题名

Dietary Agents and Phytochemicals in the Prevention and Treatment of Experimental Ulcerative Colitis

DOI

10.4103/2225-4110.139111

作者

Arpit Saxena；Kamaljeet Kaur；Shweta Hegde；Faizan M Kalekhan；Manjeshwar Shrinath Baliga；Raja Fayad

关键词

Cancer ； Colitis ； Colon ； Inflammation ； Phytochemicals

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

4卷4期（2014 / 10 / 01）

页次

203 - 217

内容语文

英文
中文摘要

Inflammatory bowel diseases (IBDs), consisting mainly of ulcerative colitis (UC) and Crohn's disease (CD), are important immune-mediated diseases of the gastrointestinal tract. The etiology of the disease includes environmental and genetic factors. Its management presents a constant challenge for gastroenterologists and conventional surgeon. 5-Amninosalicylates, antibiotics, steroids, and immune modulators have been used to reduce the symptoms and for maintenance of remission. Unfortunately, long-term usage of these agents has been found to lead to severe toxicities, which are deterrent to the users. Pre-clinical studies carried out in the recent past have shown that certain dietary agents, spices, oils, and dietary phytochemicals that are consumed regularly possess beneficial effects in preventing/ameliorating UC. For the first time, this review addresses the use of these dietary agents and spices in the treatment and prevention of IBD and also emphasizes on the mechanisms responsible for their effects.
主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Abboud, PA,Hake, PW,Burroughs, TJ,Odoms, K,O’Connor, M,Mangeshkar, P(2008).Therapeutic effect of epigallocatechin‑3‑gallate in a mouse model of colitis.Eur J Pharmacol,579,411-417.
  2. Abdallah, DM,Ismael, NR(2011).Resveratrol abrogates adhesion molecules and protects against TNBS‑induced ulcerative colitis in rats.Can J Physiol Pharmacol,89,811-818.
  3. Abdullaev, FI(2002).Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.).Exp Biol Med,227,20-25.
  4. Ali, BH,Blunden, G,Tanira, MO,Nemmar, A(2008).Some phytochemical, pharmacological and toxicological properties of ginger(Zingiber officinale Roscoe): A review of recent research.Food Chem Toxicol,46,409-420.
  5. Andujar, I,Recio, MC,Giner, RM,Cienfuegos‑Jovellanos, E,Laghi, S,Muguerza, B(2011).Inhibition of ulcerative colitis in mice after oral administration of a polyphenol‑enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.J Agric Food Chem,59,6474-6483.
  6. Antony, ML,Singh, SV(2011).Molecular mechanisms and targets of cancer chemoprevention by garlic‑derived bioactive compound diallyl trisulfide.Indian J Exp Biol,49,805-816.
  7. Arafa, HM,Hemeida, RA,El‑Bahrawy, AI,Hamada, FM(2009).Prophylactic role of curcumin in dextran sulfate sodium (DSS)‑induced ulcerative colitis murine model.Food Chem Toxicol,47,1311-1317.
  8. Azuma, T,Shigeshiro, M,Kodama, M,Tanabe, S,Suzuki, T(2013).Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice.J Nutr,143,827-834.
  9. Balentine, DA,Wiseman, SA,Bouwens, LC(1997).The chemistry of tea flavonoids.Crit Rev Food Sci Nutr,37,693-704.
  10. Baliga, MS,Bhat, HP,Pereira, MM,Mathias, N,Venkatesh, P(2010).Radioprotective effects of Aegle marmelos(L.) Correa (Bael): A concise review.J Altern Complement Med,16,1109-1116.
  11. Baliga, MS,Dsouza, JJ(2011).Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer.Eur J Cancer Prev,20,225-239.
  12. Baliga, MS,Haniadka, R,Pereira, MM,D’Souza, JJ,Pallaty, PL,Bhat, HP(2011).Update on the chemopreventive effects of ginger and its phytochemicals.Crit Rev Food Sci Nutr,51,499-523.
  13. Baliga, MS,Haniadka, R,Pereira, MM,Thilakchand, KR,Rao, S,Arora, R(2012).Radioprotective effects of Zingiber officinale Roscoe (ginger): Past, present and future.Food Funct,3,714-723.
  14. Baliga, MS,Joseph, N,Venkataranganna, MV,Saxena, A,Ponemone, V,Fayad, R(2012).Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: Preclinical and clinical observations.Food Funct,3,1109-1117.
  15. Barzegar, A,Moosavi‑Movahedi, AA(2011).Intracellular ROS protection efficiency and free radical‑scavenging activity of curcumin.PLoS One,6,e26012.
