题名

Biological activities and medicinal properties of Asafoetida: A review

DOI

10.1016/j.jtcme.2016.11.004

作者

Augustine Amalraj;Sreeraj Gopi

关键词

Ferula asafoetida Linn. ; Oleo-gum-resin ; Sulfur compounds ; Sesquiterpenes ; Biological activities

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

7卷3期(2017 / 07 / 01)

页次

347 - 359

内容语文

英文

中文摘要

Ferula asafoetida Linn. is a main source of asafoetida, a strong, tenacious and sulfurous odor, and oleo-gum resin of medicinal and nutritional importance. Asafoetida has been consumed as a spice and a folk medicine for centuries. Recent studies have shown several promising activities particularly relaxant, neuroprotective, memory enhancing, digestive enzyme, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, anticarcinogenic, anticancer, anticytotoxicity, antiobesity, anthelmintic and antagonistic effect. This review effectively deals with phytochemistry and various pharmacological and clinical studies of asafoetida.

主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Abd El-Razek, MH(2007).A new ester isolated from Ferula asafoetida L.Biosci Biotechnol Biochem,71,2300-2303.
  2. Abd El-Razek, MH,Ohta, S,Ahmed, AA,Hirata, T(2001).Sesquiterpene coumarins from the roots of Ferula asafoetida.Phytochemistry,58,1289-1295.
  3. Abu-Zaiton, AS(2010).Anti-diabetic activity of Ferula asafoetida extract in normal and alloxan-induced diabetic rats.Pak J Biol Sci.,13,97-100.
  4. Akhlaghi, F,Rajaei, Z,Hadjzadeh, M,Iranshahi, M,Alizadeh, M(2012).Antihyperglycemic effect of asafoetida (Ferula asafoetida oleo-gum-resin) in streptozotocin-induced diabetic rats.World Appl Sci J,17,157-162.
  5. Al-Jafari, AH,Vila, R,Freixa, B,Costa, J,Canigueral, S(2012).Antifungal compounds from the rhizome and roots of F. hermonis.Phytother Res
  6. Alqasoumi, S.(2012).Anxiolytic effect of Ferula asafoetida L. in rodents.J Pharmacogn Phytother,4,86-90.
  7. Angelini, P,Pagiotti, R,Venanzoni, R,Granetti, B(2009).Antifungal and allelopathic effects of asafoetida against Trichoderma harzianum and Pleurotus spp.Allelopath J.,23,357-368.
  8. Appendino, G,Maxia, L,Bascope, M(2006).A meroterpenoid NF-kB inhibitor and drimane sesquiterpenoids from asafetida.J Nat Prod,69,1101-1104.
  9. Appendino, G,Tagliapietra, S,Mario Nano, G,Jakupovic, J(1993).Sesquiterpene coumarin ethers from asafetida.Phytochemistry,35,183-186.
  10. Azizian, H,Rezvani, ME,Esmaeilidehaj, M,Bagheri, SM(2012).Anti-obesity, fat lowering and liver steatosis protective effects of Ferula asafoetida gum in Type 2 diabetic rats: possible involvement of leptin.Iran J Diabetes Obes,4,120-126.
  11. Bagheri, SM,Dashti-R, MH(2015).Influence of asafoetida on prevention and treatment of memory impairment induced by D-galactose and NaNO2 in mice.Am J Alzheimers Dis Other Demen,30,607-612.
  12. Bagheri, SM,Hejazian, SH,Dashti-R, MH(2014).The relaxant effect of seed's essential oil and oleo-gum-resin of Ferula asafoetida on isolated rat's ileum.Ann Med Health Sci Res.,4,238-241.
  13. Bagheri, SM,Sahebkar, A,Gohari, AR,Saeidnia, S,Malmir, M,Iranshahi, M(2010).Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species.Pharm Biol,48,242-246.
