Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities

10.1016/j.jtcme.2014.11.008

Rafie Hamidpour；Mohsen Hamidpour；Soheila Hamidpour；Mina Shahlari

Alzheimer's disease ； angiogenesis inhibitor ； cancer ； cinnamon ； chronic diseases ； diabetes

Journal of Traditional and Complementary Medicine

5卷2期（2015 / 04 / 01）

66 - 70

英文

The purpose of this article is to use search engines such as PubMed and Scifinder to locate scholarly articles and reports pertaining to Cinnamon (肉桂ròu guì), its novel effects, preparation, analysis, and use in the prevention and treatment of serious illnesses, such as diabetes, cardiovascular diseases, Alzheimer's disease, and cancer. Cinnamon has been used traditionally in food preparations and as an herbal medicine to treat a variety of ailments and their symptoms. Cinnamon is known to have antioxidant, antibacterial, anti-inflammatory, and other therapeutic properties. New studies reaffirm the importance of cinnamon as a spice but also suggest that it may be a natural remedy to treat serious diseases such as type 2 diabetes, chronic digestion problems, cardiovascular diseases, and even cancer and Alzheimer's disease. This article presents a comprehensive analysis of the botanical, chemical, and pharmacological aspects of cinnamon.

1. Ahmed, MA(2012).Efficacy of ginger and cinnamon pharmaceutical preparations in patients with Helicobacter pylori-associated functional dyspepsia.Prime J Microbiol Res.,2,67-72.
2. Anderson, RA,Broadhurst, C,Polansky, MM(2004).Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin- like biological activity.J Agric Food Chem,52,65-70.
3. Baker, WL,Gutierrez-Williams, G,White, CM,Kluger, J,Coleman, C(2008).Effect of cinnamon on glucose control and lipid parameters.Diabetes Care,31,41-43.
4. Behrad, S,Yusof, MY,Goh, KL,Baba, AS(2009).Manipulation of probiotics fermentation of yogurt by cinnamon and licorice: effects on yogurt formation and inhibition of Helicobacter pylori growth in vitro.World Acad Sci Eng Technol,60,590-594.
5. Dugoua, J,Seely, D,Perri, D(2007).From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark.Can J Physiol Pharmacol,85,837-847.
6. Elahi, RK(2012).The effect of the cinnamon on dog's heart performance by focus on Korotkoff sounds.J Anim Vet Adv.,11,3604-3608.
7. Elshafie, MM,Nawar, IA,Algamal, MA,Mohammad, AS(2012).Evaluation of the biological effects for adding cinnamon volatile oil and TBHQ as antioxidant on rats’lipid profiles.Asian J Plant Sci,11,100-108.
8. Frydman-Marom, A,Levin, A,Farfara, D(2011).orally administrated cinnamon extract reduces b-Amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models.PLoS One.,28,e16564.
9. Hong, JW,Yang, GE,Kim, YB,Eom, SH,Lew, JH,Kang, H(2012).Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models.BMC Complement Altern Med,12,237.
10. Jindarat, S,Muangnoi, C,Changsiriporn, D(2006).Efficacy and safety of cinnamon stomachic mixture for patients with functional dyspepsia.Siriraj Med J.,58,1103-1106.
11. Kong, JO,Lee, SM,Moon, YS,Ahn, YJ(2007).Nematicidal activity of cassia and cinnamon oil compounds and related compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae).J Nematol,39,31-36.
12. Koppikar, SJ,Choudhari, AS,Suryavanshi, SA,Kumari, S,Chattopadhyay, S,Kaul-Ghanekar, R(2010).Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum Cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential.BMC Cancer,10,210.
13. Kwon, H,Jeon, WK,Hwang, J(2009).Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effecter function of CD8þ T cells.Cancer Lett,278,174-182.
14. Lu, J,Zhang, K,Nam, S,Anderson, RA,Jove, R,Wen, W(2010).Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling.Carcinogenesis,31,481-488.
15. Molania, T,Moghadamnia, A,Aghel, S(2012).The effect of cinnamaldehyde on mucositis and salivary antioxidant capacity in gamma-irradiated rats (a preliminary study).J Pharm Sci.,20,89.
16. Nuryastuti, T,Van Der Mei, HC,Busscher, HJ,Iravati, S,Aman, AT,Korm, BP(2009).Effect of cinnamon oil on IcaA expression and biofilm formation by Staphylococcus epidermidis.Appl Environ Microbiol,75,6850-6855.
17. Oh, MJ(2011).The acaricidal and repellent effect of cinnamon essential oil against house dust mite.World Acad Sci Eng Technol,60,710-714.
18. Peterson, DW,George, RC,Scaramozzino, F(2009).Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro.J Alzheimers Dis,17,585-597.
19. Prabuseenivasan, S,Jayakumar, M,Ignacimuthu, S(2006).In vitro antibacterial activity of some plant essential oils.BMC Complement Altern Med,6,39.
20. Ranasinghe, P,Perera, S,Gunatilake, M(2012).Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model.Pharmacognosy Res,4,73-79.
21. Roussel, A,Hininger, I,Benaraba, R,Ziegenfuss, TN,Anderson, RA(2009).Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese.J Am Coll Nutr,28,16-21.
22. Safdar, M,Khan, A,Ali Khan Khattak, MM,Siddique, M(2004).Effect of various doses of cinnamon on blood glucose in diabetic individuals.Pak J Nutr.,3,268-272.
23. Shan, B,Cai, YZ,Brooks, DJ,Corke, H(2007).Antibacterial properties and major bioactive component of cinnamon stick (Cinnamomum burmannii): activity against food has borne pathogenic bacteria.J Agric Food Chem,55,5484-5490.
24. Vinitha, M,Ballal, M(2008).In vitro anticandidal activity of Cinnamomum verum.J Med Sci.,8,425-428.
25. Wang, S,Chen, P,Chang, S(2005).Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophloeum) leaves against wood decay fungi.Bioresour Technol,96,813-818.
26. Ziegenfuss, TN,Hofheins, JE,Mendel, RW,Landis, J,Anderson, RA(2006).Effect of a water- soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women.J Int Soc Sports Nutr,3,45-53.

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