雌激素受體、孕激素受體表達與子宮內膜癌臨床病理特徵的關係

Expression of estrogen receptor and progesterone receptor in endometrial cancer and their relationship with clinical pathological characteristics

10.12408/J.issn2223-4462.2024.01.003

洪宇(HONG Yu)；韋潔貞(WEI Jie Zhen)；李純科(LI Chun Ke)；梁海琪(LIANG Hai Qi)

雌激素受體 ； 孕激素受體 ； 子宮內膜癌 ； 臨床病理特徵 ； Estrogen receptor ； Progesterone receptor ； Clinical pathological characteristics

鏡湖醫學

24卷1期（2024 / 06 / 01）

11 - 13+48

繁體中文;英文

目的：探討子宮內膜癌患者子宮內膜組織中雌激素受體（ER）、孕激素受體（PR）表達與其臨床病理特徵的關係。方法：收集2016年1月～2022年8月間在鏡湖醫院婦產科住院行手術治療的子宮內膜癌患者的臨床資料及病理結果，應用免疫組化法檢測其子宮內膜組織中ER、PR的表達情況。結果：子宮內膜樣癌組織中ER、PR表達的陽性率分别為97.2%和94.4%，均明顯高於非子宮內膜樣癌組織；子宮內膜樣癌組織中ER、PR的表達隨臨床分期的級别升高而降低，且臨床II、III期患者癌組織中ER、PR表達明顯低於I期患者，伴有淋巴結轉移患者的子宮內膜組織中ER、PR表達均較無淋巴結轉移者低，但僅PR表達有統計學差異；ER、PR的表達與肌層侵犯程度無關，脈管浸潤者ER、PR表達較脈管未浸潤者低，但差異無統計學意義。結論：ER、PR表達降低與EC患者腫瘤細胞分化程度、臨床分期、淋巴結轉移存在一定關係，可能有助於判斷疾病的嚴重程度。

Objective: To investigate the relationship between the expression of estrogen receptor (ER) and progesterone receptor (PR) in endometrial tissues of patients with endometrial cancer and their clinicopathological characteristics. Methods: Clinical data and pathological data from endometrial cancer patients who underwent surgery at the Department of Obstetrics and Gynecology of Macau Kiang Wu hospital from January 2016 to August 2022 were collected. Immunohistochemical methods were used to detect the expression of ER and PR in their endometrial tissues. Results: The positive rates of ER and PR expression in endometrioid carcinoma tissues were 97.2% and 94.4%respectively, which were significantlygreater than those in non-endometrioid carcinoma tissues; The expression of ER and PR in endometrioid carcinoma tissue decreased with the increasing of clinical stage, and the expression of ER and PR in cancer tissue of clinical stage II and III patients was significantly lower than that in cancer tissue fromstage I patients. The expression of ER and PR in endometrial tissue of patients with lymph node metastasis waslower than that in patients without lymph node metastasis, but only PR expression was significantly different; The expression of ER and PR was not related to the depth of myometrium invasion. The expression of ER and PR in patients with lymphovascular space invasion was lower than that in patients without invasion, but the difference was not statistically significant. Conclusion: The decreased expression of ER and PR is related to the degree of tumor cell differentiation, clinical stage, and lymph node metastasis in EC patients, which may help to determine the severity of the disease.