题名

Therapeutic potential of active components of saffron in post-surgical adhesion band formation

DOI

10.1016/j.jtcme.2021.01.002

作者

Mohammad-Hassan Arjmand;Milad Hashemzehi;Atena Soleimani;Fereshteh Asgharzadeh;Amir Avan;Saeedeh Mehraban;Maryam Fakhraei;Gordon A. Ferns;Mikhail Ryzhikov;Masoumeh Gharib;Roshanak Salari;Sayyed Hadi Sayyed Hoseinian;Mohammad Reza Parizadeh;Majid Khazaei;Seyed Mahdi Hassanian

关键词

Saffron ; Crocin ; Crocetin ; Post-surgical adhesion band formation ; Fibrosis ; Inflammation

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

11卷4期(2021 / 07 / 01)

页次

328 - 335

内容语文

英文

中文摘要

Background: Abdominal adhesions are common and often develop after abdominal surgery. There are currently no useful targeted pharmacotherapies for adhesive disease. Saffron and its active constituents, Crocin and Crocetin, are wildly used in traditional medicine for alleviating the severity of inflammatory or malignant disease. Purpose: The aim of this study was to investigate the therapeutic potential of the pharmacological active component of saffron in attenuating the formation of post-operative adhesion bands using different administration methods in a murine model. Material method: saffron extract (100 mg/kg), Crocin (100 mg/kg), and Crocetin (100 mg/kg) were administered intraperitoneally and by gavage in various groups of male Wistar rat post-surgery. Also three groups were first treated intra-peritoneally by saffron extract, Crocin, and Crocetin (100 mg/kg) for 10 days and then had surgery. At the end of the experiments, animals sacrificed for biological assessment. Result: A hydro-alcoholic extract of saffron and crocin but not crocetin potently reduced the adhesion band frequency in treatment and pre-treatment groups in the mice given intra-peritoneal (i.p) injections. Following the saffron or crocin administration, histological evaluation and quantitative analysis represented less inflammatory cell infiltration and less collagen composition, compared to control group. Moreover, the oxidative stress was significantly reduced in treatment groups. Conclusion: These findings suggest that a hydro-alcoholic extract of saffron or its active compound, crocin, is a potentially novel therapeutic strategy for the prevention of adhesions formation and might be used as beneficial anti-inflammatory or anti-fibrosis agents in clinical trials. Taxonomy: Abdominal surgeries/post-surgical adhesions.

主题分类 醫藥衛生 > 中醫藥學
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被引用次数
  1. (2024).Crocin elicits potent anti-inflammatory and fibrinolytic properties post tendon injury, A new molecule for adhesion therapy.Journal of Traditional and Complementary Medicine,14(6),687-696.