Clinical efficacy and tolerability of two Japanese traditional herbal medicines, Hachimi-jio-gan and Gosha-jinki-gan, for lower urinary tract symptoms with cold sensitivity

10.1016/j.jtcme.2015.03.010

Hiroshi Yagi；Ryo Sato；Kojiro Nishio；Gaku Arai；Shigehiro Soh；Hiroshi Okada

Hachimi-jio-gan ； Gosha-jinki-gan ； Cold sensitivity ； Oxidative stress ； Lower urinary tract symptoms

Journal of Traditional and Complementary Medicine

5卷4期（2015 / 10 / 01）

258 - 261

英文

We evaluated the efficacy and tolerability of Hachimi-jio-gan (HJG; 八味地黃丸bā wèi dì huáng wán) and Gosha-jinki-gan (GJG; 濟生腎氣丸jì shēng shèn qì wán), two traditional Japanese medicines, in 60 patients with lower urinary tract symptoms (LUTS) having cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. All patients received a mixture of HJG or GJG for 12 weeks in addition to α1-blockers or antimuscarinic drugs as add-on therapy. International Prostate Symptom Score, International Prostate Symptom Score-Quality of Life, Benign Prostatic Hyperplasia Impact Index, and the number of nocturnal voids were statistically much improved. However, there was no change in maximal urinary flow rate and post-void residual urine. Urinary 8-hydroxy-2-deoxyguanosine was statistically greatly improved from baseline after treatment in the HJG group compared to the GJG group. Adverse reactions were observed in 8.3% of patients, but all reactions were mild. Both HJG and GJG mixtures can serve as safe and effective potential therapeutic alternatives in patients with LUTS and cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. Additionally, HJG mixture was found to have anti-oxidative activity, and therefore further long-term clinical investigations are needed to examine its anti-aging effects in addition to its effect on urinary symptoms.

1. Abrams, P,Freeman, R,Anderstrom, C,Mattiasson, A(2003).The standardization of terminology in lowerurinary tract function: report from the standardization subcommittee of the International Continence Society.Urology,61,37-49.
2. Aikaw, K,Leggett, RE,Levin, RM(2003).Effect of age on hydrogen peroxide mediated contraction damage in the male bladder.J Urol,170,2082-2085.
3. Gotoh, A,Goto, K,Sengoku, A(2004).Inhibition mechanism of Gosha-ginki-gan on the micturition reflex in rats.Pharmacol Sci.,96,115-123.
4. Huang, YB,Lin, MW,Chao, Y,Haung, CT,Tsai, YH,Wu, PC(2014).Anti-oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol.Int J Urol,21,94-98.
5. Imamura, T,Ishizuka, O,Aizawa, N(2008).Gosha-ginki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder.Neurourol Urodyn,27,832-837.
6. Imamura, T,Ishizuka, O,Nishizawa, O(2013).Cold stress induces lower urinary tract symptoms.Int J Urol,20,661-669.
7. Imamura, T,Ishizuka, O,Nishizawa, O(2008).Cold environmental stress induces detrusor overactivity via resiniferatoxin-sensitive nerves in conscious rats.Neurourl Urodyn,27,348-352.
8. Inoue, H,Ishizuka, O,Imamura, T(2012).Relationship between toe temperature and lower urinary tract symptoms.LUTS.,4,144-149.
9. Ishikawa, S,Kubo, T,Sunagawa, M,Tawaratsumita, Y.,Sato, T(2011).Influence of Chinese herbal medicine on reactive oxygen and blood fluidity in rats.Kampo Med,3,337-346.
10. Kupelian, V,Rosen, RC,Link, CL(2009).Association of urological symptoms and chronic illness in men and women : contributions of symptom severity and duration - results from the BACH Survey.J Urol,181,694-699.
11. Masuda, H,Kihara, K,Saito, K(2008).Reactive oxygen species mediate detrusor over-activity via sensitization of afferent pathway in the bladder of anaesthetized rats.BJU Int.,101,775-780.
12. Nishijima, S,Sugaya, K,Miyazato, M(2007).Effects of gosha-ginki-gan, a blended herbal medicine, on bladder activity in rats.J Urol,177,762-765.
13. Ogushi, T,Takahashi, S(2007).Effect of Chinese herbal medicine on overactive bladder.Acta Urol Jpn.,53,857-862.
14. Suzuki, T,Higashi, H,Saitoh, K(1997).Effects of gosha-ginki-gan on urinary bladder contraction in dogs.Hinyokika Kiyo,43,271-274.
15. Suzuki, T,Kurokawa, K,Suzuki, K(1996).Effect of gosha-ginki-gan anesthetized dogs.Hinyokika Kiyo,42,951-955.
16. Tokunaga, S,Nakashima, T,Yamaguchi, K(1992).Clinical evaluation of Goshajinkigan in patients with urinary disturbance.Nishinihon J Urol.,54,1067-1070.
17. Yagi, H,Nishio, K,Sato, R(2013).Effect of Hachimijiogan and its additional prescription for anticholinergic agent-resistant overactive bladder.Kampo Med,2,99-103.
18. Yamada, K,Suzuki, E,Nakaki, T(2005).Aconiti tuber increases plasma nitrite and nitrate levels in humans.J Ethnopharmacol,96,165-169.

1. (2024).Chinese herbal medicine may reduce major adverse cardiovascular events in patients with dialysis hypotension: A taiwan nationwide cohort study.Journal of Traditional and Complementary Medicine,14(5),550-557.