新生兒早發型敗血症管理策略的比較

Comparison of management protocol for neonatal early-onset sepsis

10.12408/J.issn2223-4462.2024.01.007

楊咏山(IEONG Weng San)；葉一蓮(YE Yi Lian)；陳苑琪(CHAN Un Kei)；簡佩君(KAN Pui Kwan)

新生兒早發型敗血症 ； 敗血症風險計算器 ； 抗菌治療 ； 新生兒 ； Neonatal early-onset sepsis ； Sepsis risk calculator ； Antibiotics management ； Newborn

鏡湖醫學

24卷1期（2024 / 06 / 01）

24 - 26

繁體中文;英文

目的：為新生兒早發型敗血症（early-onset sepsis,EOS）的有效管理和抗菌素需求之間取得平衡提供參考依據。方法：回顧性分析2021年1月～12月本院收治之新生兒早發型敗血症，收集臨床表現、實驗室結果及母親高危因素等數據。比較現行之管理策略與用敗血症風險計算器分析後建議之策略。結果：共收集157例，兩種策略在抗菌治療需求及治療天數上存在統計學差異（P<0.05）。安全性方面，一例被計算器評級無需抗菌之患兒出現病情轉差。結論：兩種策略對本院新生兒早發型敗血症的處置各有優缺點。

Objective: To provide a reference for the balance between the effective management and antibiotic requirement in neonatal early-onset sepsis (EOS). Methods: A retrospective analysis was performed on our 157 EOS patients from January 2021 to December 2021.Clinical manifestations, laboratory data, and maternal high-risk factors were collected. The data were analyzed using the Neonatal Early-Onset Sepsis Calculator, and compare the antibiotics requirement between two management protocol. Results: Compared with two management protocol, there were statistical differences in antibiotics requirement and treatment days (P <0.05) for these 157 case. In terms of safety, a child who was graded to be clinically observed experienced deterioration during progress. Conclusion: Both potocol have advantages and disadvantages for our EOS management.