanicum nees.Agric Biol Chem,41,1779-1784.
  21. Iwasaki, Y.,Tanabe, M.,Kobata, K.,Watanabe, T.(2008).TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion.Biosci Biotechnol Biochem,72,2608-2614.
  22. Jarvill-Taylor, K.J.,Anderson, R.A.,Graves, D.J.(2001).A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes.J Am Coll Nutr,20,327-336.
  23. Ka, H.,Park, H.J.,Jung, H.J.,Choi, J.W.,Cho, K.S.,Ha, J.,Lee, K.T.(2003).Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells.Cancer Lett,196,143-152.
  24. Kannappan, S.,Jayaraman, T.,Rajasekar, P.,Ravichandtan, M.K.,Anuradha, C.V.(2006).Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat.Singapore Med J,47,858-863.
  25. Khan, A.,Bryden, N.A.,Polansky, M.M.,Anderson, R.A.(1990).Insulin potentiating factor and chromium content of selected foods and spices.Biol Trace Elem Res,24,183-188.
  26. Khan, A.,Safdar, M.,Ali Khan, M.M.,Khattak, K.N.,Anderson, R.A.(2003).Cinnamon improves glucose and lipids of people with type 2 diabetes.Diabetes Care,26,3215-3218.
  27. Kim, S.H.,Hyun, S.H.,Choung, S.Y.(2006).Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice.J Ethnopharmacol,104,119-123.
  28. Kim, W.,Khil, L. Y.,Clark, R.,Bok, S.H.,Kim, E.E.,Lee, S.,Jun, H.S.,Yoon, J.W.(2006).Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4.Diabetologia,49,2437-2448.
  29. Koh, W.S.,Yoon, S.Y.,Kown, B.M.(1998).Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.Int J Immunopharmacol,20,643-660.
  30. Kreydiyyeh, S.I.,Usta, J.,Copti, R.(2000).Effect of cinnamon, clove and some of their constituents on the Na(+)-K(+)-ATPase activity and alanine absorption in the rat jejunum.Food Chem Toxicol,38,755-762.
  31. Lee, C.W.,Hing, D.H.,Han, S.B.(1999).Inhibition of human tumor growth by 2’- hydroxyl- and 2’- benzoloxycinnamaldehyde.Planta Med,65,263-266.
  32. Lee, T.,Dugoua, J.J.(2011).Nutritional supplements and their effect on glucose control.Curr Diab Rep,11,142-148.
  33. Lima, E.O.,Gompertz, O.F.,Giesbrecht A.M.,Paulo, M.Q.(1993).In vitro antifungal activity of essential oils obtained from officinal plants against dermatophytes.Mycoses,36,333-336.
  34. Mancini-Filho, J.,Van-Koiij, A.,Mancini, D.A.,Cozzolino, F.F.,Torres, R.P.(1998).Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts.Boll Chim Farm,137,443-447.
  35. Mang, B.,Wolters, M.,Schmitt, B.,Kelb, K.,Lichtinghagen, R.,Stichtenoth, D.O.,Hahn, A.(2006).Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.Eur J Clin Invest,36,340-344.
  36. Nagai, H.,Shimazawa, T.,Matsuura, N.,Koda, A.(1982).Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq). I. Anti-allergic action.Jpn J Pharmacol,32,813-822.
  37. Nagai, H.,Shimazawa, T.,Takizawa, T.,Koda, A.,Yagi, A.,Nishioka, I.(1982).Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.Jpn J Pharmacol,32,823-831.
  38. Nagai, H.,Takizawa, T.,Nishiyori, T.,Koda, A.(1982).Experimental glomerulonephritis in mice as a model for immunopharmacological studies.Jpn J Pharmacol,32,1117-1124.
  39. Nishida, S.,Kikuichi, S.,Yoshioka, S.,Tsubaki, M.,Fujii, Y.,Matsuda, H.,Kubo, M.,Irimajiri, K.(2003).Induction of apoptosis in HL-60 cells treated with medicinal herbs.Am J Chin Med,31,551-562.
  40. Okawa, M.,Kinjo, J.,Nohara, T.,Ono, M.(2001).DPPH (1,1-diphenyl-2- picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants.Biol Pharm Bull,24,1202-1205.
  41. Onderoglu, S.,Sozer, S.,Erbil, K. M.,Ortac, R.,Lermioglu, F.(1999).The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats.J Pharm Pharmacol,51,1305-1312.
  42. Pham, A.Q.,Kourlas, H.,Pham, D.Q.(2007).Cinnamon supplementation in patients with type 2 diabetes mellitus.Pharmacotherapy,27,595-599.
  43. Premanathan, M.,Rajendran, S.,Ramanathan, T.,Kathiresan, K.,Nakashima, H.,Yamamoto, N.(2000).A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity.Indian J Med Res,112,73-77.
