Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress

10.1016/j.jtcme.2017.03.004

Hironori Fujiwara；Ryohei Tsushima；Ryo Okada；Suresh Awale；Ryota Araki；Takeshi Yabe；Kinzo Matsumoto

Attention-deficit/hyperactivity disorder ； Social isolation mice ； Sansoninto ； Early growth response 1 ； Sociability deficit

Journal of Traditional and Complementary Medicine

8卷1期（2018 / 01 / 01）

81 - 88

英文

Social isolation (SI) mice exhibit behavioral abnormalities such as impairments of sociability- and attention-like behaviors, offering an animal model of neurodevelopmental disorders such as attention-deficit/ hyperactivity disorder (ADHD). This study aimed to identify the effects of Sansoninto (SST; 酸棗仁湯suān zǎo rén tāng) on the psychiatric symptoms related to ADHD using SI mice. Four-week-old mice were socially isolated during the experimental period, and SST administration (800 or 2400 mg/kg, p.o.) was started at 2 weeks after starting SI. SST ameliorated SI-induced impairments of sociability- and attention-like behaviors in a dose-dependent manner, and tended to ameliorate contextual- and auditory-dependent fear memory deficit. Moreover, the expression level of Egr-1 was down-regulated by SI stress, and was restored by a high dose of SST. These findings suggest that SST is useful for improvement of psychiatric disorders such as ADHD.

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1. Takuya Watanabe,Shutaro Katsurabayashi,Katsunori Iwasaki,Kaori Kubota,Hiroshi Moriyama,Hikari Iba(2022).Sansoninto attenuates aggressive behavior and increases levels of homovanillic acid, a dopamine metabolite, in social isolation-reared mice.Journal of Traditional and Complementary Medicine,12(3),243-249.