胸部低劑量CT在澳門肺癌高危人群篩查中的前瞻性研究

Prospective study of low-dose chest CT in screening high-risk population of lung cancer in macao

張振榮(CHEUNG Chun Wun)；張曉戰(ZHANG Xiao Zhan)；程鯤(CHENG Kun)；楊貞勇(YANG Zhen Yong)；朱偉國(ZHU Wei Guo)；林肇聰(LIN Zhao Cong)；曹亞兵(CAO Ya Bing)；李牧(LI Mu)

肺癌篩查 ； 肺部結節 ； 低劑量CT ； Lung cancer screening ； lung nodule ； Low-Dose Chest CT

鏡湖醫學

21卷1期（2021 / 06 / 01）

12 - 16+77

繁體中文;英文

目的：採用胸部低劑量CT（LDCT）對比肺癌高危人群與非高危人群中的肺癌發病情況，為制定符合澳門人群的肺癌篩查標準提供參考。方法：通過宣傳招募澳門無症狀肺癌高危人士，行胸部LDCT檢查，並與同期在本院健康中心行胸部LDCT檢查的非高危健康檢查者作為對照進行對比，分析肺癌、肺部結節檢出率等。結果：兩組肺癌總檢出率2.61%（95% CI：1.26%～3.95%），全為男性，肺腺癌佔71.42%。高危組檢出10例肺癌，6例為腺癌，檢出率3.19%（95%CI：1.24%～5.14%）；對照組檢出4例，全為腺癌，檢出率1.79%（95% CI：0.05%～3.52%），兩組檢出率無統計學差異。肺結節檢出率高危組73.20%，高於對照組64.29%（χ^2 =5.02, P <0.05）。結論：肺結節檢出率高危人群高於非高危人群，肺癌檢出率高危人群並不高於非高危人群。澳門男性肺癌以腺癌為主，在澳門進行肺癌篩查應重視致肺腺癌高危因素。

Objective: To compare the detection rate of lung cancer with low-dose chest CT (LDCT) between populations at a high-risk factors for lung cancer and that who without any risk factors. The study can provide reference for the development of lung cancer screening criteria in Macau. Methods: LDCT lung cancer screening were implemented in a private hospital in Macao. Individuals aged 50 to 75 years old who are bothering least a 30 pack-year smoking history and currently smoke or have quit within the past 15 years, were included. People without risk factors who underwent chest LDCT at the health center of the hospital were approved as a control group. The detection rate of lung cancer, pulmonary nodules were analyzed. Results: The detection rate of pulmonary nodules in the high-risk group are higher than that in the control group, however, there is no significant difference in the detection rate of lung cancer between the two groups. Adenocarcinoma is a major type of lung cancer in Macau male population. Therefore, screen-eligible populations should to be redefined in the future lung cancer screening trial in Macau.