题名

Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved

DOI

10.1016/j.jtcme.2020.02.006

作者

Letizia Vallino；Alessandra Ferraresi；Chiara Vidoni；Eleonora Secomandi；Andrea Esposito；Danny N. Dhanasekaran；Ciro Isidoro

关键词

Nutraceutical ； Cancer ； Epigenetics ； Cell metabolism ； Warburg effect ； Autophagy

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

10卷3期（2020 / 05 / 01）

页次

217 - 229

内容语文

英文
中文摘要

Background and aim: Non-coding RNAs control cell functioning through affecting gene expression and translation and their dysregulation is associated with altered cell homeostasis and diseases, including cancer. Nutraceuticals with anti-cancer therapeutic potential have been shown to modulate non-coding RNAs expression that could impact on the expression of genes involved in the malignant phenotype. Experimental procedure: Here, we report on the microarray profiling of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and on the associated biochemical pathways and functional processes potentially modulated in OVCAR-3 ovarian cancer cells exposed for 24 h to Resveratrol (RV), a nutraceutical that has been shown to inhibit carcinogenesis and cancer progression in a variety of human and animal models, both in vitro and in vivo. Diana tools and Gene Ontology (GO) pathway analyses along with Pubmed literature search were employed to identify the cellular processes possibly affected by the dysregulated miRNAs and lncRNAs. Results and conclusion: The present data consistently support the contention that RV could exert antineoplastic activity via non-coding RNAs epigenetic modulation of the pathways governing cell homeostasis, cell proliferation, cell death and cell motility.
主题分类 醫藥衛生 > 中醫藥學
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