题名

Protective Effects of Antrodia Cinnamomea Against Liver Injury

作者

Yen-Wenn Liu;Kuan-Hung Lu;Chi-Tang Ho;Lee-Yan Sheen

关键词

Antrodia Cinnamomea ; Fruiting bodies ; Mycelia ; Liver injury

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

2卷4期(2012 / 10 / 01)

页次

284 - 294

内容语文

英文

中文摘要

Chinese herbal medicine (中草藥) attracts much attention in the treatment of liver injuries. Numerous studies have revealed various biological activities of medicinal mushrooms such as Antrodia Cinnamomea (牛樟芝). Although A. cinnamomea is rare in the wild, recent developments in fermentation and cultivation technologies make the mycelia and fruiting bodies of this valuable medicinal mushroom readily available. Liver diseases such as fatty liver, hepatitis, hepatic fibrosis, and liver cancer are complicated processes of liver injuries that have tremendous impact on human society. In this article, we reviewed studies about the hepatoprotective effects of the fruiting bodies and mycelia of A. cinnamomea performed in different experimental models. The results of those studies suggest the potential application of A. cinnamomea in preventing and treating liver diseases and its potential to be developed into health foods or new drugs.

主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Achliya, G.S.,Wadodkar, S.G.,Dorle, A.K.(2004).Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats.J Ethnopharmacol,90,229-232.
  2. Ao, Z.H.,Xu, Z.H.,Lu, Z.M.,Xu, H.Y.,Zhang, X.M.,Dou, W.F.(2009).Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.J Ethnopharmacol,121,194-212.
  3. Baraona, E.,Lieber, C.S.(1979).Effects of ethanol on lipid metabolism.J Lipid Res,20,289-315.
  4. Chen, C.C.,Liu, Y.W.,Ker, Y.B.,Wu, Y.Y.,Lai, E.Y.,Chyau, C.C.,Hseu, T.H.,Peng, R.Y.(2007).Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia.J Agric Food Chem,55,5007-5012.
  5. Chiang, P.C.,Lin, S.C.,Pan, S.L.,Kuo, C.H.,Tsai, I.L.,Kuo, M.T.,Wen, W.C.,Chen, P.,Guh, J.H.(2010).Antroquinonol displays anticancer potential against human hepatocellualr carcinoma cells: a crucial role of AMPK and mTOR pathway.Biochem Pharmacol,79,162-171.
  6. Christofori, G.(2006).New signals from the invasive front.Nature,441,444-450.
  7. Cronholm, T.,Jones, A.W.,Skagerberg, S.(1988).Mechanism and regulation of ethanol elimination in humans: intermolecular hydrogen transfer and oxidoreduction in vivo.Alcohol Clin Exp Res,12,683-686.
  8. Day, C.P.,Yeaman, S.J.(1994).The biochemistry of alcohol-induced fatty liver.Biochim Biophys Acta,1215,33-48.
  9. Du, Y.C.,Chang, F.R.,Wu, T.Y.,Hsu, Y.M.,El-Shazly, M.,Chen, C.F.,Sung, P.J.,Lin, Y.Y.,Lin, Y.H.,Wu, Y.C.,Lu, M.C.(2012).Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.Phytomedicine,19,788-796.
  10. Friedman, S.L.(1997).Molecular mechanisms of hepatic fibrosis and principles of therapy.J Gastroenterol,32,424-430.
  11. Galli, A.,Pinaire, J.,Fischer, M.,Dorris, R.,Crabb, D.W.(2001).The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.J Biol Chem,276,68-75.
  12. Gao, B.,Bataller, R.(2011).Alcoholic liver disease: pathogenesis and new therapeutic targets.Gastroenterology,141,1572-1585.
  13. Hemmann, S.,Graf, J.,Roderfeld, M.,Roeb, E.(2007).Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies.J Hepatol,46,955-975.
