题名

Medicinal, biological and phytochemical properties of Gentiana species

DOI

10.1016/j.jtcme.2016.12.013

作者

Fatemeh Mirzaee;Amirsaeed Hosseini;Hossein Bakhshi Jouybari;Ali Davoodi;Mohammad Azadbakht

关键词

Gentiana ; Gentianaceae ; Iranian traditional medicine ; Anti-inflammatory ; Gentiopicroside

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

7卷4期(2017 / 10 / 01)

页次

400 - 408

内容语文

英文

中文摘要

Gentiana, a cosmopolitan and important genus of the Gentianaceae family, comprises 400 species distributed among the world. Based on the studies of Iranian traditional medicine texts, there are some promising bioactivities for this genus that is unknown in modern medicine and some of them are still the basis of new remedies. In traditional medicine texts, Gentiana's different exclusive forms of preparations are effective for treatment of some disorders such as menstrual over-bleeding, conjunctivitis, vitiligo, animals venom poisoning, injuries, infected wounds, pain and swelling of liver, spleen, stomach and sprains of muscles. There are some activities that are the same in traditional and modern medicine such as anti-inflammatory, hepatoprotective and diuretic effects. Phytochemical investigations on the title genus have led to characterization many secondary metabolites. Secoiridoidal and iridoid glycosides such as gentiopicroside, xanthones, monoterpene alkaloid; polyphenol and flavones are the constituents that have been shown the pharmacological activities in different gentian species. This article studies the Gentiana according to the Iranian traditional and modern medicine.

