题名

Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect

DOI

10.1016/j.jtcme.2020.03.003

作者

Anchalee Prasansuklab；James M. Brimson；Tewin Tencomnao

关键词

Glutamate ； Neuroprotective ； Neurotoxicity ； Alzheimer's disease ； Oxidative stress ； Plant extract ； Herbal medicine ； Traditional medicine

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

10卷3期（2020 / 05 / 01）

页次

301 - 308

内容语文

英文
中文摘要

Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade. As NDD is closely linked to old age, the rapid worldwide growth in the aging population contributes to an increasing number of people with one of these incurable diseases and therefore it is considered a significant global health issue. There is an urgent need for novel effective treatments for NDD, and many new research strategies are centered on traditional medicine as an alternative or complementary solution. Several previous findings have suggested that glutamate toxicity drives neurodegeneration in many NDD, and the medicinal plants with anti-glutamate toxicity properties can be potentially used for their treatment. In order to obtain data relating to natural products against glutamate toxicity, six candidate plant species of Thailand were identified. Studies utilizing these herbs were searched for using the herb name (Latin and common names) along with the term ＂glutamate＂ in the following databases across all available years: PubMed, Scopus, and Google Scholar. This review emphasizes the importance of glutamate toxicity in NDD and summarizes individual plants and their active constituents with the mechanism of action against glutamate toxicity-mediated neuronal cell death that could be a promising resource for future NDD therapy. Taxonomy (classification by evise): Alzheimer's disease, Neurodegenerative diseases, Cell culture, Molecular Biology, Traditional herbal medicine, Oxidative stress, Glutamate neurotransmitter.
主题分类 醫藥衛生 > 中醫藥學
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