题名

Vitisin B, a resveratrol tetramer from Vitis thunbergii var. taiwaniana, ameliorates impaired glucose regulations in nicotinamide/streptozotocin-induced type 2 diabetic mice

DOI

10.1016/j.jtcme.2023.05.003

作者

Yuh-Hwa Liu；Yin-Shiou Lin；Yi-Yan Sie；Ching-Chiung Wang；Chi-I Chang；Wen-Chi Hou

关键词

Nutraceuticals ； Resveratrol tetramers of vitisin a ； Vitisin B and hopeaphenol ； Type 2 diabetes mellitus (T2DM) ； Vitis thunbergii var. taiwaniana (VTT)

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

13卷5期（2023 / 09 / 01）

页次

479 - 488

内容语文

英文
中文摘要

Background and aim: In Taiwan, Vitis thunbergii var. taiwaniana (VTT) is used in traditional medicine and as a local tea. VTT rich in resveratrol and resveratrol oligomers have been reported to exhibit anti-obesity and anti-hypertensive activities in animal models; however, no studies have investigated type 2 diabetes mellitus (T2DM) treatments. This study aimed to investigate the anti-T2DM effects of resveratrol tetramers isolated from the VTT in nicotinamide/streptozotocin (STZ)-induced Institute of Cancer Research (ICR) mice. Experimental procedure: The oral glucose tolerance test (OGTT) was used to imitate postprandial blood glucose (BG) regulations in mice by pre-treatment with VTT extracts, resveratrol tetramers of vitisin A, vitisin B, and hopeaphenol 30 min before glucose loads. Vitisin B (50 mg/kg) was administered to treat T2DM-ICR mice once daily for 28 days to investigate its hypoglycemic activity. Results and conclusion: Mice pre-treated with VTT-S-95EE, or vitisin B (100 mg/kg) 30-min before glucose loading showed significant reductions (P < 0.001) in the area under the curve at 120-min (BG-AUC_(0-120)) than those without pre-treatment with VTT-S-95 E E or vitisin B. Vitisin B-treated T2DM mice showed hypoglycemic activities via a reduction in plasma dipeptidyl peptidase (DPP)-IV activities to maintain insulin actions and differed significantly than those of untreated T2DM mice (P < 0.05), and also reduced BG-AUC_(0-120) and insulin-AUC_(0-120) in the OGTT. These in vivo results showed that VTT containing vitisin B would be beneficial for developing nutraceuticals and/or functional foods for glycemic control in patients with T2DM, which should be investigated further.
主题分类 醫藥衛生 > 中醫藥學
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