  16. Basch, E,Ulbricht, C,Kuo, G,Szapary, P,Smith, M(2003).Therapeutic applications of fenugreek.Altern Med Rev,8,20-27.
  17. Basu, A,Betts, NM,Mulugeta, A,Tong, C,Newman, E,Lyons, TJ(2013).Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome.Nutr Res,33,180-187.
  18. Behera, JP,Mohanty, B,Ramani, YR,Rath, B,Pradhan, S(2012).Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease.Indian J Pharmacol,44,614-618.
  19. Bhandary, B,Lee, GH,Marahatta, A,Lee, HY,Kim, SY,So, BO(2012).Water extracts of immature Rubus coreanus regulate lipid metabolism in liver cells.Biol Pharm Bull,35,1907-1913.
  20. Biedermann, L,Mwinyi, J,Scharl, M,Frei, P,Zeitz, J,Kullak‑Ublick, GA(2013).Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis ‑ An open pilot study.J Crohns Colitis,7,271-279.
  21. Bogdanski, P,Suliburska, J,Szulinska, M,Stepien, M,Pupek‑Musialik, D,Jablecka, A(2012).Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.Nutr Res,32,421-427.
  22. Bongiorno, PB,Fratellone, PM,LoGiudice, P(2008).Potential Health Benefits of Garlic (Allium Sativum): ANarrative Review.Journal of Complementary and Integrative Medicine,5
  23. Borrelli, F,Capasso, R,Russo, A,Ernst, E(2004).Systematic review: Green tea and gastrointestinal cancer risk.Aliment Pharmacol Ther,19,497-510.
  24. Bouzid, D,Gargouri, B,Mansour, RB,Amouri, A,Tahri, N,Lassoued, S(2013).Oxidative stress markers in intestinal mucosa of Tunisian inflammatory bowel disease patients.Saudi J Gastroenterol,19,131-135.
  25. Boyer, J,Liu, RH(2004).Apple phytochemicals and their health benefits.Nutr J,3,5.
  26. Brahmbhatt, M,Gundala, SR,Asif, G,Shamsi, SA,Aneja, R(2013).Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation.Nutr Cancer,65,263-272.
  27. Brijesh, S,Daswani, P,Tetali, P,Antia, N,Birdi, T(2009).Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage.BMC Complement Altern Med,9,47.
  28. Bruckner, M,Westphal, S,Domschke, W,Kucharzik, T,Lugering, A(2012).Green tea polyphenol epigallocatechin‑3‑gallate shows therapeutic antioxidative effects in a murine model of colitis.J Crohns Colitis,6,226-235.
  29. Calani, L,Dall’Asta, M,Derlindati, E,Scazzina, F,Bruni, R,Del Rio, D(2012).Colonic metabolism of polyphenols from coffee, green tea, and hazelnut skins.J Clin Gastroenterol,46(Suppl),S95-S99.
  30. Calderon‑Montano, JM,Burgos‑Moron, E,Perez‑Guerrero, C,Lopez‑Lazaro, M(2011).A review on the dietary flavonoid kaempferol.Mini Rev Med Chem,11,298-344.
  31. Camacho‑Barquero, L,Villegas, I,Sanchez‑Calvo, JM,Talero, E,Sanchez‑Fidalgo, S,Motilva, V(2007).Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX‑2 and iNOS expression in chronic experimental colitis.Int Immunopharmacol,7,333-342.
  32. Canter, PH,Ernst, E(2004).Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision‑A systematic review of placebo‑controlled trials.Surv Ophthalmol,49,38-50.
  33. Cardeno, A,Sanchez‑Hidalgo, M,de la Lastra, AC(2013).An up‑date of olive oil phenols in inflammation and cancer: Molecular mechanisms and clinical implications.Curr Med Chem
  34. Cheah, KY,Bastian, SE,Acott, TM,Abimosleh, SM,Lymn, KA,Howarth, GS(2013).Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium‑induced colitis in rats.Dig Dis Sci,58,970-977.
  35. Chen, D,Chen, MS,Cui, QC,Yang, H,Dou, QP(2007).Structure‑proteasome‑inhibitory activity relationships of dietary flavonoids in human cancer cells.Front Biosci,12,1935-1945.
  36. Chen, YC,Shen, SC,Lin, HY(2003).Rutinoside at C7 attenuates the apoptosis‑inducing activity of flavonoids.Biochem Pharmacol,66,1139-1150.
  37. Cicerale, S,Lucas, LJ,Keast, RS(2012).Antimicrobial, antioxidant and anti‑inflammatory phenolic activities in extra virgin olive oil.Curr Opin Biotechnol,23,129-135.
  38. Ciprofloxacin. label, 01/13. http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/019537s081,020780s039lbl.pdf.
  39. Coelho, RC,Hermsdorff, HH,Bressan, J(2013).Anti‑inflammatory properties of orange juice: Possible favorable molecular and metabolic effects.Plant Foods Hum Nutr,68,1-10.
