Quality standards for Hutabhugādi cūrṇa (Ayurvedic Formulary of India)

10.1016/j.jtcme.2014.11.019

Pushpendra；Koppala Narayana Sunil Kumar；Priyadarshini；Bantwal Shivarama Holla；Basaviah Ravishankar；Betkeri Yashovarma

adulteration and substitution ； Ayurvedic Formulary of India ； monograph ； polyherbal medicines ； quality standards ； standardization

Journal of Traditional and Complementary Medicine

6卷1期（2016 / 01 / 01）

54 - 64

英文

In India, herbal medicines are mainly based on the Ayurvedic system. The main drawback of traditional medicines is a lack of standardized products. Standardization of any herbal formulation is essential in order to assess the quality, purity, safety, and efficacy of drugs based on the analysis of their active properties. Testing of Ayurvedic preparations using scientific methodologies will add to quality and authenticity of the product. This article reports standardization parameters for Hutabhugādi cūrṇa (HC) used traditionally in the treatment of Agnimāndya (digestive impairment), Pāndu (anemia), Sopha (edema), and Ārsa (piles). The formulation was prepared as per Ayurvedic Formulary of India, and it was standardized by organoleptic characterization, macro-microscopic evaluation, physicochemical testing, and thin-layer chromatography/high-performance thin-layer chromatography profiling employing a standard methodology. Results of the experiments conducted provided diagnostic characteristics to identify and standardize the formulation prepared using official ingredients of HC. Based on the data obtained, a monograph on quality standards for HC is proposed. The monograph based on the present investigation results would serve as a document to control the quality of HC.

1. Department of AYUSH, Ministry of Health and Family Welfare, Government of India(2007).The Ayurvedic Pharmacopoeia of India.New Delhi:Department of AYUSH, Ministry of Health and Family Welfare, Government of India.
2. Department of AYUSH,Ministry of Health and Family Welfare, Government of India(2008).The Ayurvedic Pharmacopoeia of India.New Delhi:Department of AYUSH, Ministry of Health and Family Welfare, Government of India.
3. Department of Indian Systems of Medicine and Homoeopathy, Ministry of Health and Family Welfare, Government of India(2003).Ayurvedic Formulary of India.New Delhi:Department of Indian Systems of Medicine and Homoeopathy, Ministry of Health and Family Welfare, Government of India.
4. EMEA(2005).EMEA. Guidelines on Quality of Herbal Medicinal Products/Traditional Medicinal Products. EMEA/CVMP/814OO Review. London: European Agency for the Evaluation of Medicinal Products (EMEA); 2005..
5. John, A,Gayathri Devi, V,Gopakumar, K(2011).Physico-chemical evaluation of Hutabhugadi churna-an Ayurvedic formulation.J Res Educ Indian Med,XVII,7-13.
6. Kunle, OF,Egharevba, HO,Ahmadu, PO(2012).Standardization of herbal medicines-a review.Int J Biodivers Conserv.,4,101-112.
7. Pushpendra, Sunil Kumar KN,Priyadarshini, Holla BS,Ravishankar, B,Yashovarma, B(2014).Simple modus operandi to bring down microbial load of herbal drugs to pharmacopoeial limit-a study on ingredients of Hutabhugadi curna.J Sci Innov Res,2,1040-1043.
8. Sethi, PD(1996).High Performance Thin Layer Chromatography.New Delhi:CBS Publishers.
9. Stahl, I.(1969).Thin Layer Chromatography: A Laboratory Hand Book.Berlin:Springer-Verlag.
10. Wagner, H,Bladt, S.(1996).Plant Drug Analysis.Hiedelberg:Springer-Verlag.
11. WHO(2000).General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine.Geneva:World Health Organization.
12. WHO(2002).General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine.Geneva:World Health Organization.
13. WHO(2005).Global Atlas of Traditional, Complementary and Alternative Medicine.Geneva:World Health Organization.
14. WHO(2005).Global Atlas of Traditional, Complementary and Alternative Medicine.Geneva:World Health Organization.

1. Thekkekara Devassy Babu,Sasidharan Salini,Nanu Sasidharan,Nair Meera,Jose Padikkala,Adangam Purath Shahid,Achuthan Chathrattil Raghavamenon(2018).Kingiodendron pinnatum, a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta.Journal of Traditional and Complementary Medicine,8(1),244-250.