  44. Preuss, H.G.,Echard, B.,Polansky, M.M.,Anderson, R.(2006).Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats.J Am Coll Nutr,25,144-150.
  45. Qin, B.,Nagasaki, M.,Ren, M.,Bajotto, G.,Oshida, Y.,Sato, Y.(2004).Cinnamon extract prevents the insulin resistance induced by a high-fructose diet.Horm Metab Res,36,119-125.
  46. Qin, B.,Nagasaki, M.,Ren, M.,Bajotto, G.,Oshida, Y.,Sato, Y.(2003).Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats.Diabetes Res Clin Pract,62,139-148.
  47. Quale, J.M.,Landman, D.,Zaman, M.M.,Burney, S.,Sathe, S.S.(1996).In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis.Am J Chin Med,24,103-109.
  48. Roffey, B.,Atwal, A.,Kubow, S.(2006).Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells.Mol Nutr Food Res,50,739-745.
  49. Schoene, N.W.,Kelly, M.A.,Polansky, M.M.,Anderson, R.A.(2005).Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines.Cancer Lett,230,134-140.
  50. Shen, Y.,Fukushima, M.,Ito, Y.,Muraki, E.,Hosono, T.,Seki, T.,Ariga, T.(2010).Verification of antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes.Biosci Biotec Biochem,74,2418-2425.
  51. Shobana, S.,Naidu, K.A.(2000).Antioxidant activity of selected Indian spices.Prostaglandins Leukot Essent Fatty Acids,62,107-110.
  52. Singh, H.B.,Srivastava, M.,Singh, A.B.,Srivastava, A.K.(1995).Cinnamon bark oil, a potent fungitoxicant against fungi causing respiratory tract mycoses.Allergy,50,995-999.
  53. Su, M.J.,Chen, W.P.,Lo, T.Y.,Wu, T.S.(1999).Ionic mechanisms for the antiarrhythmic action of cinnamophilin in rat heart.J Biomed Sci,6,376-386.
  54. Subash Babu, P.,Prabuseenivasan, S.,Ignacimuthu, S.(2007).Cinnamaldehyde-a potential antidiabetic agent.Phytomedicine,14,15-22.
  55. Suppapitiporn, S.,Kanpaksi, N.,Suppapitiporn, S.(2006).The effect of cinnamon cassia powder in type 2 diabetes mellitus.J Med Assoc Thai,89,S200-S205.
  56. Tabak, M.,Armon, R.,Neeman, I.(1999).Cinnamon extracts’ inhibitory effect on Helicobacter pylori.J Ethnopharmacol,67,269-277.
  57. Taher, M.,Abdul Majid, F.A.,Sarmidi, M.R.(2004).Cinnamtannin B1 activity on adipocyte formation.Med J Malaysia,59(Suppl B),97-98.
  58. Talpur, N.,Echard, B.,Ingram, C.,Bagchi, D.,Preuss, H.(2005).Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study.Diabetes Obes Metab,7,193-199.
  59. Terasawa, K.,Kimura, M.,Sakuragawa, N.,Uchiyama, Y.,Toriizuka, K.,Ueno, M.,Horikoshi, I.(1983).Effects of anti-"Oketsu" drugs on blood coagulation and fibrinolysis.Yakugaku Zasshi,103,313-318.
  60. Vanschoonbeek, K.,Thomassen, B.J.,Senden, J.M.,Wodzig, W.K.,van Loon, L.J.(2006).Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients.J Nutr,136,977-980.
  61. Verspohl, E.J.,Bauer, K.,Neddermann, E.(2005).Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro.Phytother Res,19,203-206.
  62. Wang, J.G.,Anderson, R.A.,Graham, G.M., III.,Chu, M.C.,Sauer, M.V.,Guarnaccia, M. M.,Lobo, R.A.(2007).The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study.Fertil Steril,88,240-243.
  63. Yu, S.M.,Ko, F.N.,Wu, T.S.,Lee, J.Y.(1994).Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense.Eur J Pharmacol,256,85-91.
  64. Yu, S.M.,Wu, T.S.,Teng, C.M.(1994).Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor.Br J Pharmacol,111,906-912.
  65. Zhou, L.,Chen, Z.X.,Chen, J.Y.(1995).Effect of wu lin powder and its ingredients on atrial natriuretic factor level in mice.Zhongguo Zhong Xi Yi Jie He Za Zhi,15,36-37.
被引用次数
  1. Tippaporn Bualeong,Thanika Pathomwichaiwat,Sasipong Tipratchadaporn,Krongkarn Chootip,Anjaree Inchan(2022).Anti-hypotensive effect of "Yahom Navakot" in rats with orthostatic hypotension.Journal of Traditional and Complementary Medicine,12(2),180-189.