题名

Promising effect of Rosa damascena extract on high-fat diet-induced nonalcoholic fatty liver

DOI

10.1016/j.jtcme.2017.01.008

作者

Ida Davoodi;Roja Rahimi;Mohammad Abdollahi;Fatemeh Farzaei;Mohammad Hosein Farzaei;Zahra Memariani;Fariba Najafi

关键词

Fatty liver ; Oxidative stress ; Rosa damascene ; Dietary supplement ; Medicinal plant

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

7卷4期(2017 / 10 / 01)

页次

508 - 514

内容语文

英文

中文摘要

NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages. Rosa damascena Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract of R. damascena on animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase (p < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels. R. damascena significantly reduced the elevation of final body weight, liver fat accumulation, TG, TC, LDL-C concentrations and hepatic enzymes (p < 0.05). Histopathological examination of hepatic tissue confirmed the therapeutic effect of R. damascena. Improvement of total antioxidant power activity, total thiol content, MPO enzyme activity, and also lipid peroxidation were also considered in treated animals (p < 0.05). HPLC analysis showed that phenolic compounds including gallic acid, quercetin and syringic acid are the main bioactive compounds of R. damascena hydroalcoholic extract. In conclusion, R. damascena dietary supplementation has a therapeutic effect in NAFLD. Improvement of oxidative stress associated damage in liver tissue is among the main pharmacological mechanisms involved in therapeutic activity of the plant.

