Curcumin: An age-old anti-inflammatory and anti-neoplastic agent

10.1016/j.jtcme.2016.08.002

Matthew C. Fadus；Cecilia Lau；Jai Bikhchandani；Henry T. Lynch

Curcumin ； Chemoprophylaxis ； Turmeric ； Anti-inflammatory ； Curry ； Cancer

Journal of Traditional and Complementary Medicine

7卷3期（2017 / 07 / 01）

339 - 346

英文

Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. Several experimental and pharmacologic trials have demonstrated its efficacy in the role as an anti-inflammatory agent. Curcumin has been shown to be effective in treating chronic conditions like rheumatoid arthritis, inflammatory bowel disease, Alzheimer's and common malignancies like colon, stomach, lung, breast, and skin cancers. As treatments in medicine become more and more complex, the answer may be something simpler. This is a review article written with the objective to systematically analyze the wealth of information regarding the medical use of curcumin, the ＂curry spice＂, and to understand the existent gaps which have prevented its widespread application in the medical community.

1. Abdul Khalek, FJ,Gallicano, GI,Mishra, L(2010).Colon cancer stem cells.Gastrointest Cancer Res,S16-S23.
2. Aggarwal, BB,Surh, YJ,Shishodia, S(2007).The molecular targets and therapeutic uses of curcumin in health and disease.Adv Exp Med Biol.,595.
3. Aggarwal, BB,Takada, Y,Oommen, OV(2004).From chemoprevention to chemo-therapy: common targets and common goals.Expert Opin Investig Drugs,13,1327-1338.
4. Aoki, H,Takada, Y,Kondo, S,Sawaya, R,Aggarwal, BB,Kondo, Y(2007).Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and ERK signaling pathways.Mol Pharmacol,72(1),29-39.
5. Bayet-Robert, M,Morvan, D(2013).Metabolomics reveals metabolic targets and biphasic responses in breast cancer cells treated by curcumin alone and in association with docetaxel.PLoS One,8(3)
6. Boman, BM,Huang, E(2008).Human colon cancer stem cells: a new paradigm in gastrointestinal oncology.J Clin Oncol.,26,2828-2838.
7. Boral, D,Nie, D(2012).Cancer stem cells and niche mircoenvironments.Front Biosci (Elite Ed),4,2502-2514.
8. Buhrmann, C,Kraehe, P,Lueders, C,Shayan, P,Goel, A,Shakibaei, M(2014).Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT.PLoS One,9(9),e107514.
9. Burgos-Moron, E,Calderon-Montano, JM,Salvador, J,Robles, A,Lopez-Lazaro, M(2010).The dark side of curcumin.Int J Cancer,126(7),1771-1775.
10. Caesar, I,Jonson, M,Nilsson, K,Thor, S,Hammarström, P(2012).Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.PLoS One,7(2)
11. Carroll, RE,Benya, RV,Turgeon, DK(2011).Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia.Cancer Prev Res,4,354-364.
12. Chandran, B,Goel, A(2012).A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.Phytother Res Phytother Res,26(11),1719-1725.
13. Cheng, AL,Hsu, CH,Lin, JK(2001).Phase I clinical trial of curcumin, a chemo-preventive agent, in patients with high-risk or pre-malignant lesions.Anti-cancer Res,21,2895-2900.
14. Dick, JE(2008).Stem cell concepts renew cancer research.Blood,112(13),4793-4807.
15. Eigner, D,Scholz, D(1999).Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal.J Ethnopharmacol,67,1-6.
16. Epelbaum, R,Schaffer, M,Vizel, B,Badmaev, V,Bar-Sela, G.(2010).Curcumin and gemcitabine in patients with advanced pancreatic cancer.Nutr Cancer,62,1137-1141.
17. Gaedeke, J,Noble, NA,Border, WA(2005).Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1.Kidney Int,68,2042-2049.
