Obesity preventive function of novel edible mushroom, Basidiomycetes-X (Echigoshirayukidake): Manipulations of insulin resistance and lipid metabolism

10.1016/j.jtcme.2020.03.004

Mst Afifa Khatun；Shinji Sato；Tetsuya Konishi

Echigoshirayukidake (BDM-X) ； Obesity ； Type 2 diabetes ； Insulin resistance ； Adiponectin

Journal of Traditional and Complementary Medicine

10卷3期（2020 / 05 / 01）

245 - 251

英文

Echigoshirayukidake is an edible mushroom found in Uonuma, Japan in 1994. It was assigned to a new species of Basidiomycetes (BDM-X) but is uniquely defect of forming bashidium. The high antioxidant activity and β-glucan content of BDM-X suggest possible functions preventing type 2 diabetes. In the present study, anti-obesity and insulin resistance preventive functions of BDM-X were examined using genetically defined obese model rat, OLETF (Otsuka Long Evans Tokushima Fatty) by feeding regular diet with and without supplementation of 5% dried BDM-X powder (BDMP) for 15 weeks. BDMP supplementation to the diet significantly (p ＜ 0.01) suppressed the body weight gain and also visceral fat accumulation during the feeding period compared to control diet. Simultaneously, the insulin resistance and the plasma levels of adiponectin and triglycerides were significantly (p = 0.003) ameliorated in the BDMP supplemented diet group. A statistical multivariate analysis showed the weight of three types of adipose tissue (epididymal, retroperirenal, and mesenteric fat) positively correlated with HOMA-IR (Homeostasis Model Assessment of Insulin Resistance), and negatively correlated with plasma adiponectin. These results indicate BDM-X is a new resource applicable to the functional foods or the complementary biomedicines to prevent metabolic syndromes leading to type 2 diabetes.

