题名

Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway

DOI

10.1016/j.jtcme.2021.02.007

作者

Nurul Uyun Abdul Aziz；Samaila Musa Chiroma；Mohamad Aris Mohd Moklas；Mohd Ilham Adenan；Amin Ismail；Rusliza Basir；Razana Mohd Ali；Mohamad Taufik Hidayat Bin Baharuldin

关键词

Menhaden fish oil ； Postpartum depression ； NLRP3-Inflammasome ； Forced swimming test ； Prefrontal cortex ； Hippocampus

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

11卷5期（2021 / 09 / 01）

页次

419 - 426

内容语文

英文
中文摘要

Background and aim: Postpartum depression (PPD) is a familiar problem which is associated with about 10-20% of women after child delivery. Fish oil (FO) has a therapeutic potentials to many diseases including mood disorders. However, there is paucity of data on the effects of FO supplementation on PPD rat model. Hence, this study aimed at investigating the potentials of FO in ameliorating depressive-like behaviors in PPD rat by evaluating the involvement of NLRP3-inflammasome. Experimental procedure: Thirty six virgin adult female rats (n=6) were randomly divided into six groups; Group 1-3 were normal control (NC), Sham (SHAM) and ovariectomized group (OVX) respectively whereas group 4-6 were PPD rats forced-fed once daily with distilled water (PPD), fish oil (PPD+FO; 9 g/kg) and Fluoxetine (PPD + FLX; 15 mg/kg) respectively from postpartum day 1 and continued for 10 consecutive days. Rats behaviors were evaluated on postpartum day 10 through open field test (OFT) and forced swimming test (FST), followed by biochemical analysis of NLRP3 inflammasome proteins pathway in their brain and determination of neutrophil to lymphocyte ratio (NLR). Results: PPD-induced rats exhibited high immobility and low swimming time in FST with increased inflammatory status; NLR, IL-1β and NFкB/NLRP3/caspase-1 activity in their hippocampus. However, administration of FO or fluoxetine reversed the aforementioned abnormalities. Conclusion: In conclusion, 10 days supplementation with FO ameliorated the depressive-like behaviors in PPD rats by targeting the NFкB/NLRP3/caspase-1/IL-1β activity. This has shed light on the potential of NLRP3 as a therapeutic target in treatment of PPD in rats.
主题分类 醫藥衛生 > 中醫藥學
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