18. Garcea, G,Jones, DJ,Singh, R(2004).Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration.Br J Cancer,90,1011-1015.
19. Gerrits, J,Wetering, J,Weimar, W,Besouw, N(2010).T-Cell reactivity during tapering of immunosuppression to low-dose monotherapy prednisolone in HLA-identical living-related renal transplant recipients.Transplantation,8(2),907-914.
20. Goel, A,Kunnumakkara, AB,Aggarwal, BB(2007).Curcumin as "Curecumin": from kitchen to clinic.Biochem Pharmacol
21. Gout, S,Huot, J(2008).Role of cancer microenvironment in metastasis: focus on colon cancer.Cancer Microenviron,1,69-83.
22. Gupta, S,Patchva, S,Aggarwal, B(2013).Therapeutic roles of curcumin: lessons learned from clinical trials.APPS J,15(1)
23. Gupta, Subash C,Patchva, Sridevi,Aggarwal, Bharat B(2012).Therapeutic roles of curcumin: lessons learned from clinical trials.AAPS J,15(1),195-218.
24. Hata, M,Sasaki, E,Ota, M,Fujimoto, K,Yajima, J,Shichida, T(1997).Allergic contact dermatitis from curcumin 1827 (turmeric).Contact Dermat,36,107-108.
25. Huang, M,Lysz, T,Ferraro, T,Abidi, T,Laskin, J,Conney, A(1991).Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activity.Cacner Res,51,813-819.
26. Ireson, C,Orr, S,Jones, DJ(2001).Characterization of metabolites of the chemo-preventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbolester-induced prostaglandin E2 production.Cancer Res.,61,1058-1064.
27. Ireson, CR,Jones, DJ,Orr, S(2002).Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.Cancer Epidemiol Biomarkers Prev,11,105-111.
28. Irving, GR,Howells, LM,Sale, S(2013).Prolonged biologically active colonic tissue levels of curcumin achieved after oral administrationda clinical pilot study including assessment of patient acceptability.Cancer Prev Res,6,119-128.
29. Irving, GR,Karmokar, A,Berry, DP,Brown, K,Steward, WP(2011).Curcumin: the potential for efficacy in gastrointestinal diseases.Best Pract Res Clin Gastroenterol,25,519-534.
30. Jemal, A,Siegel, R,Ward, E(2008).Cancer statistics, 2008.CA Cancer J Clin,58(2),71-96.
31. Jiao, Y,Wilkinson, J,Di, X(2009).Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator.Blood,113,462-469.
32. Kanai, M,Imaizumi, A,Otsuka, Y(2012).Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.Cancer Chemother Pharmacol,69,65-70.
33. Kanai, M,Otsuka, Y,Otsuka, K(2013).A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.Cancer Chemother Pharmacol,71,1521-1530.
34. Kang, Q,Chen, A(2009).Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells.Br J Pharmacol,157(8),1354-1367.
35. Kumar, S,Ahuja, V,Vishnubhatla, S,Prasad, K,Kumar, A(1996).Curcumin for maintenance of remission in ulcerative colitis.Protoc Cochrane Database Syst Rev,10.
36. Lengyel, E,Sawada, K,Salgia, R(2007).Tyrosine kinase mutations in human cancer.Curr Mol Med.,7,77-84.
37. Li, L,Ahmed, B,Mehta, K,Kurzrock, R(2007).Liposomal curcumin 1570 with and without oxaliplatin: effects on cell growth, 1571 apoptosis, and angiogenesis in colorectal cancer.Mol Cancer Ther,6,1276-1282.
38. Li, M,Zhang, Z,Hill, DL,Wang, H,Zhang, R(2007).Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway.Cancer Res,67,1988-1996.
39. Liontas, A,Yeger, H(2004).Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma.Anticancer Res,24,987-998.
40. Lopez-Lazaro, M.(2008).Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.Mol Nutr Food Res.,52(suppl 1),S103-S127.
