A case of secretory breast carcinoma with ETV6-NTRK3 fusion gene during childhood

兒童期ETV6-NTRK3融合基因分泌性乳癌PA 1例

10.12408/J.issn2223-4462.2024.01.022

TAI Wai Meng(戴慧明)；CHAN Kin Iong(陳建勇)；WONG Peng Hong(黃炳紅)；XU De Li(徐德利)；WEN Jian Ming(文劍明)

鏡湖醫學

24卷1期（2024 / 06 / 01）

62 - 63+ii

英文;繁體中文

Secretory carcinoma is a rare breast cancer. We report a case of secretory carcinoma occurred in childhood. A 7-year-old girl had a history of a mass in the breast for 4 years. The tumor grew slowly and well circumscribed, mimicking benign lesions on imaging. After breast lumpectomy, a diagnosis of secretory carcinoma was made based on its histological morphology, immunohistochemical reaction, and molecular profile. Herein, we report the process of diagnosis, and treatment of this rare case. Secretory carcinoma is a rare subtype of breast cancer, accounting for less than 0.15% of all breast cancers. It occurs over a wide range of agesin both sexes with a preference for females. However, in childhood, secretory carcinomais a relatively common breast cancer. Clinically, childhood secretory carcinoma presents as a painless, firm, well-circumscribed, and palpable mass near the nipple, and grows slowly and indolently. On ultrasonography, secretory carcinoma appears as a solid, slightly lobulated, hypoechoic mass that mimics a benign lesion such as fibroadenoma. Thus, a biopsy should be carried out to avoid misdiagnosis if a palpable mass appeared in the childhood breast. Herein, we report a case of a seven-year-old girl with secretory carcinoma of the breast and its treatment.