  14. Bagheri, SM,Yadegari, M,Porentezari, M(2015).Effect of Ferula asafoetida oleo gum resin on spermatic parameters and testicular histopathology in male Wistar rats.J Ayurveda Integr Med,6,175-180.
  15. Banerji, A,Mallick, B,Chatterjee, A,Budzikiewicz, H,Breuer, M(1988).Assafoetidin and ferocolicin, two sesquiterpenplatoid coumarins from Ferula asafoetida regel.Tetrahedron Lett,29,1557-1560.
  16. Bayrami, G,Boskabady, MH,Iranshahi, M,Gholamnezhad, Z(2013).Relaxant effects of asafoetida extract and its constituent umbelliprenin on guinea-pig tracheal smooth muscle.Chin J Integr Med,1-6.
  17. Bhatnager, R,Rani, R,Dang, AS(2015).Antibacterial activity of Ferula asafoetida: a comparison of red and white type.J Appl Biol Biotechnol,3,18-21.
  18. Buddrus, J,Bauer, H,Abu-Mustafa, E(1985).Foetidin, a sesquiterpenoid coumarin from Ferula asafoetida.Phytochemistry,24,869-870.
  19. Caglioti, L,Naef, H,Arigoni, D,Jeper, O(1959).Zur Kenntnis der Sesquiterpene und Azulene. 127. Mitteilung. Über die Inhaltsstoffe der Asa foetida II. Farnesiferol B und C.Helv Chim Acta,42,2557-2570.
  20. Caglioti, L,Naef, H,Arigoni, D,Jeper, O(1958).Zur Kenntnis der Sesquiterpene und Azulene. 126. Mitteilung. Über die Inhaltsstoffe der Asa foetida I. Farnesiferol A.Helv Chim Acta,41,2278-2292.
  21. Cha, M-R,Choi, YH,Choi, CW(2011).Galbanic acid, a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida, blocks protein farnesyltransferase.Planta Med,77,52-54.
  22. Christensen, LP,Brandt, K(2006).Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis.J Pharm Biomed Anal,41,683-693.
  23. Dandagi, PM,Patil, MB,Mastiholimath, VS,Gadad, AP,Dhumansure, RH(2008).Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants.Indian J Pharm Sci.,70,265-268.
  24. De, AK(ed.)(2011).Spices: The Elixir of Life.New Delhi, India:Original Publications.
  25. Dehpour, AA,Ebrahimzadeh, MA,Fazel, NS,Mohammad, NS(2009).Antioxidant activity of the methanol extract of Ferula asafoetida and its essential oil composition.Grasas Aceites,60,405-412.
  26. Divya, K,Ramalakshmi, K,Murthy, PS,Rao, LJM(2014).Volatile oils from Ferula asafoetida varieties and their antimicrobial activity.LWT Food Sci Technol.,59,774-779.
  27. Duan, H,Takaishi, Y,Tori, M(2002).Polysulfide derivatives from Ferula foetida.J Nat Prod.,65,1667-1669.
  28. El Deeb, HK,Al Khadrawy, FM,Abd El-Hameid, AK(2012).Inhibitory effect of Ferula asafoetida L. (Umbelliferae) on Blastocystis sp. subtype 3 growth in vitro.Parasitol Res.,111,1213-1221.
  29. Emami, A,Fasihi, S,Mehregan, I.(2010).Medicinal Plants.Tehran:Andisheh Avar.
  30. Fatehi, M,Farifteh, F,Fatehi-Hassanabad, Z(2004).Antispasmodic and hypotensive effects of Ferula asafoetida gum extract.J Ethnopharmacol,91,321-324.
  31. Gholamnezhad, Z,Byrami, G,Boskabady, MH,Iranshahi, M(2012).Possible mechanism(s) of the relaxant effect of asafoetida (Ferula asafoetida) oleo-gum-resin extract on guinea-pig tracheal smooth muscle.Avicenna J Phytomed,2,10-16.
  32. Gundamaraju, R.(2013).Evaluation of anti-helmintic activity of Ferula foetida "Hing- A natural Indian spice" aqueous extract.Asian Pac J Trop Dis.,3,189-191.
  33. Hofer, O,Widhalm, M,Greger, H(1994).Circular dichroism of sesquiterpene-umbelliferone ethers and structure elucidation of a new derivative isolated from the gum resin "Asa Foetida".Monatsh Chem,115,1207-1218.
