Effect of yoga on depression in hypothyroidism: A pilot study

10.1016/j.jtcme.2021.01.001

S. Rani；Satyapriya Maharana；Kashinath G. Metri；Hemant Bhargav；R. Nagaratna

Thyrotropin ； Health ； Complementary therapies ； Women ； Anxiety ； Body mass index

Journal of Traditional and Complementary Medicine

11卷4期（2021 / 07 / 01）

375 - 380

英文

Background: The prevalence of hypothyroidism among Indian women is 15.8%. Depression is frequently reported in hypothyroidism. Yoga is an effective intervention for depression. However, the influence of yoga on depression in patients with hypothyroidism has not been studied. Aim: The present study investigated the effect of a 3-month integrated yoga intervention (3-IY) on depression, lipid indices, and serum thyroid-stimulating hormone (sTSH) levels among female patients having hypothyroidism, and mild-to-moderate depression. Method: The present single-arm preepost design study was conducted in thirty-eight women (average age 34.2 ± 4.7 years). Participants received a 3-IY comprising asanas, pranayama, and relaxation techniques for 60 min daily (5 days a week). Depression, sTSH, lipid profile indices, Body Mass Index (BMI), fatigue, anxiety, and stress were assessed at baseline and after 12 weeks. Thyroid medication was kept constant during the study period. Data were analysed using R Studio software. Result: A significant (P ＜ 0.05) reduction in depression (58%), sTSH (37%), BMI (6%), fatigue (64%), anxiety (57%), lipid profile indices (HLD increased significanty), and stress (55%) levels was observed after 3 months, compared with the corresponding baseline levels. Conclusion: The 3-IY is useful for reducing depression, dyslipidemia, and sTSH in women with hypothyroidism and depression. Further studies with a larger sample size and a robust research design using objective variables must be conducted to strengthen the study findings.

1. Banerjee, S(2019).Study on yoga intervention along with diet on hypothyroidism associated with obesity among sedentary working women in West Bengal.International Journal of Yoga and Allied Sciences,1,2278-5159.
2. Cahn, BR,Goodman, MS,Peterson, CT,Maturi, R,Mills, PJ(2017).Yoga, meditation and mind-body health: increased BDNF, cortisol awakening response, and altered inflammatory marker expression after a 3-month yoga and meditation retreat.Front Hum Neurosci,11,315.
3. Ciloglu, F,Peker, I,Pehlivan, A(2005).Exercise intensity and its effects on thyroid hormones.Neuroendocrinol Lett,26(6),830-834.
4. Cramer, H,Lauche, R,Langhorst, J,Dobos, G(2013).Yoga for depression: a systematic review and meta-analysis.Depress Anxiety,30(11),1068-1083.
5. Cramer, H,Lauche, R,Langhorst, J,Dobos, G.(2013).Yoga for depression: a systematic review and meta-analysis.Depress Anxiety,30(11),1068-1083.
6. Demartini, B,Masu, A,Scarone, S,Pontiroli, AE,Gambini, O(2010).Prevalence of depression in patients affected by subclinical hypothyroidism.Panminerva Med.,52(4),277-282.
7. Deokar, PG,Nagdeote, AN,Lanje, MJ,Basutkar, DG(2016).Prevalence of thyroid disorders in a tertiary care center.International Journal of Current Research and Review,8(9),26.
8. Fountoulakis, KN,Iacovides, A,Grammaticos, P,St Kaprinis, G,Bech, P(2004).Thyroid function in clinical subtypes of major depression: an exploratory study.BMC Psychiatr,4(1),6.
9. Haggerty, JJ,Stern, RA,Mason, GA,Beckwith, J,Morey, CE,Prange, AJ(1993).Subclinical hypothyroidism: a modifiable risk factor for depression?.Am J Psychiatr,150(3),508-510.
10. Hak, AE,Pols, HA,Visser, TJ,Drexhage, HA,Hofman, A,Witteman, JC(2000).Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study.Ann Intern Med,132(4),270-278.
11. Halder, K,Chatterjee, A,Kain, TC,Pal, R,Tomer, OS,Saha, M(2012).Improvement in ventilatory function through yogic practices.Al Ameen J Med Sci.,5(2),197-202.
12. Henry, JD,Crawford, JR(2005).The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample.Br J Clin Psychol,44(2),227-239.
13. Lee, KA,Hicks, G,Nino-Murcia, G(1991).Validity and reliability of a scale to assess fatigue.Psychiatr Res,36(3),291-298.
14. Loh, HH,Lim, LL,Yee, A,Loh, HS(2019).Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis.BMC Psychiatr,19(1),12.
15. Michalsen, A,Grossman, P,Acil, A(2005).Rapid stress reduction and anxiolysis among distressed women as a consequence of a three-month intensive yoga program.Med Sci Mon Int Med J Exp Clin Res,11(12),CR555-CR561.
16. Mohammad, MY,Bushulaybi, NA,AlHumam, AS(2019).Prevalence of depression among hypothyroid patients attending the primary healthcare and endocrine clinics of King Fahad Hospital of the University (KFHU).J Fam Med Prim Care,8(8),2708.
17. Rack, SK,Makela, EH(2000).Hypothyroidism and depression: a therapeutic challenge.Ann Pharmacother,34(10),1142-1145.
18. Singh, K,Junnarkar, M,Sharma, S(2015).Anxiety, stress, depression, and psychosocial functioning of Indian adolescents.Indian J Psychiatr,57(4),367.
19. Spencer, CA,Takeuchi, M,Kazarosyan, M,MacKenzie, F,Beckett, GJ,Wilkinson, E(1995).Interlaboratory/intermethod differences in functional sensitivity of immune-metric assays of thyrotropin (TSH) and impact on reliability of measurement of subnormal concentrations of TSH.Clin Chem,41(3),367-374.
20. Spratt, KF(2009).Minimal clinically important difference based on clinical judgment and minimally detectable measurement difference: a rationale for the SF-36 Physical Function scale in the SPORT Intervertebral disc herniation cohort.Spine,34(16),1722.
21. Steptoe, A(2006).Depression and physical illness.
22. Streeter, CC,Gerbarg, PL,Saper, RB,Ciraulo, DA,Brown, RP(2012).Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder.Med Hypotheses,78(5),571-579.
23. Swami, G,Singh, S,Singh, KP,Gupta, M(2010).Effect of yoga on pulmonary function tests of hypothyroid patients.Indian J Physiol Pharmacol,54(1),51-56.
24. Talaei, A,Rafee, N,Rafei, F,Chehrei, A(2017).TSH cut off point based on depression in hypothyroid patients.BMC Psychiatr,17(1),327.
25. Tappy, L,Randin, JP,Schwed, P,Wertheimer, J,Lemarchand-Béraud, T(1987).Prevalence of thyroid disorders in psychogeriatric inpatients A possible relationship of hypothyroidism with neurotic depression but not with dementia.J Am Geriatr Soc,35(6),526-531.
26. Whybrow, PC,Prange, AJ, Jr,Treadway, CR(1969).Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement.Arch Gen Psychiatr,20(1),48-63.
27. Wolkowitz, OM,Rothschild, AJ(2003).Psychoneuroendocrinology: The Scientific Basis of Clinical Practice.Washington, DC, USA:American Psychiatric.
28. Woolery, A,Myers, H,Sternlieb, B,Zeltzer, L(2004).A yoga intervention for young adults with elevated symptoms of depression.Alternative Ther Health Med,10(2),60-1 63.