The role of nutraceuticals as a complementary therapy against various neurodegenerative diseases: A mini-review

10.1016/j.jtcme.2020.03.008

Hui-Fang Chiu；Kamesh Venkatakrishnan；Chin-Kun Wang

Nutraceutical ； Neurodegenerative diseases ； Clinical trial ； Neuroprotective agents

Journal of Traditional and Complementary Medicine

10卷5期（2020 / 09 / 01）

434 - 439

英文

In recent times, many scientists have given great attention to nutraceuticals (complementary medicine) as it widely used for promoting health status. In particular for the prevention and treatment of various neurological diseases or disorders without or less adverse effects. The current mini-review was intended to compile all popular (major) nutraceuticals against various neurodegenerative diseases (NDDs) including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) with special reference to clinical trials. Preliminary reviews indicated that nutraceuticals like curcumin, resveratrol, Epigallocatechin-3-gallate (EGCG), Coenzyme Q10, ω-3 FA (DHA/EPA/ALA), showed better neuroprotective activity against various NDDs in human setting (clinical trial). Hence this contribution will focus only on those popular nutraceuticals with proposed brief mechanisms (antioxidant, anti-inflammatory, mitochondrial homeostasis, autophagy regulation, promote neurogenesis) and its recommendation. This mini-review would aid common people to choose better nutraceuticals to combat various NDDs along with standard neuroprotective agents and modified lifestyle pattern.