  34. Iran Herbal Pharmacopeia Edition Committee(2002).Iran Herbal Pharmacopeia.Ministry of Health & Medical Education, Food and Medicine Deputy Office Publication.
  35. Iranshahi, M,Amin, G,Salehi Sourmaghi, M,Shafiee, A,Hadjiakhoondi, A(2006).Sulphur-containing compounds in the essential oil of the root of Ferula persica willd. var. persica.Flavour Frag J,21,260-261.
  36. Iranshahy, M,Iranshahi, M(2011).Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula asafoetida oleo-gum-resin) - a review.J Ethnopharmacol,134,1-10.
  37. Kajimoto, T,Yahiro, K,Nohara, T(1989).Sesquiterpenoid and disulphide derivatives from Ferula asafoetida.Phytochemistry,28,1761-1763.
  38. Kamble, VA,Patil, SD(2008).Spice-derived essential oils: effective antifungal and possible therapeutic agents.J Herbs Spices Med Plants,14,129-143.
  39. Kavoosi, G,Rowshan, V(2013).Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula asafoetida oleo-gum-resin: effect of collection time.Food Chem,138,2180-2187.
  40. Kelly, KJ,Nue, J,Camitta, BM,Honig, GR(1984).Methemoglobinemia in an infant treated with the folk remedy glycerited asafetida.Pediatrics,73,717-719.
  41. Khazdair, MR,Boskabady, MH(2015).The relaxant effect of Ferula asafoetida on smooth muscles and the possible mechanisms.J HerbMed Pharmacol,4,40-44.
  42. Kiyanmehr, M,Boskabady, MH,Khazdair, MR,Hashemzehi, M(2016).Possible mechanisms for functional antagonistic effect of Ferula asafoetida on muscarinic receptors in tracheal smooth muscle.Malays J Med Sci.,23,35-43.
  43. Korashy, HM,Al-Jenoobi, FI,Raish, M(2015).Impact of herbal medicines like Nigella sativa, Trigonella foenum-graecum, and Ferula asafoetida, on cytochrome P450 2C11 gene expression in rat liver.Drug Res,65,366-372.
  44. Kumar, P,Singh, DK(2014).In vitro anthelmintic activity of Allium sativum, Ferula asafoetida, Syzygium aromaticum and their active components against Fasciola gigantic.J Biol Earth Sci,4,B57-B65.
  45. Kumar, P,Singh, DK(2006).Molluscicidal activity of Ferula asafoetida, Syzygium aromaticum and Carum carvi and their active components against the snail Lymnaea acuminata.Chemosphere,63,1568-1574.
  46. Lee, CL,Chiang, CL,Cheng, LH,Liaw, CC(2009).Influenza A (H1N1) antiviral and cytotoxic agents from Ferula asafoetida.J Nat Prod,72,1568-1572.
  47. Mahendra, P,Bisht, S(2012).Ferula asafoetida: traditional uses and pharmacological activity.Pharmacogn Rev,6,141-146.
  48. Mallikarjuna, GU,Dhanalakshmi, S,Raisuddin, S,Ramesha Rao, A(2003).Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats.Breast Cancer Res Treat,81,1-10.
  49. Moghadam, FH,Dehghan, M,Zarepur, E(2014).Oleo gum resin of Ferula asafetida L. ameliorates peripheral neuropathy in mice.J Ethnopharmacol,154,183-189.
  50. Moghaddama, M,Farhadi, N(2015).Influence of environmental and genetic factors on resin yield, essential oil content and chemical composition of Ferula asafetida L. populations.J App Res Med Aromat Plants,2,69-76.
  51. Mostafa, Z,Soheil, P,Mahdi, J,Mahmoodi, S(2013).Antifangal effects of asafoetida seed essential oil on in vitro growth of five species of plant pathogenic fungi.Int Res J Appl Basic Sci.,4,1159-1162.
  52. Nassar, MI,Abu-Mustafa, EA,Ahmed, AA(1995).Sesquiterpene coumarins from Ferula asafoetida L.Pharmazie,10,766-767.
