题名

Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants

DOI

10.4103/2225-4110.124811

作者

Yue-Hu Wang；Susan L. Morris-Natschke；Jun Yang；Hong-Mei Niu；Chun-Lin Long；Kuo-Hsiung Lee

关键词

Amide alkaloids ； Anticancer ； Cytotoxicity ； Piper ； Piperaceae

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

4卷1期（2014 / 01 / 01）

页次

8 - 16

内容语文

英文
中文摘要

The ethnomedical uses of Piper (胡椒 Hú Jiāo) plants as anticancer agents, in vitro cytotoxic activity of both extracts and compounds from Piper plants, and in vivo antitumor activity and mechanism of action of selected compounds are reviewed in the present paper. The genus Piper (Piperaceae) contains approximately 2000 species, of which 10 species have been used in traditional medicines to treat cancer or cancer-like symptoms. Studies have shown that 35 extracts from 24 Piper species and 32 compounds from Piper plants possess cytotoxic activity. Amide alkaloids account for 53% of the major active principles. Among them, piplartine (piperlongumine) shows the most promise, being toxic to dozens of cancer cell lines and having excellent in vivo activity. It is worthwhile to conduct further anticancer studies both in vitro and in vivo on Piper plants and their active principles.
主题分类 醫藥衛生 > 中醫藥學
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被引用次数
  1. Vikas Kumar,Vaishali Yadav,Shyam Sunder Chatterjee,Muhammed Majeed(2016).Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain.Journal of Traditional and Complementary Medicine,6(4),413-423.
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