1. Adefegha, SA(2018).Functional foods and nutraceuticals as dietary intervention in chronic diseases; novel perspectives for health promotion and disease prevention.J Diet Suppl,15,977-1009.
2. Agnihotri, A,Aruoma, OI.(2020).Alzheimer’s disease and Parkinson’s disease: a nutritional toxicology perspective of the impact of oxidative stress, mitochondrial dysfunction, nutrigenomics, and environmental chemicals.J Am Coll Nutr,39,16-27.
3. Avallone, R,Vitale, G,Bertolotti, M(2019).Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials.Int J Mol Sci.,20,4256.
4. Balakrishnan, P,Lee, BJ,Oh, DH(2009).Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems.Int J Pharm,374,66-72.
5. Baum, L,Lam, CW,Cheung, SK(2008).Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer’s disease.J Clin Psychopharmacol,28,110-113.
6. Belchior, T,Paschoal, VA,Magdalon, J(2015).Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions.Mol Nutr Food Res,59,957-967.
7. Berman, AY,Motechin, RA,Wiesenfeld, MY,Holz, MK(2017).The therapeutic potential of resveratrol: a review of clinical trials.NPJ Precision Oncol,1,1-9.
8. Chakrawarti, L,Agrawal, R,Dang, S,Gupta, S,Gabrani, R(2016).Therapeutic effects of EGCG: a patent review.Expert Opin Ther Pat,26,907-916.
9. Cheng, KK,Chan, PS,Fan, S(2015).Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer’s disease mice using magnetic resonance imaging (MRI).Biomaterials,44,155-172.
10. Chiu, HF,Lin, TY,Shen, YC,Venkatakrishnan, K,Wang, CK(2016).Improvement of green tea polyphenol with milk on skin with respect to antioxidation in healthy adults: a double-blind placebo-controlled randomized crossover clinical trial.Food Funct,7,893-901.
11. Chiu, HF,Shen, YC,Venkatakrishnan, K,Wang, CK(2018).Popular functional foods and nutraceuticals with lipid lowering activity and in relation to cardiovascular disease, dyslipidemia, and related complications: an overview.J Food Bioactives,2,16-27.
12. Cobley, JN,Fiorello, ML,Bailey, DM(2018).13 reasons why the brain is susceptible to oxidative stress.Redox biol,15,490-503.
13. Coimbra, M,Isacchi, B,van Bloois, L(2011).Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.Int J Pharm,416(2),433-442.
14. da Silva, TM,Munhoz, RP,Alvarez, C(2008).Depression in Parkinson’s disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fattyacid supplementation.J Affect Disord,111,351-359.
15. Dadhania, PV,Trivedi, PP,Vikram, A,Nand, Tripathi, D(2016).Nutraceuticals against neurodegeneration: a mechanistic insight.Curr Neuropharmacol,14,627-640.
16. Daliu, P,Santini, A,Novellino, E(2018).A decade of nutraceutical patents: where are we now in 2018?.Expert Opin Ther Pat,28,875-882.
17. Del Rio, D,Calani, L,Cordero, C,Salvatore, S,Pellegrini, N,Brighenti, F(2010).Bioavailability and catabolism of green tea flavan-3-ols in humans.Nutrition,26,1110-1116.
18. Dong, Y,Xu, M,Kalueff, AV,Song, C(2018).Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1b administration.Eur J Nutr,57,1781-1791.
19. Eckert, GP,Lipka, U,Muller, WE(2013).Omega-3 fatty acids in neurodegenerative diseases: focus on mitochondria.Prostaglandins Leukot Essent Fatty Acids.,88,105-114.
20. Evans, H,Howe, P,Wong, R(2017).Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women; a 14-week randomised placebo-controlled intervention trial.Nutrition,9,27.
21. Farkhondeh, T,Yazdi, HS,Samarghandian, S(2019).The protective effects of green tea catechins in the management of neurodegenerative diseases: a review.Curr Drug Discov Technol,16,57-65.
22. Gomes, BA,Silva, JP,Romeiro, CF(2018).Neuroprotective mechanisms of resveratrol in Alzheimer’s disease: role of SIRT1.Oxid Med Cell Longev,2018
23. Gutierrez-Mariscal, FM,Yubero-Serrano, EM,Villalba, JM,Lopez-Miranda, J(2019).Coenzyme Q10: from bench to clinic in aging diseases, a translational review.Crit Rev Food Sci Nutr,59,2240-2257.
24. Hatami, M,Abdolahi, M,Soveyd, N,Djalali, M,Togha, M,Honarvar, NM(2019).Molecular mechanisms of curcumin in neuroinflammatory disorders: a mini review of current evidences.Endocr Metab Immune Disord - Drug Targets,19,247-258.
25. Hopperton, KE,Trepanier, MO,Giuliano, V,Bazinet, RP(2016).Brain omega-3 poly-unsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice.J Neuroinflammation,13,257.
