Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential

10.1016/j.jtcme.2022.01.004

Wahyu Widowati；Sijani Prahastuti；Meilinah Hidayat；Stella Tinia Hasianna；Roro Wahyudianingsih；The Fransiska Eltania；Alya Mardhotillah Azizah；Jenifer Kiem Aviani；Mawar Subangkit；Rr Anisa Siwianti Handayani；Hanna Sari Widya Kusuma

Blood urea nitrogen ； Catalase ； Fibronectin ； Glycine max L. Merr. ； Nephrotoxicity

Journal of Traditional and Complementary Medicine

12卷4期（2022 / 07 / 01）

426 - 435

英文

Background and aim: Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean (Glycine max L. Merr.) has been reported contain high levels of phenolics and anthocyanins that has antioxidant activity. This study aims to determine the effect of ethanol extract of black soybean (EEBS) against cisplatin-induced nephrotoxicity in rats. Experimental procedure: Cisplatin-induced nephrotoxicity rats treated with EEBS and the blood samples taken on days 0, 9, and 18. The effects of EEBS was evaluated by determining Interferon-γ (IFN-γ), Caspase-3 (Casp-3), and Interleukin-1β (IL-1β) expression using immunohistochemistry (IHC), blood urea nitrogen (BUN), Uric Acid (UA) content and catalase (CAT) content in the blood plasma with colorimetric assay kit. Results and conclusion: Based on the results, EEBS treatment had successfully reduced pro-inflammatory cytokines IL-1βand IFN-γ, and improved physiological condition by lowering BUN and UA content while increasing CAT activity. No significant effect was found in Casp-3 expression. EEBS has potential to improve acute renal failure condition through inflammatory suppression and renal function improvement.

