题名

Ameliorative effect of virgin olive oil against nephrotoxicity following sub-chronic administration of ethephon in male rats

DOI

10.1016/j.jtcme.2019.08.005

作者

Tahmineh Mokhtari；Hosam-Eldin Hussein Osman；Ayman El-Meghawry El-Kenawy；Nasrin Dashti

关键词

Virgin olive oil ； Ethephon ； Nephrotoxicity ； Kidney ； Histopathology ； Rat

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

10卷5期（2020 / 09 / 01）

页次

487 - 495

内容语文

英文
中文摘要

Background: Ethephon (EP) is the most famous plant growth regulator with different adverse effects on kidney function. Virgin Olive Oil (VOO) is considered as a natural source of antioxidant with beneficial effects. Thus, this study was conducted to investigate the effects of VOO on nephrotoxicity induced by EP in rats. Methods and materials: In this study, 80 male rats (weighing 200-250 g) were divided into four groups including I: control group received normal saline as vehicle, II: received VOO, III: received EP (150 mg/kg/ day) for 2 months, IV: received EP (150 mg/kg/day for 2 months, after 2-month pretreatment with VOO. VOO (2 mL/kg/day) and vehicle were administered by gastric gavage for 2 months. At the end, the animals were sacrificed, and their blood and kidneys were used for examinations. Isolated kidneys were used for histopathological and oxidative stress studies. Results: Significant increases were recorded in blood (neutrophils, monocytes) and urinary parameters as well as malondialdehyde (MDA) content in the group III compared to groups II and I (P＜0.05). Antioxidant enzymes significantly declined and histopathological alterations increased in the group III. In the group IV, significant decreases were recorded in blood and urinary parameters, MDA, and histopathological alterations and a significant increase were found in antioxidant enzymes compared to group III (P＜0.05). Conclusions: Findings of the present study demonstrated protective effects of VOO in prevention of kidneys against EP -induced toxicity in albino rats.
主题分类 醫藥衛生 > 中醫藥學
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