1. Anderson, RA,Evans, ML,Ellis, GR(2001).The relationships between post-prandial lipidemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes.Atherosclerosis,154,475-483.
2. Benalla, W,Bellahcen, S,Bnouham, M(2010).Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors.Curr Diabetes Rev.,6(4),247-254.
3. Berg, AH,Combs, TP,Scherer, PE(2002).ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism.Trend Endocrinol metab,13(2),84-89.
4. Bloch-Damti, A,Bashan, N(2005).Proposed mechanisms for the induction of insulin resistance by oxidative stress.Antioxidants Redox Signal,7,1553-1567.
5. Chin, YW,Lim, SW,Kim, SH(2003).Hepatoprotective pyrrole derivatives of Lycium chinense fruits.Bioorg Med Chem Lett,13(1),79-81.
6. Eckel, RH,Grundy, SM,Zimmet, PZ(2005).The metabolic syndrome.Lancet,365,1415-1428.
7. Evans, JL,Goldfine, ID,Maddux, BA,Grodsky, GM(2003).Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?.Diabetes,52(1),1-8.
8. Evans, JL,Goldfine, ID,Maddux, BA,Grodsky, GM(2002).Oxidative stress and stressactivated signaling pathways: a unifying hypothesis of type 2 diabetes.Endocr Rev,23,599-622.
9. Fonseca, VA(2005).The metabolic syndrome, hyperlipidemia, and insulin resistance.Clin Cornerstone,7(2-3),61-72.
10. Guerrero-Romero, F,Villalobos-Molina, R,Jiménez-Flores, JR(2016).Fasting triglycerides and glucose index as a diagnostic test for insulin resistance in young adults.Arch Med Res.,47(5),382-387.
11. Gulcelik, NE,Usman, A,Gurlek, A(2009).Role of adipocytokines in predicting the development of diabetes and its late complications.Endocrine,36,397-403.
12. Han, S,Jiao, J,Zhang, W(2015).Dietary fiber prevents obesity-related liver lipotoxicity by modulating sterol-regulatory element binding protein pathway in C57BL/6J mice fed a high-fat/cholesterol diet.Sci Rep,5,15256.
13. Hess, JM,Wang, Q,Krafta, C,Slavin, JL(2017).Impact of Agaricus bisporus mushroom consumption on satiety and food intake.Appetite,117,179-185.
14. Hoffman, RP(2006).Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents.Diabetes Care,29(6),1402-1404.
15. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Available at: http://www.idf.org/metabolicsyndrome; 2006.
16. Kadowaki, T,Yamauchi, T,Kubota, N,Hara, K,Ueki, K,Tobe, K(2006).Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.J Clin Invest,116,1784-1792.
17. Karpe, F,Dickmann, JR,Frayn, KN(2011).Fatty acids, obesity, and insulin resistance: time for a reevaluation.Diabetes,60,2441-2449.
18. Kawano, K,Hirashima, T,Mori, S,Natori, T(1994).OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain.Diabetes Res Clin Pract,24(Suppl),S317-S320.
19. Khoury, DE,Cuda, C,Luhovyy, BL,Anderson, GH(2012).Beta glucan: health benefits in obesity and metabolic syndrome.J Nutri Met,2012,851362.
20. Kim, GN,Kwon, YI,Jang, HD(2011).Mulberry leaf extract reduces postprandial hyperglycemia with few side effects by inhibiting a-glucosidase in normal rats.J Med Food.,14(7-8),712-717.
21. Lemieszek, M,Rzeski, W(2012).Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class.Contemp Oncol.,16(4),285-289.
22. Matthews, DR,Hosker, JP,Rudenski, AS,Naylor, BA,Treacher, DF(1985).Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man.Diabetologia,28,412-419.
23. Newsholme, P,Haber, EP,Hirabara, SM(2007).Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.J Physiol,583(Pt 1),9-24.
24. Niswender, KD,Shiota, M,Postic, C,Cherrington, AD,Magnuson, MA(1997).Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.J Biol Chem,272,22570-22575.
25. Noushmehr, H,D’Amico, E,Farilla, L(2005).Fatty acid translocase (FAT/CD36) is localized on insulin containing granules in human pancreatic β-cells and mediates fatty acid effects on insulin secretion.Diabetes,54(2),472-481.
26. Olefsky, J,Farquhar, JW,Reaven, G(1973).Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects.Diabetes,22,507-513.
27. Purves, RD(1992).Optimum numerical integration methods for estimation of areaunder-the-curve (AUC) and area-under-the-moment-curve (AUMC).J Pharmacokinet Biopharm,20,211-227.
28. Sadler, M(2003).Nutritional properties of edible fungi.British Nutrition Foundation Nutrition Bulletin,28,305-308.
29. Sakaguchi, K,Takeda, K,Maeda, M(2016).Glucose area under the curve during oral glucose tolerance test as an index of glucose intolerance.Diabetol Int,7,53-58.
30. Stern, MP,Williams, K,Gonzalez-Villalpando, C,Hunt, KJ,Haffner, SM(2004).Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease?.Diabetes Care,27(11),2676-2681.
31. Tang, H,Kalita, P,dwivedi, P,Das, AK,Namsa, ND(2012).Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya northeast, India.J Ethnopharmacol,141(3),786-795.
32. Teno, S,Uto, Y,Nagashima, H(2000).Association of post-prandial hyper-triglyceridemia and carotid intima-media thickness in patients with type 2 diabetes.Diabetes Care,23,1401-1406.
33. Triggle, CR,Ding, H(2014).Cardiovascular impact of drugs used in the treatment of diabetes.Ther Adv Chronic Dis.,5(6),245-268.
34. Vetchinkina, E,Shirokov, A,Bucharskaya, A(2016).Antitumor activity of extracts from medicinal basidiomycetes mushrooms.Int J Med Mushrooms,18(11),955-964.
35. Vossen, M,Todter, K,Altenburg, C,Beisiegel, U,Scheja, L(2011).Plasma triglycerides after oral glucose load specifically associate with metabolic risk markers in healthy type 2 diabetes offspring.Atherosclerosis,217(1),214-219.
36. Wang, H,Storlien, LH,Huang, XF(2002).Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression.Am J Physiol Endocrinol Metab,282,E1352-E1359.
37. Wang, ZQ,Zuberi, A,Zhang, XH(2007).Effects of dietary fibers on weight gain, carbohydrate metabolism and gastric ghrelin gene expression in high fat diet fed mice.Metabolism,56(12),1635-1642.
38. Wasser, SP(2002).Medical mushrooms as a source of antitumor and immunomodulating polysaccharides.Appl Microbiol Biotechnol,60,258-274.
39. Watanabe, T,Nakajima, Y,Konishi, T(2008).In vitro and in vivo anti-oxidant activity of hot water extract of basidiomycetes-X, newly identified edible fungus.Biol Pharm Bull,31(1),111-117.
40. Yamauchi, T,Kamon, J,Minokoshi, Y(2002).Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.Nat Med,8(11),1288-1295.
41. Yatagai, T,Nagasaka, S,Taniguchi, A(2003).Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus.Metabolism,52(10),1274-1278.
42. Yoshihara, F,Kojima, M,Hosoda, H,Nakazato, M,Kangawa, K(2002).Ghrelin. A novel peptide for growth hormone release and feeding regulation.Curr Opin Clin Nutr Metab Care,5(4),391-395.

1. Sushil Kumar,Reenu Punia,Rama Kant,Rajesh Agarwal,Nichole Reisdorph,Michael Wempe,Michael G. Edwards,Laura Saba,Komal Raina,Dominique Reed,Dileep Kumar,Charmion Cruickshank-Quinn,Chapla Agarwal,Boris Tabakoff(2022).Transcriptome and metabolome changes induced by bitter melon (Momordica charantia)- intake in a high-fat diet induced obesity model.Journal of Traditional and Complementary Medicine,12(3),287-301.