Comparative Efficacy of Single-Fraction versus Multi-Fraction Stereotactic Body Radiotherapy for Spinal Metastases: A Meta-Analysis

10.6913/mrhk.060310

Wenwen JIANG；Yuxi ZHOU；Chuncheung CHAN

stereotactic body radiotherapy ； spinal metastases ； local control ； overall survival ； meta-analysis

Medical Research

6卷3期（2024 / 09 / 30）

103 - 118

英文

Objective: This study compares the efficacy of stereotactic body radiotherapy (SBRT) in patients with spinal metastases, focusing on single-fraction (SF-SBRT) versus multifraction (MF-SBRT) regimens. Methods: A literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase. Data analysis was performed using Engauge Digitizer, RevMan, and STATA software. Results: Fifteen studies were analyzed. SF-SBRT had a higher incidence of local failure but a lower rate of vertebral compression fractures (VCFs) compared to MF-SBRT. No significant differences were found in overall survival rates. The 1-year and 2-year local control rates for SBRT were 87% and 80%, with overall survival rates at 63% and 47%. Conclusions: SF-SBRT offers convenience and rapid relief, while MF-SBRT may provide better long-term control. Regimen selection should be based on the patient's clinical situation and preferences to optimize outcomes.