26. Hui, Y,Chengyong, T,Cheng, L,Haixia, H,Yuanda, Z,Weihua, Y(2018).Resveratrol attenuates the cytotoxicity induced by amyloid-β 1-42 in PC12 cells by upregulating heme oxygenase-1 via the PI3K/Akt/Nrf2 pathway.Neurochem Res,43,297-305.
27. Jing, L,He, MT,Chang, Y(2015).Coenzyme Q10 protects astrocytes from ROSinduced damage through inhibition of mitochondria-mediated cell death pathway.Int J Biol Sci,11,59.
28. Kakutani, S,Watanabe, H,Murayama, N(2019).Green tea intake and risks for dementia, Alzheimer’s disease, mild cognitive impairment, and cognitive impairment: a systematic review.Nutrition,11,1165.
29. Kelsey, NA,Wilkins, HM,Linseman, DA(2010).Nutraceutical antioxidants as novel neuroprotective agents.Molecules,15,7792-7814.
30. Kondo, K,Morino, K,Nishio, Y(2014).A fish-based diet intervention improves endothelial function in postmenopausal women with type 2 diabetes mellitus: a randomized crossover trial.Metabolism,63,930-940.
31. Kulkarni, SK,Bhutani, MK,Bishnoi, M(2008).Antidepressant activity of curcumin: involvement of serotonin and dopamine system.Psychopharmacol,201(3),435.
32. Lange, KW,Nakamura, Y,Gosslau, AM,Li, S(2019).Are there serious adverse effects of omega-3 polyunsaturated fatty acid supplements?.J Food Bioactives,7,1-7.
33. Lee, LK,Shahar, S,Chin, AV,Yusoff, NA(2013).Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial.Psychopharmacol,225,605-612.
34. Limanaqi, F,Biagioni, F,Busceti, CL(2019).Phytochemicals bridging autophagy induction and alpha-synuclein degradation in parkinsonism.Int J Mol Sci.,20,3274.
35. Lopresti, AL,Maes, M,Maker, GL,Hood, SD,Drummond, PD(2014).Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study.J Affect Disord,167,368-375.
36. Maes, M,Kallaur, AP,Lopes, J,Oliveira, SR,Ramon, D,Reiche, EM(2016).Immune-inflammatory and oxidative and nitrosative stress (IO & NS) pathways in depression and multiple sclerosis (MS): shared IO & NS pathways but less hyper-acute neuro-inflammation explain the increased incidence of depression in MS.Neurol Psychiatr Brain Res,1,16-17.
37. Mancini, E,Beglinger, C,Drewe, J,Zanchi, D,Lang, UE,Borgwardt, S(2017).Green tea effects on cognition, mood and human brain function: a systematic review.Phytomedicine,34,26-37.
38. Mantzorou, M,Pavlidou, E,Vasios, G,Tsagalioti, E,Giaginis, C(2018).Effects of curcumin consumption on human chronic diseases: a narrative review of the most recent clinical data.Phytother Res,32,957-975.
39. Marx, W,Kelly, JT,Marshall, S(2018).Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials.Nutr Rev,76,432-443.
40. Mehrpooya, M,Yasrebifar, F,Haghighi, M,Mohammadi, Y,Jahangard, L(2018).Evaluating the effect of coenzyme Q10 augmentation on treatment of bipolar depression: a double-blind controlled clinical trial.J Clin Psychopharmacol,38,460-466.
41. Mereles, D,Hunstein, W(2011).Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?.Int J Mol Sci,12,5592-5603.
42. Morris, MC,Evans, DA,Bienias, JL(2003).Consumption of fish and n-3 fatty acids and risk of incident Alzheimer’s disease.Arch Neurol,60,940-946.
43. Moussa, C,Hebron, M,Huang, X(2017).Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease.J Neuroinflammation,14,1.
44. Noguchi-Shinohara, M,Yuki, S,Dohmoto, C(2014).Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.PloS One,9,e96013.
45. Osher, Y,Bersudsky, Y,Belmaker, RH(2005).Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study.J Clin Psychiatr,66,726-729.
46. Pandareesh, MD,Kandikattu, HK,Razack, S(2018).Nutrition and nutraceuticals in neuroinflammatory and brain metabolic stress: implications for neurodegenerative disorders.CNS Neurol Disord - Drug Targets,17,680-688.
47. Pasinetti, GM,Wang, J,Ho, L,Zhao, W,Dubner, L(2015).Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment.Biochim Biophys Acta (BBA) - Mol Basis Dis,1852,1202-1208.
48. Perrone, L,Squillaro, T,Napolitano, F,Terracciano, C,Sampaolo, S,Melone, MA(2019).The autophagy signaling pathway: a potential multifunctional therapeutic target of curcumin in neurological and neuromuscular diseases.Nutrition,11,1881.
49. Pervin, M,Unno, K,Ohishi, T,Tanabe, H,Miyoshi, N,Nakamura, Y(2018).Beneficial effects of green tea catechins on neurodegenerative diseases.Molecules,23,1297.
50. Pourhanifeh, MH,Shafabakhsh, R,Reiter, RJ,Asemi, Z(2019).The effect of resveratrol on neurodegenerative disorders: possible protective actions against autophagy, apoptosis, inflammation and oxidative stress.Curr Pharmaceut Des.,25,2178-2191.