  40. Cruz, T,Galvez, J,Ocete, MA,Crespo, ME,Sanchez de Medina, LHF,Zarzuelo, A(1998).Oral administration of rutoside can ameliorate inflammatory bowel disease in rats.Life Sci,62,687-695.
  41. Cui, X,Jin, Y,Hofseth, AB,Pena, E,Habiger, J,Chumanevich, A(2010).Resveratrol suppresses colitis and colon cancer associated with colitis.Cancer Prev Res,3,549-559.
  42. D’Arena, G,Simeon, V,De Martino, L,Statuto, T,D’Auria, F,Volpe, S(2013).Regulatory T‑cell modulation by green tea in chronic lymphocytic leukemia.Int J Immunopathol Pharmacol,26,117-125.
  43. D’Argenio, G,Mazzone, G,Tuccillo, C,Ribecco, MT,Graziani, G,Gravina, AG(2012).Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.Dig Liver Dis,44,555-562.
  44. Darvesh, AS,Bishayee, A(2013).Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer.Nutr Cancer,65,329-344.
  45. Davalli, P,Rizzi, F,Caporali, A,Pellacani, D,Davoli, S,Bettuzzi, S(2012).Anticancer activity of green tea polyphenols in prostate gland.Oxid Med Cell Longev,2012,984219.
  46. Deguchi, Y,Andoh, A,Inatomi, O,Yagi, Y,Bamba, S,Araki, Y(2007).Curcumin prevents the development of dextran sulfate Sodium (DSS)‑induced experimental colitis.Dig Dis Sci,52,2993-2998.
  47. Deshmukh, CD,Veeresh, B,Pawar, AT(2010).Protective effect of Emblica Officinalis fruit extract on acetic acid induced colitis in rats.Journal of Herbal Medicine and Toxicology,4,83-87.
  48. dos Reis, SB,de Oliveira, CC,Acedo, SC,Miranda, DD,Ribeiro, ML,Pedrazzoli, J, Jr.(2009).Attenuation of colitis injury in rats using Garcinia cambogia extract.Phytother Res,23,324-329.
  49. El‑Abhar, HS,Hammad, LN,Gawad, HS(2008).Modulating effect of ginger extract on rats with ulcerative colitis.J Ethnopharmacol,118,367-372.
  50. Elisabetta, B,Flavia, G,Paolo, F,Giorgio, L,Attilio, SG,Fiorella, LS(2013).Nutritional profile and productivity of bilberry (Vaccinium myrtillus L.) in different habitats of a protected area of the eastern Italian Alps.J Food Sci,78,C673-C678.
  51. Filocamo, A,Nueno‑Palop, C,Bisignano, C,Mandalari, G,Narbad, A(2012).Effect of garlic powder on the growth of commensal bacteria from the gastrointestinal tract.Phytomedicine,19,707-711.
  52. Firenzuoli, F,Gori, L,Lombardo, G(2008).The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco‑Toxicological Problems.Evid Based Complement Alternat Med,5,3-15.
  53. Forland, DT,Johnson, E,Saetre, L,Lyberg, T,Lygren, I,Hetland, G(2011).Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn’s disease.Scand J Immunol,73,66-75.
  54. Gonzalez‑Barrio, R,Edwards, CA,Crozier, A(2011).Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: In vivo and in vitro studies.Drug Metab Dispos,39,1680-1688.
  55. Gould, J,Vieira, J,Wolf, B(2013).Cocoa particles for food emulsion stabilisation.Food Funct,4,1369-1375.
  56. Grinde, B,Hetland, G,Johnson, E(2006).Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection.Int Immunopharmacol,6,1311-1314.
  57. Grzanna, R,Lindmark, L,Frondoza, CG(2005).Ginger‑‑an herbal medicinal product with broad anti‑inflammatory actions.J Med Food,8,125-132.
  58. Guazelli, CF,Fattori, V,Colombo, BB,Georgetti, SR,Vicentini, FT,Casagrande, R(2013).Quercetin‑loaded microcapsules ameliorate experimental colitis in mice by anti‑inflammatory and antioxidant mechanisms.J Nat Prod,76,200-208.
  59. Gupta, SC,Patchva, S,Aggarwal, BB(2013).Therapeutic roles of curcumin: Lessons learned from clinical trials.AAPS J,15,195-218.
  60. Gursel, FE,Ates, A,Bilal, T,Altiner, A(2012).Effect of dietary Garcinia cambogia extract on serum essential minerals (calcium, phosphorus, magnesium) and trace elements (iron, copper, zinc) in rats fed with high‑lipid diet.Biol Trace Elem Res,148,378-382.
  61. Gutheil, WG,Reed, G,Ray, A,Anant, S,Dhar, A(2012).Crocetin: An agent derived from saffron for prevention and therapy for cancer.Curr Pharm Biotechnol,13,173-179.
