题名

Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

DOI

10.1016/j.jtcme.2018.01.006

作者

P. Annécie Benatrehina；Li Pan；C. Benjamin Naman；Jie Li；A. Douglas Kinghorn

关键词

Açaí ； Noni ； Mangosteen ； Black chokeberry ； Maqui berry

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

8卷2期（2018 / 04 / 01）

页次

267 - 277

内容语文

英文
中文摘要

In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases. Laboratory studies on açaí have shown both its antioxidant and anti-inflammatory activities in vitro, and more importantly, its neuroprotective properties in animals. Anthraquinones and iridoid glucosides isolated from noni fruit induce the phase II enzyme quinone reductase (QR), and noni fruit juice exhibited antitumor and antidiabetic activities in certain animal models. Antitumorigenic effects of mangosteen in animal xenograft models of human cancers have been attributed to its xanthone content, and pure α-mangostin was shown to display antineoplastic activity in mice despite a reported low oral bioavailability. Work on the less extensively investigated black chokeberry and maqui berry has focused on recent isolation studies and has resulted in the identification of bioactive secondary metabolites with QR-inducing and hydroxyl-radical scavenging properties. On the basis of the safety studies and toxicity case reports described herein, these fruits may be generally considered as safe. However, cases of adulteration found in a commercialized açaí product and some conflicting results from mangosteen safety studies warrant further investigation on the safety of these marketed botanical dietary supplements.
主题分类 醫藥衛生 > 中醫藥學
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