题名

Targeting autophagy with natural products to prevent SARS-CoV-2 infection

DOI

10.1016/j.jtcme.2021.10.003

作者

Chiara Vidoni；Andréa Fuzimoto；Alessandra Ferraresi；Ciro Isidoro

关键词

COVID-19 ； Virophagy ； Coronavirus ； Chloroquine ； Pandemic ； Phytotherapy ； Resveratrol

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

12卷1期（2022 / 01 / 01）

页次

55 - 68

内容语文

英文
中文摘要

Autophagy is a catabolic process that maintains internal homeostasis and energy balance through the lysosomal degradation of redundant or damaged cellular components. During virus infection, autophagy is triggered both in parenchymal and in immune cells with different finalistic objectives: in parenchymal cells, the goal is to destroy the virion particle while in macrophages and dendritic cells the goal is to expose virion-derived fragments for priming the lymphocytes and initiate the immune response. However, some viruses have developed a strategy to subvert the autophagy machinery to escape the destructive destiny and instead exploit it for virion assembly and exocytosis. Coronaviruses (like SARS-CoV-2) possess such ability. The autophagy process requires a set of proteins that constitute the core machinery and is controlled by several signaling pathways. Here, we report on natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy. The present study provides support to the use of such natural products as adjuvant therapeutics for the management of COVID-19 pandemic to prevent the virus infection and replication, and so mitigating the progression of the disease.
主题分类 醫藥衛生 > 中醫藥學
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被引用次数
  1. Lee-Yan Sheen,Ciro Isidoro,Ashley Chiung-Fang Chang(2022).Natural products as a source of novel drugs for treating SARS-CoV2 infection.Journal of Traditional and Complementary Medicine,12(1),1-5.
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