主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Lu, K-H,Liu, C-T,Raghu, R,Sheen, L-Y(2012).Therapeutic potential of Chinese herbal medicines in alcoholic liver disease.J Tradit Complement Med,2(2),115.
    連結:
  2. Aberham, A,Pieri, V,Croom, E,Ellmerer, E,Stuppner, H(2011).Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC-MS and RP-HPLC.J Pharm Biomed Analysis,54,517-525.
  3. Aghilialavi, H(2008).Makhzan Al Advieh.Tehran:Sabzarang.
  4. Amiri, MS,Joharchi, MR(2013).Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran.Avicenna J Phytomed,3(3),254-271.
  5. Ansari, A(1992).Ekhtiarate Badiei.Tehran:Pakhshe Razi.
  6. Ansari, S,Siddiqui, MA,Zaman, F.(1982).Therapeutic principles of liver diseases in Unani medicine.J Res Educ Indian Med
  7. Avicenna, H.(1987).The Canon of Medicine.
  8. Azadbakht, M,Azadbakht, M(2013).Medicinal Plants Systematic: According to APG Tehran.Arjmand Publication.
  9. Behera, M,Raina, R(2012).Gentiana kurroo Royle-A critically endangered bitter herb.Int J Med Aromatic Plants,2,22-29.
  10. Bironi, A(1979).Al-Seidaneh fi Al-Teb.Tehran, Iran:Academy of Persian Language and Literature.
  11. Brahmachari, G,Mondal, S,Gangopadhyay, A(2004).Swertia (Gentianaceae): chemical and pharmacological aspects.Chem Biodivers,1(11),1627-1651.
  12. Cappelletti, EM,Trevisan, R,Caniato, R(1982).External antirheumatic and antineuralgic herbal remedies in the traditional medicine of north-eastern Italy.J Ethnopharmacol.,6(2),161-190.
  13. Chen, F-P,Kung, Y-Y,Chen, Y-C(2008).Frequency and pattern of Chinese herbal medicine prescriptions for chronic hepatitis in Taiwan.J Ethnopharmacol,117(1),84-91.
  14. Chen, S,Yao, H,Han, J(2010).Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species.PLoS One,5(1),e8613.
  15. Chen, Y-J,Chen, Y-Y,Wu, C-Y,Chi, C-C(2016).Oral Chinese herbal medicine in combination with phototherapy for vitiligo: a systematic review and meta-analysis of randomized controlled trials.Complementary Ther Med,26,21-27.
  16. Colombo, M,Assisi, F,Della Puppa, T(2010).Most commonly plant exposures and intoxications from outdoor toxic plants.J Pharm Sci Res.,2,417-425.
  17. Darshan, S,Doreswamy, R(2004).Patented antiinflammatory plant drug development from traditional medicine.Phytotherapy Res,18(5),343-357.
  18. De Vos, P(2010).European materia medica in historical texts: longevity of a tradition and implications for future use.J Ethnopharmacol,132(1),28-47.
  19. Elpel, T.(2004).Botany in a Day: The Patterns Method of Plant Identification.Hops Press.
  20. Ernst, E(2000).Prevalence of use of complementary/alternative medicine: a systematic review.Bull World Health Organ,78(2),258-266.
  21. Favre, A,Yuan, Y-M,Küpfer, P,Alvarez, N(2010).Phylogeny of subtribe Gentianinae (Gentianaceae): biogeographic inferences despite limitations in temporal calibration points.Taxon,59,1701-1711.
  22. Ghahreman, A(1997).Flora of IRAN.Tehran:Research Institute of Forests and Rangelands.
  23. Ghahreman, A,Okhovvat, A.(2004).Matching the old medicinal plant names with scientific terminology.University of Tehran Press.
  24. Golzari, SE,Khan, ZH,Ghabili, K(2013).Contributions of Medieval Islamic physicians to the history of tracheostomy.Anesth Analg,116(5),1123-1132.
  25. Gurib-Fakim, A(2006).Medicinal plants: traditions of yesterday and drugs of tomorrow.Mol Asp Med,27(1),1-93.
  26. Hakim Momin, S(2012).Tohfa Al Momineen.Lucknow:Naval Kishore.
  27. Heinrich, M,Barnes, J,Gibbons, S,Williamson, EM.(2012).Fundamentals of Pharmacognosy and Phytotherapy.Edinburgh:ChurchillLivingstone.
  28. Ho, T,Pringle, J(1995).Gentianaceae.Flora China,16,1-139.
  29. Horn, CC(2008).Electrophysiology of vagal afferents.International Symposium on Olfaction and Taste,San Fransisco:
  30. Hungerer, K,Kadereit, J(1998).The phylogeny and biogeography of Gentiana L. sect. Ciminalis (Adans.) Dumort.: a historical interpretation of distribution ranges in the European high mountains.Perspect Plant Ecol Evol Syst,1,121-135.
  31. Ifrim, C,Mardari, C(2014).Anatomical peculiarities of the vegetative organs from two speies of the Gentianaceae family.Analele Stiintifice ale Universitatii "Al I Cuza"din Iasi,60,25.
  32. Isakovic, A,Jankovic, T,Harhaji, L(2008).Antiglioma action of xanthones from Gentiana kochiana: mechanistic and structure-activity requirements.Bioorg Med Chem,16(10),5683-5694.
  33. Kataeva, TN,Prokopyev, AS,Akinina, AA,Chernova, OD(2015).Seed morphology of some species in the family Gentianaceae.Biosci Biotechnol Res Asia,12,2287-2293.
  34. Katschinski, M(2000).Nutritional implications of cephalic phase gastrointestinal responses.Appetite,34(2),189-196.
  35. Krishnaiah, D,Sarbatly, R,Nithyanandam, R(2011).A review of the antioxidant potential of medicinal plant species.Food Bioprod Process,89,217-233.