1. Ademiluyi, AO,Oboh, G,Agbebi, OJ(2013).Anthocyanin - rich red dye of Hibiscus sabdariffa calyx modulates cisplatin-induced nephrotoxicity and oxidative stress in rats.Int J Biomed Sci,9,243-248.
2. Ajith, TA,Usha, S,Nivitha, V(2007).Ascorbic acid and a-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study.Clin Chim Acta,375,82-86.
3. Akca, G,Eren, H,Tumkaya, L(2018).The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats.Biomed Pharmacother,100,575-582.
4. Al-Kuraishy, HM,Al-Gareeb, AI,Al-Naimi, MS(2019).Renoprotective effect of irbesartan in a rat model of gentamicin-induced nephrotoxicity: role of oxidative stress.J Lab Phys,11,200-205.
5. Astadi, IR,Astuti, M,Santoso, U(2009).In vitro antioxidant activity of anthocyanins of black soybean seed coat in human low density lipoprotein (LDL).Food Chem,112,659-663.
6. Basile, DP,Anderson, MD,Sutton, TA(2012).Pathophysiology of acute kidney injury.Compr Physiol,2,1303-1353.
7. Bobkova, I,Chebotareva, N,Kozlovskaya, L(2016).Edema in renal diseases-current view on pathogenesis.Nephrol @ Point Care,2,e49-e55.
8. Darband, SG,Sadighparvar, S,Yousefi, B(2020).Combination of exercise training and l-arginine reverses aging process through suppression of oxidative stress, inflammation, and apoptosis in the rat heart.Pflügers Arch - Eur J Physiol,472,169-178.
9. de Camargo, AC,Favero, BT,Morzelle, MC(2019).Is chickpea a potential substitute for soybean? Phenolic bioactive and potential health benefits.Int J Mol Sci,20,1-42.
10. Ekor, M,Emerole, GO,Farombi, EO(2010).Phenolic extract of soybean (Glycine max) attenuates cisplatin-induced nephrotoxicity in rats.Food Chem Toxicol,48,1005-1012.
11. Giordano, C,Karasik, O,King-Morris, K(2015).Uric acid as a marker of kidney disease: review of the current literature.Dis Markers,2015,1-7.
12. Gondokesumo, ME,Pradjianto, B,Sumitro, SB(2019).Xanthones analysis and antioxidant activity analysis (Applying ESR) of six different maturity levels of mangosteen rind extract (Garcinia mangostana Linn.).Phcog J,11,369-373.
13. Grabulosa, CC,Batista, MC,Cendoroglo, M(2014).Frequency of TGF-β and IFN-γ genotype as risk factors for acute kidney injury and death in intensive care unit patients.BioMed Res Int,2014,1-7.
14. He, L(2019).Dietary fermented soy extract and active lactic acid alleviate chronic kidney disease in mice via inhibition of inflammation and modulation of gut microbiota (FS15-07-19).CDN,3,nzz031.FS15.
15. Hidayat, M,Prahastuti, S,Fauziah, N(2016).Modulation of adipogenesis-related gene expression by ethanol extracts of Detam 1 soybean and jati belanda leaf in 3T3-L1 cells.Bangladesh J Pharmacol,11,697-702.
16. Humanes, B,Camano, S,Lara, JM(2017).Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection.Nephrol Dial Transplant,32,1645-1655.
17. Hung, Y-H,Huang, H-Y,Chou, C-C(2007).Mutagenic and antimutagenic effects of methanol extracts of unfermented and fermented black soybeans.Int J Food Microbiol,118,62-68.
18. Karan, D(2018).Inflammasomes: emerging central players in cancer immunology and immunotherapy.Front Immunol,9,1-8.
19. Karasawa, T,Steyger, PS(2015).An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.Toxicol Lett,237,219-227.
20. Kim, IS(2021).Current perspectives on the beneficial effects of soybean isoflavones and their metabolites for human.Antioxidants,10,1-54.
21. Li, W-F,Yang, K,Zhu, P(2017).Genistein ameliorates ischemia/reperfusion-induced renal injury in a SIRT1-dependent manner.Nutrients,9,1-21.
22. Liu, J,Wen, XY,Zhang, XQ(2015).Extraction, characterization and in vitro antioxidant activity of polysaccharides from black soybean.Int J Biol Macromol,72,1182-1190.
23. Lu, HY,Ning, XY,Chen, YQ(2018).Predictive value of serum creatinine, blood urea nitrogen, uric acid, and β2-microglobulin in the evaluation of acute kidney injury after orthotopic liver transplantation.Chin Med J,131,1059-1066.
24. Manohar, S,Leung, N(2018).Cisplatin nephrotoxicity: a review of the literature.J Nephrol,31,15-25.
25. Meng, H,Fu, G,Shen, J(2017).Ameliorative effect of daidzein on cisplastin-induced nephrotoxicity in mice via modulation of inflammation, oxidative stress, and cell death.Oxid Med Cell Longev,1-21.
26. Miller, RP,Tadagavadi, RK,Ramesh, G(2010).Mechanisms of cisplatin nephrotoxicity.Toxins,2,2490-2518.
