题名

Inonotus obliquus - from folk medicine to clinical use

DOI

10.1016/j.jtcme.2020.08.003

作者

Konrad A. Szychowski；Bartosz Skóra；Tadeusz Pomianek；Jan Gmiński

关键词

Inonotus obliquus ； Anti-Cancer ； Anti-inflammation ； Mushroom ； Anti-virus

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

11卷4期（2021 / 07 / 01）

页次

293 - 302

内容语文

英文
中文摘要

The Inonotus obliquus (I. obliquus) mushroom was traditionally used to treat various gastrointestinal diseases. For many years, mounting evidence has indicated the potential of I. obliquus extracts for treatment of viral and parasitic infections. Furthermore, substances from I. obiquus have been shown to stimulate the immune system. The most promising finding was the demonstration that I. obliquus has hypoglycemic and insulin sensitivity potential. This review summarizes the therapeutic potential of I. obliquus extracts in counteracting the progression of cancers and diabetes mellitus as well as their antiviral and antiparasitic activities and antioxidant role. As shown by literature data, various authors have tried to determine the molecular mechanism of action of I. obliquus extracts. Two mechanisms of action of I. obliquus extracts are currently emerging. The first is associated with the broad-sense impact on antioxidant enzymes and the level of reactive oxygen species (ROS). The other is related to peroxisome proliferator-activated receptor gamma (PPARγ) effects. This receptor may be a key factor in the anti-inflammatory, antioxidant, and anti-cancer activity of I. obliquus extracts. It can be concluded that I. obliquus fits the definition of functional food and has a potentially positive effect on health beyond basic nutrition; however, studies that meet the evidence-based medicine (EBM) criteria are needed.
主题分类 醫藥衛生 > 中醫藥學
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