Current development in integrative therapy of traditional Chinese medicine for cancer treatment: A mini-review

10.1016/j.jtcme.2019.07.001

Po-Hsuan Su；Chen-Jei Tai

Traditional Chinese medicine (TCM) ； Cancer treatment ； Aqueous extract of Solanum nigrum (AESN) ； Autophagic pathway ； Hematotoxicity ； Hepatotoxicity ； Paronychia

Journal of Traditional and Complementary Medicine

10卷5期（2020 / 09 / 01）

429 - 433

英文

Cancer is a major public health problem worldwide, and there has been a sustained rise in its incidence in both developing and developed countries. Although there are currently numerous effective therapeutic options for cancer, they sometimes exhibit resistance and obvious side effects. Traditional Chinese medicine (TCM) currently plays a major role in cancer therapy by downregulating the growth of cancer cells through various pathways and by relieving side effects. Studies in cultured human malignant cell lines have demonstrated that Solanum nigrum can control cancer cell proliferation and cancer progression by inducing autophagic and apoptotic cell death. Case-control studies have indicated that TCM can relieve the side effects of cancer therapy. This review provides brief insights into the anticancer effects of TCM, the side effects relieved by TCM, and the role of TCM doctors in cancer treatment.

1. Cancer; 2018. https://www.who.int/en/news-room/fact-sheets/detail/cancer.Accessed September 12, 2018.
2. An, L,Tang, JT,Liu, XM,Gao, NN(2006).Review about mechanisms of anti-cancer of Solanum nigrum.Zhongguo Zhong yao za zhi,31(15),1225-1226+1260.
3. Chien, TJ,Liu, CY,Lu, RH,Kuo, CW,Lin, YC,Hsu, CH(2016).Therapeutic efficacy of Traditional Chinese medicine, "Kuan-Sin-Yin", in patients undergoing chemotherapy for advanced colon cancer - a controlled trial.Complement Ther Med,29,204-212.
4. Huang, HC,Syu, KY,Lin, JK(2010).Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells.J Agric Food Chem,58(15),8699-8708.
5. Huang, SM,Chien, LY,Tai, CJ,Chiou, JF,Chen, CS,Tai, CJ(2013).Effectiveness of 3-week intervention of Shi Quan Da Bu Tang for alleviating hematotoxicity among patients with breast carcinoma receiving chemotherapy.Integr Cancer Ther,12(2),136-144.
6. Jain, R,Sharma, A,Gupta, S,Sarethy, IP,Gabrani, R(2011).Solanum nigrum: current perspectives on therapeutic properties.Altern Med Rev : J Clin Ther,16(1),78-85.
7. Kumar, PJ,Clark, ML(2017).Kumar and Clark's Clinical Medicine.
8. Lai, YJ,Tai, CJ,Wang, CW(2016).Anti-cancer activity of Solanum nigrum (AESN) through suppression of mitochondrial function and epithelial-mesenchymal transition (EMT) in breast cancer cells.Molecules,21(5)
9. Liu, CY,Ko, PH,Yen, HR(2016).The Chinese medicine Kuan-Sin-Yin improves liver function in patients with chronic hepatitis C: a randomised and placebo-controlled trial.Complement Ther Med,27,114-122.
10. Liu, ML,Chien, LY,Tai, CJ,Lin, KC,Tai, CJ(2011).Effectiveness of traditional Chinese medicine for liver protection and chemotherapy completion among cancer patients.Evid Based Complement Altern Med : eCAM,2011,291843.
11. Lyman, GH,Abella, E,Pettengell, R(2014).Risk factors for febrile neutropenia among patients with cancer receiving chemotherapy: a systematic review.Crit Rev Oncol-Hematol,90(3),190-199.
12. Panahi, Y,Saadat, A,Sahebkar, A,Hashemian, F,Taghikhani, M,Abolhasani, E(2012).Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial.Integr Cancer Ther,11(3),204-211.
13. Riesco-Martinez, M,Parra, K,Saluja, R,Francia, G,Emmenegger, U(2017).Resistance to metronomic chemotherapy and ways to overcome it.Cancer Lett,400,311-318.
14. Sequist, LV,Yang, JC(2013).Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.J Clin Oncol : Off J Am Soc Clin Oncol,31(27),3327-3334.
15. Shokrzadeh, M,Azadbakht, M,Ahangar, N,Hashemi, A,Saeedi Saravi, SS(2010).Cytotoxicity of hydro-alcoholic extracts of Cucurbitapepo and Solanum nigrum on HepG2 and CT26 cancer cell lines.Phcog Mag,6(23),176-179.
16. Tai, CJ,Wang, CK,Chang, YJ,Lin, CS,Tai, CJ(2012).Aqueous extract of Solanum nigrum leaf activates autophagic cell death and enhances docetaxel-induced cytotoxicity in human endometrial carcinoma cells.Evid Based Complement Altern Med,2012,859185.
17. Tai, CJ,Wang, CK,Tai, CJ(2013).Aqueous extract of Solanum nigrum leaves induces autophagy and enhances cytotoxicity of cisplatin, doxorubicin, docetaxel, and 5-fluorouracil in human colorectal carcinoma cells.Evid Based Complement Altern Med,2013,514719.
18. Wang, CK,Lin, YF,Tai, CJ(2015).Integrated treatment of aqueous extract of Solanum nigrum-potentiated cisplatin- and doxorubicin-induced cytotoxicity in human hepatocellular carcinoma cells.Evid Based Complement Altern Med,2015,675270.
19. Wang, CW,Chen, CL,Wang, CK(2015).Cisplatin-, doxorubicin-, and docetaxel-induced cell death promoted by the aqueous extract of Solanum nigrum in human ovarian carcinoma cells.Integr Cancer Ther,14(6),546-555.
20. Wu, Z,Zhu, Q,Yin, Y(2018).Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.Canc Med,7(4),1546-1559.
21. Yang, PY,Tai, CJ(2017).Chinese medicine treatment for afatinib-induced paronychia.Case Rep Oncol Med,2017,7327359.