  62. Hanai, H,Sugimoto, K(2009).Curcumin has bright prospects for the treatment of inflammatory bowel disease.Curr Pharm Des,15,2087-2094.
  63. Harisa, GE,Abo-Salem, OM,El-Sayed el, SM,Taha, EI,El-Halawany, N(2009).L-arginine augments the antioxidant effect of garlic against acetic acid-induced ulcerative colitis in rats.Pak J Pharm Sci,22,373-380.
  64. Harris, JC,Cottrell, SL,Plummer, S,Lloyd, D(2001).Antimicrobial properties of Allium sativum (garlic).Appl Microbiol Biotechnol,57,282-286.
  65. He, J,Wallace, TC,Keatley, KE,Failla, ML,Giusti, MM(2009).Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat.J Agric Food Chem,57,3141-3148.
  66. Hilsden, RJ,Verhoef, MJ,Best, A,Pocobelli, G(2003).Complementary and alternative medicine use by Canadian patients with inflammatory bowel disease: Results from a national survey.Am J Gastroenterol,98,1563-1568.
  67. Huang, CH,Ku, CY,Jan, TR(2009).Diosgenin attenuates allergen‑induced intestinal inflammation and IgE production in a murine model of food allergy.Planta Med,75,1300-1305.
  68. Hungin, AP,Whorwell, PJ,Tack, J,Mearin, F(2003).The prevalence, patterns and impact of irritable bowel syndrome: An international survey of 40,000 subjects.Aliment Pharmacol Ther,17,643-650.
  69. Hyson, DA(2011).A comprehensive review of apples and apple components and their relationship to human health.Adv Nutr,2,408-420.
  70. Inoue, H,Akiyama, S,Maeda‑Yamamoto, M,Nesumi, A,Tanaka, T,Murakami, A(2011).High‑dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium‑induced colitis mice by down‑regulation of antioxidant enzymes and heat‑shock protein expressions.Cell Stress Chaperones,16,653-662.
  71. Itzkowitz, SH,Yio, X(2004).Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation.Am J Physiol Gastrointest Liver Physiol,287,G7-G17.
  72. Jena, G,Trivedi, PP,Sandala, B(2012).Oxidative stress in ulcerative colitis: an old concept but a new concern.Free Radic Res,46,1339-1345.
  73. Jiang, H,Deng, CS,Zhang, M,Xia, J(2006).Curcumin‑attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase‑2.World J Gastroenterol,12,3848-3853.
  74. Juan, ME,Alfaras, I,Planas, JM(2012).Colorectal cancer chemoprevention by trans‑resveratrol.Pharmacol Res,65,584-591.
  75. Kamalipour, M,Akhondzadeh, S(2011).Cardiovascular effects of saffron: An evidence‑based review.J Tehran Heart Cent,6,59-61.
  76. Kaneko, T,Shimpo, K,Chihara, T,Beppu, H,Tomatsu, A,Shinzato, M(2012).Inhibition of ENNG‑induced pyloric stomach and small intestinal carcinogenesis in mice by high temperature‑ and pressure‑treated garlic.Asian Pac J Cancer Prev,13,1983-1988.
  77. Karimi, E,Oskoueian, E,Hendra, R,Jaafar, HZ(2010).Evaluation of Crocus sativus L. stigma phenolic and flavonoid compounds and its antioxidant activity.Molecules,15,6244-6256.
  78. Kazi, HA,Qian, Z(2009).Crocetin reduces TNBS‑induced experimental colitis in mice by downregulation of NFkB.Saudi J Gastroenterol,15,181-187.
  79. Ke, F,Yadav, PK,Ju, LZ(2012).Herbal medicine in the treatment of ulcerative colitis.Saudi J Gastroenterol,18,3-10.
  80. Kim, J,Kyung, J,Kim, D,Choi, EK,Bang, P,Park, D(2012).Anti‑obesity effects of Rapha diet (R) preparation in mice fed a high‑fat diet.Lab Anim Res,28,265-271.
  81. Kim, M,Murakami, A,Miyamoto, S,Tanaka, T,Ohigashi, H(2010).The modifying effects of green tea polyphenols on acute colitis and inflammation‑associated colon carcinogenesis in male ICR mice.Biofactors,36,43-51.
  82. Kodera, Y,Ichikawa, M,Yoshida, J,Kashimoto, N,Uda, N,Sumioka, I(2002).Pharmacokinetic study of allixin, a phytoalexin produced by garlic.Chem Pharm Bull,50,354-363.
  83. Krishnaswamy, K(2008).Traditional Indian spices and their health significance.Asia Pac J Clin Nutr,17(Suppl 1),265-268.
