Comparison of efficacy of alternative medicine with allopathy in treatment of oral fungal infection

10.1016/j.jtcme.2014.11.023

Sahil Maghu；Vela D. Desai；Rajeev Sharma

candidiasis ； clotrimazole ； conservative management ； fungal infection ； tea tree oil

Journal of Traditional and Complementary Medicine

6卷1期（2016 / 01 / 01）

38 - 41

英文

This clinical study assessed and compared the efficacy of tea tree oil (TTO), an alternative form of medicine, with clotrimazole (i.e., allopathy) and a conservative form of management in the treatment of oral fungal infection. In this interventional, observational, and comparative study, we enrolled 36 medically fit individuals of both sexes who were aged 20-60 years old. The participants were randomly assigned to three groups. Group I was given TTO (0.25% rinse) as medicament, Group II was given clotrimazole, and Group III was managed with conservative treatment. The results were analyzed from the clinical evaluation of lesions, changes in four most common clinical parameters of lesions, and subjective symptoms on periodic follow-up. Based on the results, the percentage efficiency of the two groups were taken and compared through a bar graph on the scale of 1. No toxicity to TTO was reported. Group I (TTO) was found to be more efficient than the other two groups, as changes in four parameter indices of lesions were noted, and results for all three groups were compared on a percentage basis. The study concluded that TTO, being a natural product, is a better nontoxic modality compared to clotrimazole, in the treatment of oral fungal infection and has a promising future for its potential application in oral health products.

1. Baginski, M,Czub, J(2009).Amphotericin B and its new derivatives e Mode of action.Current Drug Metabolism,10(5),459-469.
2. Barr, A,Chapman, J,Smith, N,Beveridge, M.(1988).Traditional Bush Medicines - An Aboriginal pharmacopoeia.Victoria:Greenhouse Publications.
3. Carson, CF,Hammer, KA,Riley, TV(2006).Melaleuca alternifolia (tea tree oil): A review of antimicrobial and other medicinal properties.Clin Microbiol Rev.,19(1),50-62.
4. Cox, SD,Mann, CM,Markham, JL(2000).The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil).J Appl Microbiol,88,170-175.
5. Ellepola, ANB,Samaranayake, LP(2000).Oral candidal infections and antimycotics.Crit Rev Oral Biol Med,11,172-198.
6. Finlay-Jones, J(2002).Antiinflammatory. Activity of Tea Tree Oil.Rural Industries Research & Development Corporation Publication.
7. Furneri, PM,D’Arrigo, M,Ginestra, G,Giuseppina, M,Bisignano, M(2010).Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia against S. aureus and E. coli.Phytomedicine,17,317-322.
8. Greay, SJ,Hammer, KA(2011).Recent developments in bioactivity of mono and diterpenes anti-cancer and anti-microbial activity.Phytochemistry Reviews,14(1)
9. Hammer, KA,Carson, CF,Riley, TV(2004).Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae.J Antimicrob Chemother,53,1081-1085.
10. Hammer, KA,Carson, CF,Riley, TV(2002).In vitro activity of Melaleuca alternifolia oil against dermatophytes and other filamentous fungi.J Antimicrob Chemother,53,1081-1085.
11. Hart, PH,Brand, C,Carson, CF,Riley, TV,Prager, RH,Finlay-Jones, JJ(2000).Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes.Inflamm Res.,49,619-626.
12. Jandourek, A,Vaishampayan, JK,Vazquez, JA(1998).Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients.AIDS,12,1033-1037.
13. Juergens, UR,Stober, M,Schmidt-Schilling, L,Kleuver, T,Vetter, H(1998).Anti-inflammatory effects of eucalyptol (1.8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivo.Eur J Med Res,3,407-412.
14. Juergens, UR,Stober, M,Vetter, H(1998).Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineole) in human blood monocytes in vitro.Eur J Med Res,3,508-510.
15. Renstrup, G(1970).Occurrence of Candida in oral leukoplakias.Acta Pathol Microbiol Scand B Microbiol Immunol,78,421-424.
16. Santos, FA,Rao, VS(2000).Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils.Phytother Res,14,240-244.
17. Vazquez, JA,Zawawi, AA(2002).Efficacy of alcohol-based and alcohol-free melaleuca oral solution for the treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS.HIV Clin Trials,3,379-385.
18. Veien, NK,Rosner, K,Skovgaard, G(2004).Is tea tree oil an important contact allergen?.Contact Dermatitis,50,378-379.