  14. Hoekstra, L.T.,de Graaf, W.,Nibourg, G.A.,Heger, M.,Bennink, R.J.,Stieger, B.,van Gulik, T.M(2012).Physiological and biochemical basis of clinical liver function tests: A Review.Ann Surg,2012
  15. Hofmann, U.B.,Houben, R.,Brocker, E.B.,Becker, J.C.(2005).Role of matrix metalloproteinases in melanoma cell invasion.Biochimie,87,307-314.
  16. Horiguchi, N.,Wang, L.,Mukhopadhyay, P.,Park, O.,Jeong, W.I.,Lafdil, F.,Osei-Hyiaman, D.,Moh, A.,Fu, X.Y.,Pacher, P.,Kunos, G.,Gao, B.(2008).Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.Gastroenterology,134,1148-1158.
  17. Hseu, Y.C.,Chen, S.C.,Yech, Y.J.,Wang, L.,Yang, H.L.(2008).Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage.J Ethnopharmacol,118,237-245.
  18. Hsiao, G.,Shen, M.Y.,Lin, K.H.,Lan, M.H.,Wu, L.Y.,Chou, D.S.,Lin, C.H.,Su, C.H.,Sheu, J.R.(2003).Antioxidative and hepatoprotective effects of Antrodia camphorata extract.J Agric Food Chem,51,3302-3308.
  19. Hsieh, Y.C.,Rao, Y.K.,Whang-Peng, J.,Huang, C.Y.,Shyue, S.K.,Hsu, S.L.,Tzeng, Y.M.(2011).Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.J Agric Food Chem,59,10943-10954.
  20. Hsieh, Y.C.,Rao, Y.K.,Wu, C.C.,Huang, C.Y.,Geethangili, M.,Hsu, S.L.,Tzeng, Y.M.(2010).Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.Chem Res Toxicol,23,1256-1267.
  21. Hsu, Y.L.,Kuo, P.L.,Cho, C.Y.,Ni, W.C.,Tzeng, T.F.,Ng, L.T.,Kuo, Y.H.,Lin, C.C.(2007).Antrodia Cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway.Food Chem Toxicol,45,1249-1257.
  22. Hsu, Y.L.,Kuo, Y.C.,Kuo, P.L.,Ng, L.T.,Kuo, Y.H.,Lin, C.C.(2005).Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.Cancer Lett,221,77-89.
  23. Huang, C.H.,Chang, Y.Y.,Liu, C.W.,Kang, W.Y.,Lin, Y.L.,Chang, H.C.,Chen, Y.C.(2010).Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.J Agric Food Chem,58,3859-3866.
  24. Huang, G.J.,Huang, S.S.,Lin, S.S.,Shao, Y.Y.,Chen, C.C.,Hou, W.C.,Kuo, Y.H.(2010).Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice.J Agric Food Chem,58,7445-7452.
  25. Jeong, W.I.,Park, O.,Gao, B.(2008).Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis.Gastroenterology,134,248-258.
  26. Jiménez-López, J.M.,Carrasco, M.P.,Segovia, J.L.,Marco, C.(2002).Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospholipid metabolism.Biochem Pharmacol,63,1485-1490.
  27. Knittel, T.,Mehde, M.,Grundmann, A.,Saile, B.,Scharf, J.G.,Ramadori, G.(2000).Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat.Histochem Cell Biol,113,443-453.
  28. Kumar, K.J.,Chu, F.H.,Hsieh, H.W.,Liao, J.W.,Li, W.H.,Lin, J.C.,Shaw, J.F.,Wang, S.Y.(2011).Antroquinonol from ethanolic extract of mycelium of Antrodia Cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.J Ethnopharmacol,136,168-177.
  29. Lieber, C.S.,Jones, D.P.,Mendelson, J.,DeCarli, L.M.(1963).Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake.Trans Assoc Am Physicians,76,289-300.
  30. Lin, Y.W.,Chiang, B.H.(2011).4-acetylantroquinonol B isolated from Antrodia Cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels.J Agric Food Chem,59,8625-8631.
  31. Lin, Y.W.,Pan, J.H.,Liu, R.H.,Kuo, Y.H.,Sheen, L.Y.,Chiang, B.H.(2010).The 4-acetylantroquinonol B isolated from mycelium of Antrodia Cinnamomea inhibits proliferation of hepatoma cells.J Sci Food Agric,90,1739-1744.
  32. Lu, Z.M.,Tao, W.Y.,Xu, H.Y.,Ao, Z.H.,Zhang, X.M.,Xu, Z.H.(2011).Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats.Nat Prod Res,25,684-695.