  84. Krishnaveni, M,Mirunalini, S(2010).Therapeutic potential of Phyllanthus emblica (amla): The ayurvedic wonder.J Basic Clin Physiol Pharmacol,21,93-105.
  85. Kumar, A,Prakash, A,Dogra, S(2011).Protective effect of curcumin (Curcuma longa) against D‑galactose‑induced senescence in mice.JAsian Nat Prod Res,13,42-55.
  86. Kwon, KH,Murakami, A,Tanaka, T,Ohigashi, H(2005).Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium‑induced experimental colitis in mice: Attenuation of pro‑inflammatory gene expression.Biochem Pharmacol,69,395-406.
  87. Lakatos, PL,Miheller, P(2010).Is there an increased risk of lymphoma and malignancies under anti‑TNF therapy in IBD?.Curr Drug Targets,11,179-186.
  88. Lampe, JW(2003).Spicing up a vegetarian diet: Chemopreventive effects of phytochemicals.Am J Clin Nutr,78,579S-583S.
  89. Larmonier, CB,Uno, JK,Lee, KM,Karrasch, T,Laubitz, D,Thurston, R(2008).Limited effects of dietary curcumin on Th‑1 driven colitis in IL‑10 deficient mice suggest an IL‑10‑dependent mechanism of protection.Am J Physiol Gastrointest Liver Physiol,295,G1079-G1091.
  90. Lee, JS,Hong, EK(2011).Agaricus blazei Murill enhances doxorubicin‑induced apoptosis in human hepatocellular carcinoma cells by NFkappaB‑mediated increase of intracellular doxorubicin accumulation.Int J Oncol,38,401-408.
  91. Li, XL,Cai, YQ,Qin, H,Wu, YJ(2008).Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS‑induced ulcerative colitis.Can J Physiol Pharmacol,86,841-849.
  92. Lin, YZ,Chen, Y,Song, YG(2007).Protective effect of epigallocatechin‑3‑gallate on inflammatory bowel disease: Experiment with rat models of induced colitis.Zhonghua Yi Xue Za Zhi,87,2965-2968.
  93. Liu, L,Liu, YL,Liu, GX,Chen, X,Yang, K,Yang, YX(2013).Curcumin ameliorates dextran sulfate sodium‑induced experimental colitis by blocking STAT3 signaling pathway.Int Immunopharmacol,17,314-320.
  94. Loor Solorzano, RG,Fouet, O,Lemainque, A,Pavek, S,Boccara, M,Argout, X(2012).Insight into the wild origin, migration and domestication history of the fine flavour Nacional Theobroma cacao L. variety from Ecuador.PLoS One,7,e48438.
  95. Lubbad, A,Oriowo, MA,Khan, I(2009).Curcumin attenuates inflammation through inhibition of TLR‑4 receptor in experimental colitis.Mol Cell Biochem,322,127-135.
  96. Magrone, T,Perez de Heredia, F,Jirillo, E,Morabito, G,Marcos, A,Serafini, M(2013).Functional foods and nutraceuticals as therapeutic tools for the treatment of diet‑related diseases.Can J Physiol Pharmacol,91,387-396.
  97. Mahendran, P,Devi, CS(2001).Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats.Indian J Physiol Pharmacol,45,345-350.
  98. Maity, P,Hansda, D,Bandyopadhyay, U,Mishra, DK(2009).Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos(L.) Corr.Indian J Exp Biol,47,849-861.
  99. Marquez, F,Babio, N,Bullo, M,Salas‑Salvado, J(2012).Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans.Crit Rev Food Sci Nutr,52,585-594.
  100. Mashhadi, NS,Ghiasvand, R,Askari, G,Hariri, M,Darvishi, L,Mofid, MR(2013).Anti‑oxidative and anti‑inflammatory effects of ginger in health and physical activity: Review of current evidence.Int J Prev Med,4,S36-S42.
  101. Mazzon, E,Muia, C,Paola, RD,Genovese, T,Menegazzi, M,De Sarro, A(2005).Green tea polyphenol extract attenuates colon injury induced by experimental colitis.Free Radic Res,39,1017-1025.
  102. Mehta, SJ,Silver, AR,Lindsay, JO(2013).Review article: Strategies for the management of chronic unremitting ulcerative colitis.Aliment Pharmacol Ther,38,77-97.
  103. Monagas, M,Khan, N,Andres‑Lacueva, C,Casas, R,Urpi‑Sarda, M,Llorach, R(2009).Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.Am J Clin Nutr,90,1144-1150.
  104. Montrose, DC,Horelik, NA,Madigan, JP,Stoner, GD,Wang, LS,Bruno, RS(2011).Anti‑inflammatory effects of freeze‑dried black raspberry powder in ulcerative colitis.Carcinogenesis,32,343-350.