41. Mathew, A,Fukuda, T,Nagaoka, Y(2012).Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease.PLoS One,7(3)
42. Mcnally, Stephen,Harrison, Ewen,Ross, James,Garden, O,Wigmore, Stephen(2007).Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, P38 activation and phosphatase inhibition.Int J Mol Med,19(1)
43. Midura-Kiela, M,Radhakrishnan, V,Larmonier, C,Laubitz, D,Ghishan, F,Kiela, P(2011).Curcumin inhibits interferon- signaling in colonic epithelial cells.AJP Gastrointest Liver Physiol,302(1),G85-G96.
44. Naz, RK,Lough, ML(2014).Curcumin as a potential non-steroidal contraceptive with spermicidal and microbicidal properties.Eur J Obstet Gynecol Reprod Biol,176,142-148.
45. Pan, MH,Huang, TM,Lin, JK(1999).Biotransformation of curcumin through reduction and glucuronidation in mice.Drug Metab Dispos,27,486-494.
46. Pin, AL,Houle, F,Huot, J(2011).Recent advances in colorectal cancer research: the microenvironment impact.Cancer Microenviron,4,127-131.
47. Polasa, K,Raghuram, TC,Krishna, TP,Krishnaswamy, K(1992).Effect of turmeric on urinary mutagens in smokers.Mutagenesis,7(2),107-109.
48. Purusotam, Basnet,Natasa, Skalko-Basnet(2011).Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment.Molecules,4567-4598.
49. Ravindranath, V,Chandrasekhara, N(1982).Metabolism of curcumin-studies with [3H]curcumin.Toxicology,22(4),337-344.
50. Schiavoni, G,Gabriele, L,Mattei, F(2013).The tumor microenvironment: a pitch for multiple players.Front Oncol,3
51. Sharma, RA,Euden, SA,Platton, SL(2004).Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.Clin Cancer Res,10,6847-6854.
52. Shim, JS,Kim, JH,Cho, HY(2003).Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.Chem Biol.,10,695-704.
53. Shishodia, S,Singh, T,Chaturvedi, MM(2007).Modulation of transcription factors by curcumin.Adv Exp Med Biol,595,127-148.
54. Shoba, G,Joy, D,Joseph, T,Majeed, M,Rajendran, R,Srinivas, PS(1998).Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.Planta Med,64,353-356.
55. Skrzypczak-Jankun, E,Zhou, K,McCabe, NP,Selman, SH,Jankun, J(2003).Structure of curcumin in complex with lipoxygenase and its significance in cancer.Int J Mol Med.,12,17-24.
56. Song, G,Mao, YB,Cai, QF,Yao, LM,Ouyang, GL,Bao, SD(2005).Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosisrelated protein expression.Braz J Med Biol Res,38,1791-1798.
57. Syng-Ai, C,Kumari, AL,Khar, A(2004).Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2.Mol Cancer Ther,3,1101-1108.
58. Tikhomirov, O,Carpenter, G(2003).Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation.Cancer Res,63,39-43.
59. Todaro, M,Francipane, MG,Medema, JP,Stassi, G(2010).Colon cancer stem cells: promise of targeted therapy.Gastroenterology,138,2151-2162.
60. Wang, JC,Dick, JE(2005).Cancer stem cells: lessons from leukemia.Trends Cell Biol,15(9),494-501.
61. Wang, Ke,Fan, Hua,Chen, Qingsen(2015).Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.Anti-Cancer Drugs,26(1),15-24.
62. Yang, F,Lim, GP,Begum, AN(2005).Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.J Biol Chem,280,5892-5901.
63. Yu, Y,Kanwar, SS,Patel, BB,Nautiyal, J,Sarkar, FH,Majumdar, AP(2009).Elimination of colon cancer stem-like cells by the combination of curcumin and FOLFOX.Transl Oncol,2(4),321-328.
64. Zhou, D,Ding, N,Du, Z(2014).Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation.Mol Med Rep Mol Med Rep,10(3),1315-1322.

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