题名

Alzheimer Disease: Clues from traditional and complementary medicine

DOI

10.1016/j.jtcme.2016.12.003

作者

Edwin L. Cooper;Melissa J. Ma

关键词

TCM ; eCAM ; Alzheimer ; Inflammation ; Treatment

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

7卷4期(2017 / 10 / 01)

页次

380 - 385

内容语文

英文

中文摘要

Despite modern medicine's incredible innovation and resulting accumulation of valuable knowledge, many of the world's most problematic diseases such as Alzheimer Disease (AD) still lack effective cures and treatments. Western medicine has revealed many genetic, cellular, and molecular processes that characterize AD such as protein aggregation and inflammation. As the need for novel and effective treatments increases, researchers have turned towards traditional medicine as a resource. Modern, evidence based research examining traditional and complementary remedies for AD has generated promising results within the last decade. Animal based products inhibiting cellular toxicity, anti-inflammatory nutraceuticals such as omega-3 fatty acids, and plant based compounds derived from herbal medicine demonstrate viability as neuroprotective treatments and possible application in developing pharmaceuticals. Analysis of antioxidant, anti-inflammatory, and neuroprotective phytochemicals used in various traditional medicines around the world reveal potential to ameliorate and prevent the devastating neurodegeneration observed in AD.

主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Alexander, AG,Marfil, V,Li, C.(2014).Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.Front Genet
  2. Anderson, KM,Olson, KE,Estes, KA,Flanagan, K,Gendelman, HE,Mosley, RL(2014).Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders.Transl Neurodegener,3(1),25.
  3. Bouleau, S,Tricoire, H(2015).Drosophila models of Alzheimer's disease: advances, limits, and perspectives.J Alzheimers Dis.,45(4),1015-1038.
  4. Chen, KC,Liu, YC,Lee, CC,Chen, CY(2014).Potential retinoid x receptor agonists for treating Alzheimer's disease from traditional Chinese medicine.Evid Based Complement Altern Med,2014,278493.
  5. Cherniack, EP(2011).Bugs as drugs, part two: worms, leeches, scorpions, snails, ticks, centipedes, and spiders.Altern Med Rev.,16(1),50-58.
  6. Cooper, EL(1994).Invertebrates can tell us something about senescence.Aging Clin Exp Res,6(1),5-23.
  7. Cooper, EL,Baculi, BS(1968).Degenerative changes in the annelid Lumbricus terrestis.J Gerontol,23,375-381.
  8. Cooper, EL,Balamurugan, M,Huang, CY(2012).Earthworms dilong: ancient, inexpensive, noncontroversial models may help clarify approaches to integrated medicine emphasizing neuroimmune systems.Evid Based Complement Altern Med,2012,164152.
  9. Farrokhnia, M,Nabipour, I.(2014).Marine natural products as acetylcholinesterase inhibitor: comparative quantum mechanics and molecular docking study.Curr Comput Aided Drug Des.,10(1),83-95.
  10. Frautschy, SA,Cole, GM(2010).Why pleiotropic interventions are needed for Alzheimer's disease.Mol Neurobiol,41(2-3),392-409.
  11. Gibellini, L,Pinti, M,Nasi, M(2011).Quercetin and cancer chemoprevention.Evidence Based Complement Altern Med,2011,591356.
  12. Glass, DJ,Arnold, SE(2012).Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology.Alzheimers Dement,8(4),343-351.
  13. Guzior, N,Wieckowska, AW,Panek, D,Malawska, B(2015).Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.Curr Med Chem,22(3),373-404.
  14. Heneka, MT,Carson, MJ,El Khoury, J(2015).Neuroinflammation in Alzheimer's disease.Lancet Neurol,14(4),388-405.
  15. Heneka, MT,Golenbock, DT,Latz, E(2015).Innate immunity in Alzheimer's disease.Nat Immunol,16(3),229-236.
  16. Huang, HJ,Chen, WL,Hsieh, RH,Hsieh-Li, HM(2014).Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic Alzheimer's mice.Evid Based Complement Altern Med,2014,813672.
  17. Kudoh, C,Arita, R,Honda, M(2015).Effect of ninjin'yoeito, a Kampo (traditional Japanese) medicine, on cognitive impairment and depression in patients with Alzheimer's disease: 2 years of observation.Psychogeriatrics,2015,85-92.
  18. Lee, S,Bang, SM,Lee, JW,Cho, KS(2014).Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models.Evid Based Complement Altern Med,2014,967462.
  19. Lee, SM,Yang, EJ,Choi, SM,Kim, SH,Baek, MG,Jiang, JH(2012).Effects of bee venom on glutamate-induced toxicity in neuronal and glial cells.Evid Based Complement Altern Med,2012,368196.
  20. Liu, AJ,Wang, SH,Hou, SY(2013).Evodiamine induces transient receptor potential vanilloid-1-mediated protective autophagy in U87-MG astrocytes.Evid Based Complement Altern Med,2013,354840.
  21. Liu, P,Kong, M,Yuan, S,Liu, J,Wang, P(2014).History and experience: a survey of traditional chinese medicine treatment for Alzheimer's disease.Evidence Based Complement Altern Med,2014,1-5.
  22. Nakajima, A,Aoyama, Y,Shin, EJ(2015).Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).Behav Brain Res,289,69-77.
  23. Nakajima, A,Ohizumi, Y,Yamada, K(2014).Anti-dementia activity of nobiletin, a citrus flavonoid: a review of animal studies.Clin Psychopharmacol Neurosci,12(2),75-82.
  24. Nishteswar, K,Joshi, H,Karra, RD(2014).Role of indigenous herbs in the management of Alzheimer's disease.Anc Sci Life,34(1),3-7.
  25. Orhan, IE(2012).Centella asiatica (L.) urban: from traditional medicine to modern medicine with neuroprotective potential.Evid Based Complement Altern Med,2012,946259.
  26. Pan, SY,Litscher, G,Gao, SH(2014).Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources.Evidence Based Complement Altern Med,2014,525340.
  27. Rasool, M,Malik, A,Qureshi, MS(2014).Recent updates in the treatment of neurodegenerative disorders using natural compounds.Evid Based Complement Altern Med,2014,979730.
  28. Sulistio, YA,Heese, K(2015).Proteomics in traditional chinese medicine with an emphasis on Alzheimer's disease.Evidence Based Complement Altern Med,2015,1-17.
  29. Thomas, J,Thomas, CJ,Radcliffe, J,Itsiopoulos, C(2015).Omega-3 fatty acids in early prevention of inflammatory neurodegenerative disease: a focus on Alzheimer's disease.BioMed Res Int,2015,1-13.
  30. Venkatesan, R,Ji, E,Kim, SY(2015).Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review.BioMed Res Int,2015,814068.
被引用次数
  1. Tushar P. Patil,Santram Lodhi,Kiran D. Patil,Gautam P. Vadnere(2020).Protective effects of luteolin on injury induced inflammation through reduction of tissue uric acid and pro-inflammatory cytokines in rats.Journal of Traditional and Complementary Medicine,10(1),60-69.