  105. Mouzaoui, S,Rahim, I,Djerdjouri, B(2012).Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)‑alpha‑induced oxidative stress, colitis and hepatotoxicity in mice.Int Immunopharmacol,12,302-311.
  106. Mukherjee, S,Lekli, I,Goswami, S,Das, DK(2009).Freshly crushed garlic is a superior cardioprotective agent than processed garlic.JAgric Food Chem,57,7137-7144.
  107. Murakami, A,Furukawa, I,Miyamoto, S,Tanaka, T,Ohigashi, H(2013).Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation‑associated mouse colon carcinogenesis.Biofactors,39,221-232.
  108. Murakami, A,Hayashi, R,Tanaka, T,Kwon, KH,Ohigashi, H,Safitri, R(2003).Suppression of dextran sodium sulfate‑induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: Separately and in combination.Biochem Pharmacol,66,1253-1261.
  109. Nagib, MM,Tadros, MG,ElSayed, MI,Khalifa, AE(2013).Anti‑inflammatory and anti‑oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats.Toxicol Appl Pharmacol,271,106-113.
  110. Nassiri‑Asl, M,Hosseinzadeh, H(2009).Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds.Phytother Res,23,1197-1204.
  111. Ng, KT,Guo, DY,Cheng, Q,Geng, W,Ling, CC,Li, CX(2012).A garlic derivative, S‑allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma.PLoS One,7,e31655.
  112. Nones, K,Dommels, YE,Martell, S,Butts, C,McNabb, WC,Park, ZA(2009).The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene‑deficient (mdr1a‑/‑) mice, a model of inflammatory bowel diseases.Br J Nutr,101,169-181.
  113. Ogawa, Y,Kanatsu, K,Iino, T,Kato, S,Jeong, YI,Shibata, N(2002).Protection against dextran sulfate sodium‑induced colitis by microspheres of ellagic acid in rats.Life Sci,71,827-839.
  114. Oz, HS,Chen, T,de Villiers, WJ(2013).Green Tea Polyphenols and Sulfasalazine have Parallel Anti‑Inflammatory Properties in Colitis Models.Front Immunol,4,132.
  115. Oz, HS,Chen, TS,McClain, CJ,de Villiers, WJ(2005).Antioxidants as novel therapy in a murine model of colitis.J Nutr Biochem,16,297-304.
  116. Padilha, MM,Avila, AA,Sousa, PJ,Cardoso, LG,Perazzo, FF,Carvalho, JC(2009).Anti‑inflammatory activity of aqueous and alkaline extracts from mushrooms(Agaricus blazei Murill).J Med Food,12,359-364.
  117. Park, MY,Ji, GE,Sung, MK(2012).Dietary kaempferol suppresses inflammation of dextran sulfate sodium‑induced colitis in mice.Dig Dis Sci,57,355-363.
  118. Perez‑Berezo, T,Ramirez‑Santana, C,Franch, A,Ramos‑Romero, S,Castellote, C,Perez‑Cano, FJ(2012).Effects of a cocoa diet on an intestinal inflammation model in rats.Exp Biol Med,237,1181-1188.
  119. Perez‑Cano, FJ,Massot‑Cladera, M,Franch, A,Castellote, C,Castell, M(2013).The effects of cocoa on the immune system.Front Pharmacol,4,71.
  120. Pezzuto, JM(2008).Grapes and human health: A perspective.JAgric Food Chem,56,6777-6784.
  121. Podolsky, DK(2002).Inflammatory bowel disease.NEngl J Med,347,417-429.
  122. Poiana, MA,Alexa, E,Mateescu, C(2012).Tracking antioxidant properties and color changes in low‑sugar bilberry jam as effect of processing, storage and pectin concentration.Chem Cent J,6,4.
  123. Rahal, K,Schmiedlin‑Ren, P,Adler, J,Dhanani, M,Sultani, V,Rittershaus, AC(2012).Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan‑polysaccharide rat model of Crohn’s disease.Inflamm Bowel Dis,18,613-623.
  124. Rahimi, R,Shams‑Ardekani, MR,Abdollahi, M(2010).A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease.World J Gastroenterol,16,4504-4514.
  125. Raju, J,Patlolla, JM,Swamy, MV,Rao, CV(2004).Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane‑induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT‑29 human colon cancer cells.Cancer Epidemiol Biomarkers Prev,13,1392-1398.
  126. Ramirez‑Sanchez, I,Taub, PR,Ciaraldi, TP,Nogueira, L,Coe, T,Perkins, G(2013).(‑)‑Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients.Int J Cardiol
  127. Renugadevi, J,Prabu, SM(2010).Cadmium‑induced hepatotoxicity in rats and the protective effect of naringenin.Exp Toxicol Pathol,62,171-181.
  128. Rezaee, R,Hosseinzadeh, H(2013).Safranal: From an aromatic natural product to a rewarding pharmacological agent.Iran J Basic Med Sci,16,12-26.