  36. Kwak, WJ,Kim, JH,Ryu, KH,Cho, YB,Jeon, SD,Moon, CK(2005).Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS).Biol Pharm Bull,28(4),750-753.
  37. Li, Y,Ryan, P,Batey, R(2003).Traditional Chinese medicine prevents inflammation in CCl4-related liver injury in mice.Am J Chin Med,31(1),119-127.
  38. Lin, J-F,Liu, P-H,Huang, T-P(2014).Characteristics and prescription patterns of traditional Chinese medicine in atopic dermatitis patients: ten-year experiences at a medical center in Taiwan.Complement Ther Med,22(1),141-147.
  39. Liu, X-w,Cao, M,Liu, S-m(2011).Study on antipyretic effect and its mechanism of gentianine.Chin J Exp Tradit Med Formulae,24,038.
  40. Liu, X-w,Liu, S-m,Liu, C-f(2012).Sedative-hypnotic effect of gentianine and its influence on the content of 5-HT, GABA in mouse brain.Lishizhen Med Materia Medica Res,2,063.
  41. Mansoor, A,Asrar, M(2015).Evaluation of diuretic activity of extracts of Gentiana oliveri and gentianine in rats.J Pharm Pharm Sci,4,39-42.
  42. Menković, N,Šavikin-Fodulović, K,Bulatović, V(2002).Xanthones from Swertia punctata.Phytochemistry,61(4),415-420.
  43. Merckx, VS,Kissling, J,Hentrich, H(2013).Phylogenetic relationships of the mycoheterotrophic genus Voyria and the implications for the biogeographic history of Gentianaceae.Am J Bot,100(4),712-721.
  44. Mihailovic, V,Katanic, J,Misic, D(2014).Hepatoprotective effects of secoiridoidrich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats.Food Funct,5(8),1795-1803.
  45. Momen Tonekaboni, S.(2008).Tohfat Al-Momenin.Tehran, Iran:Shahr Publication.
  46. Mukherjee, PK,Wahile, A(2006).Integrated approaches towards drug development from Ayurveda and other Indian system of medicines.J Ethnopharmacol,103(1),25-35.
  47. Nasiri, E,Hosseinimehr, SJ,Azadbakht, M,Madani, SA(2014).A review of natural products for burn healing based on the Iranian traditional medicine.J Mazandaran Univ Med Sci,23,263-280.
  48. Nayebi, E,Azadbakht, M,Zamanfar, D(2016).Appetizing effect of Gentiana olivieri extract in children with anorexia.J Mazandaran Univ Med Sci,26(133),58-66.
  49. Niiho, Y,Yamazaki, T,Nakajima, Y(2006).Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats.J Nat Med.,60,82-88.
  50. Organization WH(2008).Organization WH. Traditional Medicine. Fact sheet Number 134. 2008..
  51. Petrovic, S,Leskovac, A,Joksic, G.(2008).Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro.Curr Sci,95(8),1035.
  52. Radanović, D,Marković, T,Aiello, N,Fusani, P(2014).Cultivation trials on Gentiana lutea L. in Southern and South-eastern Europe.J Appl Res Med Aromatic Plants,1,113-122.
  53. Razmjoue, D,Zarei, Z(2015).The study on some of ecological specifications of Gentiana olivieri a medicinal species in rangelands of Fars Province, Iran.J Agric Ecol Res Int,4,69-78.
  54. Robbers, JE,Tyler, VE(1999).Tyler's Herbs of Choice.Binghamton:The Hawthorn Press.
  55. Šavikin, K,Zdunić, G,Stević, T,Radanović, D,Janković, T(2009).Antimicrobial activity of Gentiana lutea L. extracts.ZeitschriftfürNaturforschung,C 64,339-342.
  56. Senol, FS,Tuzun, CY,Toker, G,Orhan, IE(2012).An in vitro perspective to cholinesterase inhibitory and antioxidant activity of five Gentiana species and Gentianella caucasea.Int J Food Sci Nutr,63(7),802-812.
  57. Singh, A.(2008).Phytochemicals of Gentianaceae: a review of pharmacological properties.Int J Pharm Sci Nanotechnol,1(1),33-36.
  58. Tabassum, S,Mahmood, S,Hanif, J,Hina, M,Uzair, B(2012).An overview of medicinal importance of Swertia chirayita.Int J Appl Sci Technol,2(1),298-304.
  59. Vaidya, H,Goyal, RK,Cheema, SK(2012).Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-gamma gene expression in 3T3-L1 cells.Phytother Res,27(4),624-627.
  60. Vinckier, S,Smets, E(2003).Morphological and ultrastructural diversity of orbicules in Gentianaceae.Ann Bot,92(5),657-672.
  61. Waltenberger, B,Liu, R,Atanasov, AG(2015).Nonprenylated xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as novel inhibitors of vascular smooth muscle cell proliferation.Molecules,20(11),20381-20390.
  62. Wani, BA,Ramamoorthy, D,Rather, MA(2013).Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (DeltaPsim) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents.Phytomedicine,20(8-9),723-733.
  63. Yun, Y,Lee, S,Kim, S,Choi, I(2013).Inpatient treatment for severe atopic dermatitis in a traditional Korean medicine hospital: introduction and retrospective chart review.Complement Ther Med,21(3),200-206.
  64. Zhang, Z-H,Liu, X-Q,Zhang, C(2016).Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation.Sci Rep,6
  65. Zhao, ZL,Dorje, G,Wang, ZT(2010).Identification of medicinal plants used as Tibetan traditional medicine jie-ji.J Ethnopharmacol,132(1),122-126.
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