Antiasthmatic related properties of Abrus precatorius leaves on various models

10.1016/j.jtcme.2016.12.007

Dnyaneshwar J. Taur；Rajendra N. Patil；Ravindra Y. Patil

Antiasthmatic activity ； Preconvulsive dysponea ； Antiinflammatory activity ； Got tracheal chain ； A. precatorius

Journal of Traditional and Complementary Medicine

7卷4期（2017 / 10 / 01）

428 - 432

英文

Objective: Asthma is a multifaceted inflammatory disorder which results into narrowing of airway with broncho-constriction and spasm. As the complex pathophysilogy of asthma, various animal models are generally used to investigate the immunological and physiological pathogenesis of disease. Abrus precatorius Linn (Fabacease) is a climbing shrub. The leaves and roots are sweet in taste and traditionally used for the treatment of asthma, bronchititis, and inflammation. A. precatorius possesses different pharmacological activities. Hence the objective of this study was to evaluate antiasthmatic activity of ethanol extract of A. precatorius leaves using various models. Methods: In present study ethanol extract of A. precatorius leaves was evaluated for antiasthmatic activity using carrageenan induced paw edema in rats [100-150 mg/kg], histamine induced bronchospasm in guinea pig [200-400 mg/kg] and histamine induced contraction of goat tracheal chain [2.5-25 μg/ml]. Results: Result of study revealed that ethanol extract of A. precatorius significantly exhibited anti-inflammatory effects in rats, oral treatment of extract on guinea pig significantly increases histamine induced preconvulsive dysponea times and the ethanol extract of plant increases got tracheal chain precontracted with histamine. Conclusion: Hence present study concludes that ethanol extract of A. precatorius possesses antiasthmatic activity.

1. Adelowotan, O,Aibinu, I,Adenipekun, E,Odugbemi, T(2008).The in-vitro antimicrobial activity of Abrus precatorius (L.) fabaceae extract on some clinical pathogens.Niger Postgrand Med J.,15(1),32-37.
2. Ahirwar, B,Ahirwar, D,Ram, A(2008).Antihistaminic activity of AVB-01-a polyherbal formulation.Pharm Mag,4(15),S46-S50.
3. Anam, EM(2001).Anti-inflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae).Phytomedicine,8(1),24-27.
4. Anonymous(2001).Anonymous. OECD Guidelines for the Testing of Chemicals. OECD 425. Acute Oral Toxicity-Modified Up and Down Procedure. Paris: Organisation for Economic Cooperation and Development; 2001..
5. Armitage, AM,Boswood, J,Large, BJ(1961).Thioxanthines with potent bronchodialator and coronary dialator properties.Br Pharm Chemother,16,59-76.
6. Bhutia, SK,Mallick, SK,Maiti, TK(2009).In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice.Phytomedicine,16(8),776-782.
7. Bobbarala, V,Vadlapudi, V(2009).Abrus precatorius L. seed extracts antimicrobial properties against clinically important bacteria.Int J Pharm Tech Res,1(4),1115-1118.
8. Chaudhari, KN,Lahiri, C(1971).Role of goat trachea for an isolated tracheal chain preparation.Indian J Pharmacol,6,149-151.
9. Di Rosa, M(1972).Biological properties of carrageenan.J Pharm Pharmacol,24(2),89-102.
10. Ghosh, D,Maiti, TK(2007).Immunomodulatory and anti-tumor activities of native and heat denatured Abrus agglutinin.Immunobiology,212(7),589-599.
11. Goetzl, EJ(1980).Mediators of immediate hypersensitivity derived from arachidonic acid.N Engl J Med.,303,822-825.
12. Kirtikar, KR,Basu, BD(1987).Indian Medicinal Plants.Dehradun, India:International Book Distributor.
13. Kulshrestha, S,Misra, SS,Sharma, AL,Sharma, P,Singhal, D.(1983).Response of the goat trachea to some autonomic drugs.Indian J Pharmacol,15(2),107-110.
14. Mali, RG,Mahajan, SG,Mehta, AA(2008).Studies on bronchodilatory effect of Lepidium sativum against allergen induced bronchospasm in Guinea pigs.Pharm Mag,4(15),189-192.
15. Nwodo, OF,Alumanah, EO(1991).Studies on Abrus precatorius seeds. II: antidiarrhoeal activity.J Ethnopharmacol,31(3),395-398.
16. Ramnath, V,Kuttan, G,Kuttan, R(2002).Immunopotentiating activity of abrin, a lectin from Abrus precatorius Linn.Indian J Exp Biol,40(8),910-913.
17. Rosa Di, M,Willough, DA(1971).Screens for anti-inflammatory drugs.J Pharm Pharmac,23,297-298.
18. Ross, IA(2005).Medicinal plants of the world: chemical constituents, traditional and modern medicinal uses.N J.:Humana Press Inc.
19. Saxena, Prachi,Saxena, Priyanka(2014).In-vitro and in-vivo evaluation of anti asthmatic activity of rhizomes extract of Acorus calamus (Linn.) in Guinea pigs.Res J Pharm Sci.,3(5),1-6.
20. Taur, DJ,Patil, RY(2012).Antihistaminic activity of Abrus precatorius using clonidine induced catalepsy in mice.Orient Pharm Exp Med,12,11-14.
21. Taur, DJ,Patil, RY(2011).Mast cell stabilizing and antiallergic activity of Abrus precatorius in the management of asthma.Asian Pac J Trop Med,2011,46-49.
22. Taur, DJ,Patil, RY(2010).Different screening methods for asthma: a review.J Pharm Res,3(12),2828-2830.
23. Taur, DJ,Patil, RY(2012).Effect of Abrus precatorius leaves on milk induced leukocytosis and eosinophilia in the management of asthma.Asian Pac J Trop Biomed,2012,S40-S42.
24. Zore, GB,Award, V,Thakre, AD(2007).Activity-directed-fractionation and isolation of four antibacterial compounds from Abrus precatorius L. roots.Nat Prod Res,21(9),838-845.

1. R. Balaraman,Kilambi Pundarikakshudu,Ghanshyam Parmar(2019).Anti-anaphylactic and antiasthmatic activity of Euphorbia thymifolia L. on experimental animals.Journal of Traditional and Complementary Medicine,9(1),60-65.