  129. Riegsecker, S,Wiczynski, D,Kaplan, MJ,Ahmed, S(2013).Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis.Life Sci,93,307-312.
  130. Romano, M,Vitaglione, P,Sellitto, S,D’Argenio, G(2012).Nutraceuticals for protection and healing of gastrointestinal mucosa.Curr Med Chem,19,109-117.
  131. Salh, B,Assi, K,Templeman, V,Parhar, K,Owen, D,Gomez‑Munoz, A(2003).Curcumin attenuates DNB‑induced murine colitis.Am J Physiol Gastrointest Liver Physiol,285,G235-G243.
  132. Sanchez de Medina, F,Vera, B,Galvez, J,Zarzuelo, A(2002).Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat.Life Sci,70,3097-3108.
  133. Sanchez‑Fidalgo, S,Cardeno, A,Sanchez‑Hidalgo, M,Aparicio‑Soto, M,de la Lastra, CA(2013).Dietary extra virgin olive oil polyphenols supplementation modulates DSS‑induced chronic colitis in mice.J Nutr Biochem,24,1401-1413.
  134. Sanchez‑Fidalgo, S,Cardeno, A,Sanchez‑Hidalgo, M,Aparicio‑Soto, M,Villegas, I,Rosillo, MA(2012).Dietary unsaponifiable fraction from extra virgin olive oil supplementation attenuates acute ulcerative colitis in mice.Eur J Pharm Sci,48,572-581.
  135. Sanchez‑Fidalgo, S,Cardeno, A,Villegas, I,Talero, E,de la Lastra, CA(2010).Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.Eur J Pharmacol,633,78-84.
  136. Sanchez‑Fidalgo, S,Sanchez de Ibarguen, L,Cardeno, A,Alarcon de la Lastra, C(2012).Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model.Eur J Nutr,51,497-506.
  137. Sanchez‑Fidalgo, S,Villegas, I,Cardeno, A,Talero, E,Sanchez‑Hidalgo, M,Motilva, V(2010).Extra‑virgin olive oil‑enriched diet modulates DSS‑colitis‑associated colon carcinogenesis in mice.Clin Nutr,29,663-673.
  138. Schmidt, M,Betti, G,Hensel, A(2007).Saffron in phytotherapy: Pharmacology and clinical uses.Wien Med Wochenschr,157,315-319.
  139. Seril, DN,Liao, J,Yang, GY,Yang, CS(2003).Oxidative stress and ulcerative colitis‑associated carcinogenesis: Studies in humans and animal models.Carcinogenesis,24,353-362.
  140. Shara, M,Ohia, SE,Schmidt, RE,Yasmin, T,Zardetto‑Smith, A,Kincaid, A(2004).Physico‑chemical properties of a novel (‑)‑hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days.Mol Cell Biochem,260,171-186.
  141. Shirakami, Y,Shimizu, M,Tsurumi, H,Hara, Y,Tanaka, T,Moriwaki, H(2008).EGCG and Polyphenon E attenuate inflammation‑related mouse colon carcinogenesis induced by AOM plus DDS.Mol Med Rep,1,355-361.
  142. Shishodia, S,Aggarwal, BB(2006).Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF‑kappa B‑regulated gene expression.Oncogene,25,1463-1473.
  143. Soler, C,Soriano, JM,Manes, J(2009).Apple‑products phytochemicals and processing: A review.Nat Prod Commun,4,659-670.
  144. Srivastava, R,Ahmed, H,Dixit, RK,Dharamveer,Saraf, SA(2010).Crocus sativus L.: A comprehensive review.Pharmacogn Rev,4,200-208.
  145. Stallmach, A,Hagel, S,Bruns, T(2010).Adverse effects of biologics used for treating IBD.Best Pract Res Clin Gastroenterol,24,167-182.
  146. Stavric, B(1994).Quercetin in our diet: From potent mutagen to probable anticarcinogen.Clin Biochem,27,245-248.
  147. Suskind, DL,Wahbeh, G,Burpee, T,Cohen, M,Christie, D,Weber, W(2013).Tolerability of curcumin in pediatric inflammatory bowel disease: A forced‑dose titration study.J Pediatr Gastroenterol Nutr,56,277-279.
  148. Takahama, U,Hirota, S(2013).Effects of starch on nitrous acid‑induced oxidation of kaempferol and inhibition of alpha‑amylase‑catalysed digestion of starch by kaempferol under conditions simulating the stomach and the intestine.Food Chem,141,313-319.
  149. Thorsteinsdottir, S,Gudjonsson, T,Nielsen, OH,Vainer, B,Seidelin, JB(2011).Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis.Nat Rev Gastroenterol Hepatol,8,395-404.