  33. Lu, Z.M.,Tao, W.Y.,Zou, X.L.,Fu, H.Z.,Ao, Z.H.(2007).Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.J Ethnopharmacol,110,160-164.
  34. Marrero, J.A.(2006).Hepatocellular carcinoma.Curr Opin. Gastroenterol,22,248-253.
  35. Nakamura, N.,Hirakawa, A.,Gao, J.J.,Kakuda, H.,Shiro, M.,Koma tsu, Y.,Sheu, C.C.,Hattori, M.(2004).Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.J Nat Prod,67,46-48.
  36. Shao, Y.Y.,Chen, C.C.,Wang, H.Y.,Chiu, H.L.,Hseu, T.H.,Kuo, Y.H.(2008).Chemical constituents of Antrodia camphorate submerged whole broth.Nature Product Research,22,1151-1157.
  37. Sharma, H.S.,Kilpatrick, M.,Lyons, G.(2005).Prediction of potential mushroom yield by visible and near-infrared spectroscopy using fresh phase II compost.Appl Spectrosc,59,1054-1059.
  38. Shen, C.C.,Wang, Y.H.,Chang, T.T.,Lin, L.C.,Don, M.J.,Hou, Y.C.,Liou, K.T.,Chang, S.,Wang, W.Y.,Ko, H.C.,Shen, Y.C.(2007).Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea.Planta Med,73,1208-1213.
  39. Shen, Y.C.,Wang, Y.H.,Chou, Y.C.,Chen, C.F.,Lin, L.C.,Chang, T.T.,Tien, J.H.,Chou, C.J.(2004).Evaluation of the antiinflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata.Planta Med,70,310-314.
  40. Song, T.Y.,Hsu, S.L.,Yeh, C.T.,Yen, G.C.(2005).Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.J Agric Food Chem,53,5559-5564.
  41. Song, T.Y.,Hsu, S.L.,Yeh, G.C.(2005).Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture.J Ethnopharmacol,100,158-167.
  42. Tipoe, G.L.,Leung, T.M.,Liong, E.C.,Lau, T.Y.,Fung, M.L.,Nanji, A.A.(2010).Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice.Toxicology,273,45-52.
  43. Tu, S.H.,Wu, C.H.,Chen, L.C.,Huang, C.S.,Chang, H.W.,Chang, C.H.,Lien, H.M.,Ho, Y.S.(2012).In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from The fruiting body of Antrodia camphorata through activation of The p53-mediated p27/Kip1 signaling pathway.J Agric Food Chem,60,3612-3618.
  44. Wong, F.W.,Chan, W.Y.,Lee, S.S.(1998).Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression.Toxicol Appl Pharmacol,153,109-118.
  45. Wu, M.F.,Peng, F.C.,Chen, Y.L.,Lee, C.S.,Yang, Y.Y.,Yeh, M.Y.,Liu, C.M.,Chang, J.B.,Wu, R.S.,Yu, C.C.,Lu, H.F.,Chung, J.G.(2011).Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test.In Vivo,25,419-423.
  46. Xiao, J.,Liong, E.C.,Ching, Y.P.,Chang, R.C.,So, K.F.,Fung, M.L.,Tipoe, G.L.(2012).Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation.J Ethnopharmacol,139,462-470.
  47. Yoon, J.H.,Gores, G.J.(2002).Death receptor-mediated apoptosis and the liver.Hepatology,37,400-410.
  48. You, M.,Liang, X.,Ajmo, J.M.,Ness, G.C.(2008).Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.Am J Physiol Gastrointest Liver Physiol,294,G892-G898.
  49. You, M.,Matsumoto, M.,Pacold, C.M.,Cho, W.K.,Crabb, D.W.(2004).The role of AMP-activated protein kinase in the action of ethanol in the liver.Gastroenterology,127,1798-1808.
  50. You, M.,Rogers, C.Q.(2009).Adiponectin: a key adipokine in alcoholic fatty liver.Exp Biol Med,234,850-859.
被引用次数
  1. Yi-Chun Pan,Lee-Yan Sheen,Kuan-Hung Lu(2020).Combination of cut-log cultivated fruiting body and solid-state cultured mycelia of Taiwanofungus camphoratus ameliorates CCl_4-induced liver injury in rats.Journal of Traditional and Complementary Medicine,10(2),166-174.
  2. 趙文婉,陳銹萍,李璨聿(2020)。綜論:牛樟芝活性成分之藥理活性。中醫藥雜誌,31(2),1-27。