以二氧化錫薄膜為基底之多重離子感測器之研製及應用

Fabrication and Applications of the Multi-ions Sensors Based on SnO2 Thin Film

10.6840/cycu201100532

鄭瑞福

二氧化錫/氧化銦錫玻璃 ； 酸鹼感測器 ； 鉀離子感測器 ； 鈉離子感測器 ； 氯離子感測器 ； 無線居家照護系統 ； 多重離子感測系統 ； 非理想效應校正方法 ； pH sensor ； Potassium sensor ； Tin oxide (SnO2)/ indium tin oxide (ITO) glass ； Sodium sensor ； Chloride sensor ； Non-ideal effects calibration method ； Multi-ions sensing system ； Wireless home-care system.

中原大學電子工程研究所學位論文

2011年

博士

英文

在本論文中，係以二氧化錫(Tin oxide, SnO2)/氧化銦錫(Indium tin oxide glass, ITO glass)玻璃為基材進行鉀、鈉與氯三種全固態離子感測器之研製。三種離子感測器之感測膜係分別由相對之聚氯乙烯(Polyvinylchloride, PVC)、塑化劑(Dis (2-ethylhexyl) sebacate, DOS)、離子選擇物(Ionophores)與離子添加物(Additives)混合而成。 經過最佳化實驗之後，鉀離子感測器之最佳重量比是PVC: DOS: Valinomycin: KTpClPB = 33:66:4:2、鈉離子感測器之最佳重量比是PVC: DOS: B12C4: NaTFBD = 33:66:2:5與氯離子感測器之最佳重量比是PVC: DOS: ETH9033: TDDMACl = 33:66:2:5。在此最佳化條件下，三種感測器之感測度、線性區間、最低偵測極限、反應時間與壽命時間分別被量測出來。此外，三種感測器的選擇係數係以電壓匹配法(Matched potential method, MPM)為模式也被量測出來。另外，鈉離子感測器與氯離子感測器也被應用於量測眼鏡沖洗緩衝液(Rinsing solution for contact lenses)上。 在本論文中，亦發展結合硬體與軟體方式之非理想效應校正方法，此非理想效應校正方法亦應用於全固態鉀離子感測器上。非理想效應之時漂和遲滯的測量條件被設定為：時漂持續時間為12個小時，遲滯迴圈為10-3M→10-1M→10-3M→10-5M→10-3M氯化鉀(KCl)溶液濃度，遲滯迴圈之總量測時間為5分鐘。時漂校正濃度為10-2M和10-5M氯化鉀溶液濃度。另外，交流阻抗分析儀(Alternated current impedance analyzer)也被使用於測量感測膜的交換阻抗。交流阻抗分析儀之量測結果被用於解釋感測膜之遲滯和感測膜的交換阻抗之間關係。 最後，本論文亦發展包括酸鹼、鉀、鈉和氯之多重離子感測器並結合無線居家照護系統。多重離子感測器在不同測試溶液下之交連(Correlation)係數亦被探討。本論文亦探討無線居家照護系統之感測器模組、可攜式模組、藍芽(Bluetooth)模組、個人電腦(Personal computer, PC)的終端與可攜式單元。測量結果之數據記錄和被顯示係使用Lab-VIEW軟件所設計的圖形化界面。結果，此無線居家照護系統可即時且順利地監測和傳送量測信號。

In this thesis, three all-solid-state sensors include potassium, sodium, and chloride based on tin oxide (SnO2)/ indium tin oxide (ITO) glass were developed. The sensing membranes of three sensors were prepared by mixing poly (vinyl chloride) (PVC), bis (2-ethylhexyl) sebacate (DOS), ionophores, and additives. After the optimum experimental trials, the best weight ratio of the potassium sensor was PVC: DOS: Valinomycin: KTpClPB = 33:66:4:2. The sodium sensor was PVC: DOS: B12C4: NaTFBD = 33:66:2:5. And, the chloride sensor was PVC: DOS: ETH9033: TDDMACl = 33:66:2:5. In the optimum condition, the sensitivity, linear concentrations, low detection limit, response time, and lifetime of the sensors were measured. Moreover, the selectivity coefficients by matched potential method (MPM) of the sensors were tested. In addition, sodium and chloride sensors were applied to detect rinsing solution for contact lenses. In this thesis, a non-ideal effects calibration method combining of hardware and software was developed, and apply this calibration method to an all-solid-state potassium electrode. The measurement conditions of drift and hysteresis were set as below; the drift time was last for 12 hours, the hysteresis loop was 10-3M→10-1M→10-3M→10-5M→10-3M KCl solutions, and the total loop time of hysteresis measurement was 5 min. Calibration of drift behaviors were in 10-2M and 10-5M KCl solutions. In addition, the alternated current (AC) impedance analyzer was used to measure the transfer impedance of the sensing membrane. The experimental results obtained by the AC impedance analyzer were used to explain the relationship between the hysteresis and transfer impedance of the sensing membrane. Finally, this thesis developed a multi-ions sensing system includes pH, potassium, sodium, and chloride ion sensors with a wireless home-care system. The correlations of the sensors in multi-ions sensing system under different test solutions were discussed. This thesis also investigated sensors module, portable module, Bluetooth module, personal computer (PC) terminal, and portable unit of the wireless home-care system. A graphical measurement interface for data recorded and measurement results displayed was designed by Lab-VIEW software. Therefore, the wireless home-care system could successfully monitor and transmit the sensing signals in real time.