  53. Padhy, S,Rai, S,Lamba, NNHK,Upadhyay, M(2014).Spices as potent antibacterial agents against Staphylococcus aureus.ARPN J Sci Technol,4,46-51.
  54. Pangarova, TT,Zapesochnaya, GG(1975).Flavonoids of Ferula asafoetida.Chem Nat Compd,9,768.
  55. Panwar, R,Rana, S,Dhawan, DK,Prasad, KK(2015).Chemopreventive efficacy of different doses of Ferula asafoetida oleo-gum-resin against 1,2-dimethylhy-drazine (DMH) induced rat colon carcinogenesis.J Phytopharm,4,282-286.
  56. Patil, SD,Shinde, S,Kandpile, P,Jain, AS(2015).Evaluation of antimicrobial activity of asafoetida.Int J Pharm Sci Res,6,722-727.
  57. Platel, K,Srinivasan, K(2000).Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats.Nahrung,44,42-46.
  58. Pruthi, JS(1980).Spices and Condiments: Chemistry, Microbiology, Technology.New York:Academic Press.
  59. Rajanikanth, B,Ravindranath, B,Shankaranarayana, ML(1984).Volatile polysulphides of asafoetida.Phytochemistry,23,899-900.
  60. Ramakrishna, Rao R,Platel, K,Srinivasan, K(2003).In vitro influence of spices and spiceactive principles on digestive enzymes of rat pancreas and small intestine.Nahrung,47,408-412.
  61. Rani, A,Jain, S,Dureja, P(2009).Synergistic fungicidal efficacy of formulations of neem oil, nicotinic acid and Ferula asafoetida with α, β-unsaturated carbonyl compounds against Sclerotium rolfsii ITCC 5226 & Macrophomina phaseolina ITCC 0482.J Pestic Sci.,34,253-258.
  62. Sahebkar, A,Iranshahi, M(2010).Biological activities of essential oils from the genus Ferula (Apiaceae).Asian Biomed,4,835-847.
  63. Saleem, M,Alam, A,Sultana, S(2001).Asafoetida inhibits early events of carcinogenesis: a chemopreventive study.Life Sci.,68,1913-1921.
  64. Sepahi, E,Tarighi, S,Ahmadi, FS,Bagheri, A(2015).Inhibition of quorum sensing in Pseudomonas aeruginosa by two herbal essential oils from Apiaceae family.J Microbiol,53,176-180.
  65. Shrivastava, V,Bhardwaj, U,Sharma, V,Mahajan, N,Sharma, V,Shrivastava, G(2012).Antimicrobial activities of Asafoetida resin extracts (a potential Indian spice).J Pharm Res,5,5022-5024.
  66. Sitara, U,Niaz, I,Naseem, J,Sultana, N(2008).Antifungal effect of essential oils on in vitro growth of pathogenic fungi.Pak J Bot.,40,409-414.
  67. Srinivasan, K(2005).Role of spices beyond food flavouring: nutraceuticals with multiple health efforts.Food Rev Int,21,167-188.
  68. Srinivasan, K.(2013).Dietary spices as beneficial modulators of lipid profile in conditions of metabolic disorders and diseases.Food Funct,4,503-521.
  69. Takeoka, GR(ed.),Guntert, M(ed.),Engel, K-H(ed.)(2001).Aroma Active Compounds in Foods.Washington, DC:American Chemical Society.
  70. Tayeboon, GS,Tavakoli, F,Hassani, S,Khanavi, M,Sabzevari, O,Ostad, SN(2013).Effects of Cymbopogon citratus and Ferula asafoetida extracts on glutamate-induced neurotoxicity.In vitro Cell Dev Biol-Anim,49,706-715.
  71. Unnikrishnan, MC,Kuttan, R(1990).Tumour reducing and anticarcinogenic activity of selected spices.Cancer Lett.,51,85-89.
  72. Vijayalakshmi, Adiga S,Bhat, P,Chaturvedi, A,Bairy, KL,Kamath, S(2012).Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats.Indian J Pharmacol,44,82-87.
  73. Zargari, A(1996).Medicinal Plants.Tehran:Tehran University Publications.