51. Prasanth, MI,Sivamaruthi, BS,Chaiyasut, C,Tencomnao, T(2019).A review of the role of green tea (Camellia sinensis) in antiphotoaging, stress resistance, neuroprotection, and autophagy.Nutrients,11,474.
52. Qiu, C,De Ronchi, D,Fratiglioni, L(2007).The epidemiology of the dementias: an update.Curr Opin Psychiatr,20,380-385.
53. Rezai-Zadeh, K,Shytle, D,Sun, N(2005).Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer’s transgenic mice.J Neurosci,25,8807-8814.
54. Saini, RK,Keum, YS(2018).Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance-a review.Life Sci.,203,255-267.
55. Sanmukhani, J,Satodia, V,Trivedi, J(2014).Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial.Phytother Res,28,579-585.
56. Santini, A,Novellino, E(2018).Nutraceuticals: shedding light on the grey area between pharmaceuticals and food.Expet Rev Clin Pharmacol,11,545-547.
57. Scholey, A,Downey, LA,Ciorciari, J(2012).Acute neurocognitive effects of epigallocatechin gallate (EGCG).Appetite,58,767-770.
58. Shukla, S,Dubey, KK(2018).CoQ10 a super-vitamin: review on application and biosynthesis.3 Biotech,8,249.
59. Shults, CW,Haas, RH,Passov, D,Beal, MF(1997).Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.Ann Neurol: Off J Am Neurol Assoc Child Neurol Soc,42,261-264.
60. Spindler, M,Beal, MF,Henchcliffe, C(2009).Coenzyme Q10 effects in neurodegenerative disease.Neuropsychiatric Dis Treat,5,597.
61. Teter, B,Morihara, T,Lim, GP(2019).Curcumin restores innate immune Alzheimer’s disease risk gene expression to ameliorate Alzheimer’s pathogenesis.Neurobiol Dis.,127,432-448.
62. Tiwari, SK,Agarwal, S,Seth, B(2014).Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer’s disease model via canonical Wnt/b-catenin pathway.ACS Nano,8,76-103.
63. Tomata, Y,Kakizaki, M,Nakaya, N(2012).Green tea consumption and the risk of incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 Study.Am J Clin Nutr,95,732-739.
64. Turner, RS,Thomas, RG,Craft, S(2015).A randomized, double-blind, placebocontrolled trial of resveratrol for Alzheimer’s disease.Neurol,85,1383-1391.
65. Venkatakrishnan, K,Chiu, HF,Cheng, JC(2018).Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechinenriched green and oolong tea in a double-blind clinical trial.Food Funct,9,1205-1213.
66. Venkatakrishnan, K,Chiu, HF,Wang, CK(2019).Popular functional foods and herbs for the management of type-2-diabetes mellitus: a comprehensive review with special reference to clinical trials and its proposed mechanism.J Funct Foods.,57,425-438.
67. Venkatakrishnan, K,Chiu, HF,Wang, CK(2019).Extensive review of popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials.Food Funct,10,2313-2329.
68. Vidoni, C,Secomandi, E,Castiglioni, A,Melone, MA,Isidoro, C(2018).Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation.Neurochem Int,117,174-187.
69. Voulgaropoulou, SD,van Amelsvoort, TA,Prickaerts, J,Vingerhoets, C(2019).The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: a systematic review of pre-clinical and clinical studies.Brain Res,1725,146476.
70. Wimo, A,Jönsson, L,Bond, J,Prince, M,Winblad, B,International, AD(2013).The worldwide economic impact of dementia 2010.Alzheimer Dement,9,1-10.
71. Witte, AV,Kerti, L,Margulies, DS,Flöel, A(2014).Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.J Neurosci,34,7862-7870.
72. Wu, S,Ding, Y,Wu, F,Li, R,Hou, J,Mao, P(2015).Omega-3 fatty acids intake and risks of dementia and Alzheimer’s disease: a meta-analysis.Neurosci Biobehav Rev,48,1-9.
73. Wu, Y,Li, X,Zhu, JX(2011).Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease.Neurosignals,19,163-174.
74. Xing, L,Zhang, H,Qi, R,Tsao, R,Mine, Y(2019).Recent advances in the understanding of the health benefits and molecular mechanisms associated with green tea polyphenols.J Agric Food Chem,67,1029-1043.
75. Yang, X,Zhang, Y,Xu, H(2016).Neuroprotection of coenzyme Q10 in neurodegenerative diseases.Curr Top Med Chem,16,858-866.
76. Yoritaka, A,Kawajiri, S,Yamamoto, Y(2015).Randomized, double-blind, placebocontrolled pilot trial of reduced coenzyme Q10 for Parkinson’s disease.Park Relat Disord,21,911-916.
77. Zhu, ZG,Sun, MX,Zhang, WL,Wang, WW,Jin, YM,Xie, CL(2017).The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials.Neurol Sci.,38,215-224.