Prevention of post-surgical adhesion bands by local administration of frankincense n-hexane extract

10.1016/j.jtcme.2021.10.004

Fatemeh Jamshidi-adegani；Saeid Vakilian；Juhaina Al-kindi；Najeeb Ur Rehman；Laila Alkalbani；Mohammed Al-Broumi；Nasar Al-Wahaibi；Asem Shalaby；Jamal Al-Sabahi；Ahmed Al-Harrasi；Sulaiman Al-Hashmi

Boswellia sacra resin ； Frankincense n-hexane extract ； Intra-abdominal adhesion ； TGF-β1 ； TNF-α ； Anti-inflammation

Journal of Traditional and Complementary Medicine

12卷4期（2022 / 07 / 01）

367 - 374

英文

Background: and purpose: The formation of postoperative intra-abdominal adhesion band formation may lead to severe complications. This study aimed to evaluate the preventive effect of local administration of frankincense n-hexane extract (FHE) on the formation of postsurgical adhesion bands. Materials and methods: FHE was extracted from the resin of a Boswellia sacra tree and its components were identified by gas chromatography-mass spectrometry (GC-MS). In an animal model, the expression levels of TNF-α and TGF-β1 cytokines after application of FHE were assessed to check the inflammatory and fibrotic cues, respectively. Results: Following FHE compound analysis, in vivo experiments demonstrated that intraoperative local administration of FHE resulted in the prevention of adhesion band formation. The adhesion grades in the FHE-treated group were significantly lower than those in the negative control (NC) and the positive control (Interceed). The infiltration of inflammatory cells observed by histopathology revealed a significant anti-inflammatory potential of FHE. Furthermore, the gene expression results proved that significant suppression of TNF-α and TGF-β1 was responsible for its antiadhesion properties. Conclusions: The study reported the potential of FHE as an ointment for the prevention of adhesion bands.

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