题名

Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection

DOI

10.1016/j.jtcme.2020.12.001

作者

Anchalee Prasansuklab；Atsadang Theerasri；Panthakarn Rangsinth；Chanin Sillapachaiyaporn；Siriporn Chuchawankul；Tewin Tencomnao

关键词

SARS-CoV-2 ； 2019-nCoV ； Anti-viral ； Therapeutic strategies ； Natural compound ； Herbal medicine ； Plant ； Mushroom

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

11卷2期（2021 / 03 / 01）

页次

144 - 157

内容语文

英文
中文摘要

Background and aim: The novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now become a worldwide pandemic bringing over 71 million confirmed cases, while the specific drugs and vaccines approved for this disease are still limited regarding their effectiveness and adverse events. Since virus incidences are still on rise, infectivity and mortality may also rise in the near future, natural products are highly considered to be valuable sources for the discovery of new antiviral drugs against SARS-CoV-2. This present review aims to comprehensively summarize the up-to-date scientific literatures on biological activities of plant- and mushroom-derived compounds relevant to mechanistic targets involved in SARS-CoV-2 infection and inflammatory-associated pathogenesis, including viral entry, replication and release, and the renin-angiotensin-aldosterone system (RAAS). Experimental procedure: Data were retrieved from a literature search available on PubMed, Scopus and Google Scholar databases and collected until the end of May 2020. The findings from in vitro cell and non-cell based studies were considered, while the results of in silico studies were excluded. Results and conclusion: Based on the previous findings in SARS-CoV studies, except in silico molecular docking analysis, herein, we provide a total of 150 natural compounds as potential candidates for development of new anti-COVID-19 drugs with higher efficacy and lower toxicity than the existing therapeutic agents. Several natural compounds have showed their promising actions on multiple therapeutic targets, which should be further explored. Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.
主题分类 醫藥衛生 > 中醫藥學
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被引用次数
  1. Lee-Yan Sheen,Ciro Isidoro,Ashley Chiung-Fang Chang(2022).Natural products as a source of novel drugs for treating SARS-CoV2 infection.Journal of Traditional and Complementary Medicine,12(1),1-5.
  2. Sameh S. Elhady,Khaled M. Darwish,Ahmed Ashour,Ahmed A. Zaki,Ahmed A. Al-Karmalawy(2022).Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies.Journal of Traditional and Complementary Medicine,12(1),16-34.
  3. Tewin Tencomnao,Sunita Nilkhet,Siriporn Chuchawankul,Panthakarn Rangsinth,Chanin Sillapachaiyaporn,Alison T. Ung(2021).Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach.Journal of Traditional and Complementary Medicine,11(2),158-172.
  4. Vijay Kumar Bhardwaj,Sanjay Kumar,Rituraj Purohit,Rahul Singh,Jatin Sharma(2022).In-silico evaluation of bioactive compounds from tea as potential SARS-CoV-2 nonstructural protein 16 inhibitors.Journal of Traditional and Complementary Medicine,12(1),35-43.
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