Impact of green tea extract on serum lipid of postmenopausal women: A randomized controlled trial

10.1016/j.jtcme.2017.07.005

Mitra Tadayon；Somaneh Movahedi；Parvin Abedi；Amir Syahpoosh

Low density lipoprotein ； Triglyceride ； High density lipoprotein ； Total cholesterol ； Green tea extract

Journal of Traditional and Complementary Medicine

8卷3期（2018 / 07 / 01）

391 - 395

英文

Background: This study aimed to evaluate the impact of green tea extract on serum lipid level in postmenopausal women. Method: In this randomized controlled trial 100 postmenopausal women with an abnormality in at least one lipid profile were recruited and randomly assigned to one of the two groups: green tea extract (n = 50) and control group (n = 50). The intervention group received two capsules (400 mg) of green tea extract two times daily; the control group received a placebo for 4 weeks. The serum level of the lipid profile (total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride, and fasting blood sugar) was measured at baseline and 4 weeks after intervention. Results: In total, 79 women completed the study. The mean total cholesterol in the green tea group was significantly decreased after 4 weeks of intervention (mean difference -18.1 vs. -5 mg/dL in the green tea and placebo groups, p ＜ 0.04). The triglyceride and LDL also decreased significantly in the green tea group compared to the control group (p = 0.002 and p = 0.04 respectively). The level of HDL and fasting blood sugar did not change within the group and between groups. Conclusion: Green tea extract is cost-effective way to decrease lipid profile in postmenopausal women without major side effects. Using this herb is recommended in women who have slight lipid profile abnormalities.

1. Abdollahi, AA,Qorbani, M,Asayesh, H(2013).The menopausal age and associated factors in Gorgan, Iran.Med J Islam Repub Iran,27(2),50-56.
2. Ahmad, RS,Sadiq Butt, M,Tauseef Sultan, M(2015).Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia.J Transl Med,13,79.
3. Anderson, JW,Johnstone, BM,Cook-Newell, ME(1995).Meta-analysis of the effects of soy protein intake on serum lipids.N Engl J Med.,333,276-282.
4. Bade, G,Shah, S,Nahar, P(2014).Effect of menopause on lipid profile in relation to body mass index.Chron Young Sci.,5,20-24.
5. Derby, CA,Crawford, SL,Pasternak, RC(2009).Lipid changes during the meno-pause Transition in relation to age and Weight the study of Women's health across the Nation.Am J Epidemiol,169(11),1352-1361.
6. Fauci, A,Kasper, D,Hauser, E(2011).Harrisonʹs Internal Medicine (Metabolic and Endocrine Disorder).New York:Mc Graw-Hill.
7. Greendale, GA,Hogan, P,Kritz-Silverstein, D(1995).Age at menopause in women participating in the postmenopausal estrogen/progestins interventions (PEPI) trial: an example of bias introduced by selection criteria.Menopause,2,27-34.
8. Khan, N,Mukhtar, H.(2013).Tea and health: studies in humans.Curr Pharm Des,19(34),6141-6147.
9. Koo, SL,Noh, SK(2007).Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect.J Nutr Biochem,18(3),179-183.
10. Lobo, RA(1991).Effects of hormonal replacement on lipids and lipoproteins in post-menopausal women.J Clin Endocrinol Metab,73,925-930.
11. Onakpoya, I,Spencer, E,Heneghan, C(2014).The effect of green tea on blood pressure and lipid profile: a systematic review and meta-analysis of randomized clinical trials.Nutr Metab Cardiovasc Dis,24(8),823-836.
12. Rosano, GM,Vitale, C,Marazzi, G(2007).Menopause and cardiovascular disease: the evidence.Climacteric,10(1),19-24.
13. Rose, April Lynn(2015).University of Minnesota.
14. Saha, KR,Rahman, MM,Paul, AR(2013).Changes in lipid profile of post-menopausal women.Mymensingh Med J.,22(4),706-711.
15. Suliburska, J,Bogdanski, P,Szulinska, M(2012).Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients.Biol Trace Elem Res,149(3),315-322.
16. Taffe, JR,Dennerstein, L(2002).Menstrual patterns leading to the final menstrual period.Menopause,9,32.
17. U.S. Department of Health and Human Services Public Health Service, National Institutes of Health National Heart, Lung, and Blood Institute(2001).U.S. Department of Health and Human Services Public Health Service, National Institutes of Health National Heart, Lung, and Blood Institute. ATP III Guidelines At-a-glance Quick Desk Reference NIH Publication No. 01-3305. May 2001..
18. Walkowiak, J,Bajerska, J,Kargulewicz, A(2013).Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans.Acta Biochim Pol,60(3),481-483.
19. Walsh, BW,Schiff, I,Rosner, B(1991).Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins.N Engl J Med,325,1196-1204.
20. Wilson, PW,Abbott, RD,Castelli, WP(1988).High density lipoprotein cholesterol and mortality. The Framingham Heart Study.Arteriosclerosis,8(6),737-741.
21. Wu, AH,Spicer, D,Stanczyk, FZ(2012).Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women.Cancer Prev Res,5,393.

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