27. Mishima, K,Baba, A,Matsuo, M(2006).Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity.Free Radic Biol Med,40,1564-1577.
28. Naqshbandi, A,Khan, W,Rizwan, S(2012).Studies on the protective effect of flaxseed oil on cisplatin-induced hepatotoxicity.Hum Exp Toxicol,31,364-375.
29. Niu, C,Ma, M,Han, X(2017).Hyperin protects against cisplatin-induced liver injury in mice.Acta Cir Bras,32,633-640.
30. Okazaki, Y,Iqbal, M,Kawakami, N(2010).A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.J Clin Biochem Nutr,47,198-207.
31. Ozkok, A,Edelstein, CL(2014).Pathophysiology of cisplatin-induced acute kidney injury.BioMed Res Int,2014,1-18.
32. Pang, M,Fang, Y,Chen, S(2017).Gypenosides inhibits xanthine oxidoreductase and ameliorates urate excretion in hyperuricemic rats induced by high cholesterol and high fat food (lipid emulsion).Med Sci Monit,23,1129-1140.
33. Phommalath, S,Teraishi, M,Yoshikawa, T(2014).Wide genetic variation in phenolic compound content of seed coats among black soybean cultivars.Breed Sci,64,409-415.
34. Prahastuti, S,Hidayat, M,Hasiana, ST(2020).The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants.Pharmaciana,10,77-88.
35. Ratliff, BB,Abdulmahdi, W,Pawar, R(2016).Oxidant mechanisms in renal injury and disease.Antioxidants Redox Signal,25,119-146.
36. Sahu, BD,Kumar, JM,Sistla, R(2015).Baicalein, a bioflavonoid, prevents cisplatin-induced acute kidney injury by up-regulating antioxidant defenses and down-regulating the MAPKs and NF-kB pathways.PLoS One,10,1-19.
37. Seki, M,Nakayama, M,Sakoh, T(2019).Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study.BMC Nephrol,20,1-10.
38. Sheu, F,Lai, H-H,Yen, G-C(2001).Suppression effect of soy isoflavones on Nitric Oxide prodGiuction in RAW 264.7 macrophages.Agric Food Chem,49,1767-1772.
39. Soliman, A,Desouky, S,Marzouk, M(2016).Origanum majorana attenuates nephrotoxicity of cisplatin anticancer drug through ameliorating oxidative stress.Nutrients,8,1-9.
40. Soliman, MM,Nassan, MA,Aldhahrani, A(2020).Molecular and histopathological study on the ameliorative impacts of Petroselinum crispum and Apium graveolens against experimental hyperuricemia.Sci Rep,10,1-11.
41. Suliman, FA,Khodeer, DM,Ibrahiem, A(2018).Renoprotective effect of the iso-flavonoid biochanin A against cisplatin induced acute kidney injury in mice: effect on inflammatory burden and p53 apoptosis.Int Immunopharm,61,8-19.
42. Sun, J,Wen, X,Liu, J(2018).Protective effect of an arabinogalactan from black soybean against carbon tetrachloride-induced acute liver injury in mice.Int J Biol Macromol,117,659-664.
43. Sung, MJ,Kim, DH,Jung, YJ(2008).Protects the kidney from cisplatin-induced injury.Kidney Int,27,1538-1547.
44. Takahashi, R,Ohmori, R,Kiyose, C(2005).Antioxidant activities of black and yellow soybeans against low density lipoprotein oxidation.J Agric Food Chem,53,4578-4582.
45. Vargas, F,Romecín, P,García-Guillen, AI(2018).Flavonoids in kidney health and disease.Front Physiol,9,1-12.
46. Widowati, W,Prahastuti, S,Ekayanti, NLW(2019).Anti-inflammation assay of black soybean extract and its compounds on lipopolysaccharide-induced RAW 264.7 cell.J Phys Conf Ser,1374,012052.
47. Wu, YL,Chen, JF,Jiang, LY(2021).The extract of Sonneratia apetala leaves and branches ameliorates hyperuricemia in mice by regulating renal uric acid transporters and suppressing the activation of the JAK/STAT signaling pathway.Front Pharmacol,12,1-14.
48. Yoo, KM,Al-Farsi, M,Lee, H(2010).Antiproliferative effects of cherry juice and wine in Chinese hamster lung fibroblast cells and their phenolic constituents and antioxidant activities.Food Chem,123,734-740.
49. Yousef, MI,Hussien, HM(2015).Cisplatin-induced renal toxicity via tumor necrosis factor-α, interleukin 6, tumor suppressor P53, DNA damage, xanthine oxidase, histological changes, oxidative stress and nitric oxide in rats: protective effect of ginseng.Food Chem Toxicol,78,17-25.
50. Yu, G,Liu, Q,Dong, X(2018).Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice.Cell Mol Biol Lett,23,1-12.
51. Zhou, R,Cai, W,Xu, B(2017).Phytochemical profiles of black and yellow soybeans as affected by roasting.Int J Food Prop,20,3179-3190.
52. Zhu, H,Cao, R(2012).The relationship between serum levels of uric acid and prognosis of infection in critically ill patients.World J Emerg Med,3,186-190.