题名

Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives

DOI

10.1016/j.jtcme.2022.03.001

作者

Anshula Mehra；Geetakshi Arora；Gaurav Sahni；Manmohit Kaur；Hasandeep Singh；Balbir Singh；Sarabjit Kaur

关键词

Autism ； Gut dysbiosis ； Gut-brain-axis ； Dietary intervention ； Probiotics and prebiotics ； Herbal remedies

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

13卷2期（2023 / 03 / 01）

页次

135 - 149

内容语文

英文
中文摘要

Autism is a complex neurodevelopmental disorder which disrupts communication, social and interactive skills followed by appearance of repetitive behavior. The underlying etiology remains incomprehensible but genetic and environmental factors play a key role. Accumulated evidence shows that alteration in level of gut microbes and their metabolites are not only linked to gastrointestinal problems but also to autism. So far the mix of microbes that is present in the gut affects human health in numerous ways through extensive bacterial-mammalian cometabolism and has a marked influence over health via gut-brain- microbial interactions. Healthy microbiota may even ease the symptoms of autism, as microbial balance influences brain development through the neuroendocrine, neuroimmune, and autonomic nervous systems. In this article, we focused on reviewing the correlation between gut microbiota and their metabolites on symptoms of autism by utilizing prebiotics, probiotics and herbal remedies to target gut microflora hence autism.
主题分类 醫藥衛生 > 中醫藥學
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