主题分类 醫藥衛生 > 中醫藥學
参考文献
  1. Achuthan, CR,Babu, BH,Padikkala, J(2003).Antioxidant and hepatoprotective effects of Rosa damascena.Pharm Biol,41(5),357-361.
  2. Akhlaghi, M(2016).Non-alcoholic fatty liver disease: beneficial effects of flavonoids.Phytother Res,30(10),1559-1571.
  3. Bahramsoltani, R,Farzaei, MH,Farahani, MS,Rahimi, R(2015).Phytochemical constituents as future antidepressants: a comprehensive review.Rev Neurosci,26(6),699-719.
  4. Boskabady, MH,Shafei, MN,Saberi, Z,Amini, S(2011).Pharmacological effects of rosa damascena.Iran J Basic Med Sci.,14(4),295-307.
  5. Bugianesi, E,McCullough, AJ,Marchesini, G(2005).Insulin resistance: a metabolic pathway to chronic liver disease.Hepatology,42,987-1000.
  6. Chao, J,Huo, TI,Cheng, HY(2014).Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice.PloS One,9(6),e96969.
  7. Cohen, JC,Horton, JD,Hobbs, HH(2011).Human fatty liver disease: old questions and new insights.Science,332,1519-1523.
  8. Del Ben, M,Polimeni, L,Baratta, F,Pastori, D,Angelico, F(2017).The role of nutraceuticals for the treatment of non-alcoholic fatty liver disease.Brit J Clin Pharm,83(1),88-95.
  9. Dong, D,Zhang, S,Yin, L(2013).Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.Food Chem Toxicol,62,120-130.
  10. Fan, JG(2010).Epidemiological studies of nonalcoholic fatty liver disease in China.Chin J Postgrad Med,33,4-6.
  11. Farzaei, MH,Abbasabadi, Z,Sahms-Ardekani, MR,Abdollahi, M,Rahimi, R(2014).A comprehensive review of plants and their active constituents with wound healing activity in traditional Iranian medicine.Wounds,26(7),197-206.
  12. Farzaei, MH,Abdollahi, M,Rahimi, R(2015).Role of dietary polyphenols in the management of peptic ulcer.World J Gastroenterol,21(21),6499-6517.
  13. Farzaei, MH,Khanavi, M,Moghaddam, G(2014).Standardization of Tragopogon graminifolius DC. Extract based on phenolic compounds and antioxidant activity.J Chem,2014
  14. Farzaei, MH,Rahimi, R,Abbasabadi, Z,Abdollahi, M(2013).An evidence-based review on medicinal plants used for the treatment of peptic ulcer in traditional Iranian medicine.Int J Pharmacol,9(2),108-124.
  15. Farzaei, MH,Rahimi, R,Farzaei, F,Abdollahi, M(2015).Traditional medicinal herbs for the management of diabetes and its complications: an evidence-based review.Int J Pharmacol,11(7),874-887.
  16. Gaggini, M,Morelli, M,Buzzigoli, E,DeFronzo, RA,Bugianesi, E,Gastaldelli, A(2013).Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease.Nutrients,5(5),1544-1560.
  17. Garcia-Ruiz, C,Colell, A,Morales, A,Kaplowitz, N,Fernandez, Checa, JC(1995).Role of oxidative stress generated form the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.Mol Pharmacol,48,825-834.
  18. Gudin, S.(2000).Rose: genetics and breeding.J Plant Breed,17,159-189.
  19. Kobori, M,Masumoto, S,Akimoto, Y,Oike, H(2011).Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice.Mol Nutr Food Res,55(4),530-540.
  20. Liu, YT,Lu, BN,Peng, JY(2011).Hepatoprotective activity of the total flavonoids from Rosa laevigata Michx fruit in mice treated by paracetamol.Food Chem,125(2),719-725.
  21. Loghmani-Khouzani, H,Sabzi-Fini, O,Safari, J(2007).Essential oil composition of Rosa damascena Mill cultivated in central Iran.Sci Iran,14,316-319.
  22. Marchesini, G,Brizi, M,Morselli-Labate, AM(1999).Association of nonalcoholic fatty liver disease with insulin resistance.Am J Med,107(5),450-455.
  23. Memariani, Z,Amin, G,Moghaddam, G,Hajimahmoodi, M(2015).Comparative analysis of phenolic compounds in two samples of Rosa damascena by HPLC.Int J Biosci,7(1),112-118.
  24. Moore, JB(2010).Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome.Proc Nutr Soc,69(02),211-220.
  25. Navaei-Nigjeh, M,Rahimifard, M,Pourkhalili, N(2012).Multi-organ protective effects of cerium oxide nanoparticle/selenium in diabetic rats: evidence for more efficiency of nanocerium in comparison to metal form of cerium.Asian J Anim Vet Adv.,7(7),605-612.
  26. Nseir, W,Hellou, E,Assy, N.(2014).Role of diet and lifestyle changes in nonalcoholic fatty liver.World J Gastroenterol,20(28),9338-9344.
  27. Pisonero-Vaquero, S,González-Gallego, J,Sánchez-Campos, S,García-Mediavilla, MV(2015).Flavonoids and related compounds in non-alcoholic fatty liver disease therapy.Curr Med Chem,22(25),2991-3012.
  28. Rahimi, R,Baghaei, A,Baeeri, M(2013).Promising effect of Magliasa, a traditional Iranian formula, on experimental colitis on the basis of biochemical and cellular findings.World J Gastroenterol,19(12),1901.
  29. Rasool, MK,Sabina, EP,Ramya, SR(2010).Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice.J Pharm Pharm,62(5),638-643.
  30. Sanna, C,Rosso, C,Marietti, M,Bugianesi, E(2016).Non-alcoholic fatty liver disease and extra-hepatic cancers.Int J Mol Biol,17(5),717.
  31. Schiber, A,Mihalev, K,Berardini, N,Mollov, P,Carle, R(2005).Flavonol glycosides from distilled petals of Rosa damascena Mill.Z Naturforsch C.,60(5-6),379-384.
  32. Sedighi(2014).In vitro impact of hydroalcoholic extract of Rosa damascena Mill. On rat ileum contractions and the mechanisms involved.Int J Prev Med,5(6),767-775.
  33. Shirazi, M,Mohebitabar, S,Bioos, S(2017).The effect of topical Rosa damascene (rose) oil on pregnancy-related low back pain: a randomized controlled clinical trial.J Evid Based Complement Altern Med,22(1),120-126.
  34. Shokoohinia, Y,Rashidi, M,Hosseinzadeh, L,Jelodarian, Z(2015).Quercetin-3-O-β-d-glucopyranoside, a dietary flavonoid, protects PC12 cells from H 2 O 2-induced cytotoxicity through inhibition of reactive oxygen species.Food Chem,167,162-167.
  35. Soleimani, H,Ranjbar, A,Baeeri, M(2008).Protection by Nigella sativa L. of CCL 4-induced toxic nitrosative stress in rats.Toxicol Lett.,180,S39.
  36. Yeh, CT,Yen, GC(2006).Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by phenolic acids in rats.J Nutr Biochem,17(8),561.
  37. Yesilova, Z,Yaman, H,Oktenli, C(2005).Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease.Am J Gastroenterol,100,850-855.
被引用次数
  1. Abdul Mobeen,A Khaleel Ahmad(2021).The efficacy and safety of herbal combination of Unani Medicine in chronic urticaria: A randomized, controlled study.Journal of Traditional and Complementary Medicine,11(4),303-310.
  2. Sandeep Das,Dipayan Choudhuri(2020).Calcium supplementation shows a hepatoprotective effect against high-fat diet by regulating oxidative-induced inflammatory response and lipogenesis activity in male rats.Journal of Traditional and Complementary Medicine,10(5),511-519.
  3. Suraphan Panyod,Lee-Yan Sheen(2020).Beneficial effects of Chinese herbs in the treatment of fatty liver diseases.Journal of Traditional and Complementary Medicine,10(3),260-267.