  150. Topcu‑Tarladacalisir, Y,Akpolat, M,Uz, YH,Kizilay, G,Sapmaz‑Metin, M,Cerkezkayabekir, A(2013).Effects of curcumin on apoptosis and oxidoinflammatory regulation in a rat model of acetic acid‑induced colitis: The roles of c‑Jun N‑terminal kinase and p38 mitogen‑activated protein kinase.J Med Food,16,296-305.
  151. Ukil, A,Maity, S,Karmakar, S,Datta, N,Vedasiromoni, JR,Das, PK(2003).Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid‑induced colitis.Br J Pharmacol,139,209-218.
  152. Ulbricht, C,Basch, E,Basch, S,Bent, S,Boon, H,Burke, D(2009).An evidence‑based systematic review of bilberry (Vaccinium myrtillus) by the Natural Standard Research Collaboration.J Diet Suppl,6,162-200.
  153. Ung, VY,Foshaug, RR,MacFarlane, SM,Churchill, TA,Doyle, JS,Sydora, BC(2010).Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti‑inflammatory effect in the IL‑10 gene‑deficient mouse model of IBD.Dig Dis Sci,55,1272-1277.
  154. Uno, JK,Kolek, OI,Hines, ER,Xu, H,Timmermann, BN,Kiela, PR(2006).The role of tumor necrosis factor alpha in down‑regulation of osteoblast Phex gene expression in experimental murine colitis.Gastroenterology,131,497-509.
  155. Varilek, GW,Yang, F,Lee, EY,deVilliers, WJ,Zhong, J,Oz, HS(2001).Green tea polyphenol extract attenuates inflammation in interleukin‑2‑deficient mice, a model of autoimmunity.J Nutr,131,2034-2039.
  156. Venkataranganna, MV,Rafiq, M,Gopumadhavan, S,Peer, G,Babu, UV,Mitra, SK(2007).NCB‑02 (standardized Curcumin preparation) protects dinitrochlorobenzene‑ induced colitis through down‑regulation of NFkappa‑B and iNOS.World J Gastroenterol,13,1103-1107.
  157. Viennois, E,Chen, F,Merlin, D(2013).NF‑kappaB pathway in colitis‑associated cancers.Transl Gastrointest Cancer,2,21-29.
  158. Wang, J,Yang, Z,Lin, L,Zhao, Z,Liu, Z,Liu, X(2012).Protective effect of naringenin against lead‑induced oxidative stress in rats.Biol Trace Elem Res,146,354-359.
  159. Wang, LS,Kuo, CT,Cho, SJ,Seguin, C,Siddiqui, J,Stoner, K(2013).Black raspberry‑derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.Nutr Cancer,65,118-125.
  160. Wang, YH,Ge, B,Yang, XL,Zhai, J,Yang, LN,Wang, XX(2011).Proanthocyanidins from grape seeds modulates the nuclear factor‑kappa B signal transduction pathways in rats with TNBS‑induced recurrent ulcerative colitis.Int Immunopharmacol,11,1620-1627.
  161. Wang, YH,Yang, XL,Wang, L,Cui, MX,Cai, YQ,Li, XL(2010).Effects of proanthocyanidins from grape seed on treatment of recurrent ulcerative colitis in rats.Can J Physiol Pharmacol,88,888-898.
  162. Waterman, E,Lockwood, B(2007).Active components and clinical applications of olive oil.Altern Med Rev,12,331-342.
  163. Wu, B,Cui, J,Zhang, C,Li, Z(2012).A polysaccharide from Agaricus blazei inhibits proliferation and promotes apoptosis of osteosarcoma cells.Int J Biol Macromol,50,1116-1120.
  164. Yadav, VR,Suresh, S,Devi, K,Yadav, S(2009).Novel formulation of solid lipid microparticles of curcumin for anti‑angiogenic and anti‑inflammatory activity for optimization of therapy of inflammatory bowel disease.J Pharm Pharmacol,61,311-321.
  165. Yadav, VR,Suresh, S,Devi, K,Yadav, S(2009).Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti‑inflammatory activity in rat colitis model.AAPS PharmSciTech,10,752-762.
  166. Yang, M,Wu, Y,Li, J,Zhou, H,Wang, X(2013).Binding of Curcumin with Bovine Serum Albumin in the Presence of iota‑Carrageenan and Implications on the Stability and Antioxidant Activity of Curcumin.J Agric Food Chem
  167. Yao, J,Wang, JY,Liu, L,Li, YX,Xun, AY,Zeng, WS(2010).Anti‑oxidant effects of resveratrol on mice with DSS‑induced ulcerative colitis.Arch Med Res,41,288-294.
  168. Zhang, M,Deng, CS,Zheng, JJ,Xia, J(2006).Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid‑induced chronic colitis.Acta Pharmacol Sin,27,1071-1077.
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