题名

Phytocannabinoids: Pharmacological effects, biomedical applications, and worldwide prospection

DOI

10.1016/j.jtcme.2023.08.006

作者

Ana L.G. de Brito Siqueira；Pedro V.V. Cremasco；Juliana O. Bahú；Aline Pioli da Silva；Lucas R. Melo de Andrade；Paula G.A. González；Sara Crivellin；Viktor O. Cárdenas Concha；Karolline Krambeck；Leandro Lodi；Patrícia Severino；Eliana B. Souto

关键词

Cannabidiol ； Cannabis Sativa L. ； Commercial products ； Market ； Trans-Delta-9-tetrahydrocannabinol

期刊名称

Journal of Traditional and Complementary Medicine

卷期/出版年月

13卷6期（2023 / 11 / 01）

页次

575 - 587

内容语文

英文
中文摘要

Scientific evidence exists about the association between neurological diseases (i.e., Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, depression, and memory loss) and oxidative damage. The increasing worldwide incidence of such diseases is attracting the attention of researchers to find palliative medications to reduce the symptoms and promote quality of life, in particular, in developing countries, e.g., South America and Africa. Among potential alternatives, extracts of Cannabis Sativa L. are suitable for people who have neurological disorders, spasticity, and pain, nausea, resulting from diseases such as cancer and arthritis. In this review, we discuss the latest developments in the use of Cannabis, its subtypes and constituents, extraction methods, and relevant pharmacological effects. Biomedical applications, marketed products, and prospects for the worldwide use of Cannabis Sativa L. extracts are also discussed, providing the bibliometric maps of scientific literature published in representative countries from South America (i.e., Brazil) and Africa (i.e., South Africa). A lack of evidence on the effectiveness and safety of Cannabis, besides the concerns about addiction and other adverse events, has led many countries to act with caution before changing Cannabis-related regulations. Recent findings are expected to increase the social acceptance of Cannabis, while new technologies seem to boost the global cannabis market because the benefits of (-)-trans-delta-9-tetrahydrocannabinol (△9-THC) and cannabidiol (CBD) use have been proven in several studies in addition to the potential to general new employment.
主题分类 醫藥衛生 > 中醫藥學
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