1. [1] Yoshio Umezawa, Philippe Buhlmann, Kayoko Umezawa, Koji Tohda, and Shigeru Ameriya, “Potentiomseric selectivity coefficients of ion-selective electrodes part I. inorganic cations”, Pure Appl. Chem., Vol. 72, No. 10, pp. 1851–2082, 2000.
   連結：
2. [2] A. Errachid, J. Bausells, N. Zine, H. Jaffrezic, C. Martelet, N. Jaffrezic-Renault, and M. Charbonnier, ”Analytical features of K+-sensitive membrane obtained by implantation in silicon dioxide films”, Materials Science and Engineering, Vol. C 21, pp.9-13, 2002.
   連結：
3. [3] Eugenia Totu, Ana Maria Josceanu, and Arthur K. Covington, “Improved potassium-selective membrane using valinomycin as ionophore for ion-selective microdevices”, Materials Science and Engineering C, Vol. 18, pp.87–91, 2001.
   連結：
4. [4] Lee Yook Heng and Elizabeth A.H. Hall, ”Assessing a photocured self-plasticised acrylic membrane recipe for Na+ and K+ ion selective electrodes”, Analytica Chimica Acta, 443, pp.25-40, 2001.
   連結：
5. [5] T. Momma, S. Komaba, M. Yamamoto, T. Osaka, and S. Yamauchi, ”All-solid-state potassium-selective electrode using double-layer film of polypyrrole polyanion composite and plasticized poly(vinyl chloride) containing valinomycin”, Sensors and Actuators, B 24-25, pp.724-728, 1995.
   連結：
6. [6] Mohr, G. J, Lehmann, F., Haider, C., Wolfbeis, O. S., and Murkovic, I., “Application of potential-sensitive fluorescent dyes in anion- and cation- sensitive polymer membranes”, Sensors and Actuators B, Vol. 39, pp. 239-245, 1997.
   連結：
7. [7] F. Montiel, P. Aimar, and P. Montoriol , “Continuous monitoring of sodium concentration in blood during haemodialysis by a selective membrane and conductivity sensor”, Sensors and Actuators B, Vol.26-27, pp.465-467, 1995.
   連結：
8. [8] Lee-Soon Park, Young-Jun Hur, and Byumg-Ki Sohn, ”Effect of membrane structure on the performance of field-effect transistor potassium-sensitive sensor”, Sensors and Actuators A, Vol. 57, pp.239-243, 1996.
   連結：
9. [9] D. N. Reinhoudt, “Durable chemical sensors based on field-effect transistors”, Sensors and Actuators B, Vol. 24-25, pp.197-200, 1995.
   連結：
10. [10] David E. Carden, Dermot Diamond, and Anthony J. Miller, "An improved Na+-selsetive microelectrode for intracellular measurements in plant cells", Journal of Experimental Botany, Vol. 52, pp. 1353-1359, 2001.
    連結：
11. [11] Gillian McMahon, Shane O’Malley, Kieran Nolan, and Dermot Diamond , "Important Calixarene Derivatives-their Synthesis and Applications", Arkivoc, Vol. vii, pp. 23-31, 2003.
    連結：
12. [12] G. Hogg, O. Lutze, and K. Cammann, ”Novel membrane material for ion-selective field-effect transistors with extended lifetime and improved selectivity”, Analytica Chimica Acta, Vol. 335, pp.103-109, 1996.
    連結：
13. [13] Dong Liu, Ravi K. Meruva, Richard B. Brown, and Mark E. Meyerhoff, “Enhancing EMF stability of solid-state ion-selective sensors by incorporating lipophilic silver-ligand complexes within polymeric films”, Analytica Chimica Acta, Vol. 321, pp.173-183, 1996.
    連結：
14. [14] Shaojun Dong, Zhisheng Sun, and Ziling Lu, “Chloride chemical sensor based on an organic conducting polypyrrole polymer”, Analyst, Vol. 113, pp.1525-1528, 1988.
    連結：
15. [15] Syotaro Oka, Yaichiro Sibazaki, and Shu Tahara, “Direct potentiometric determination of Chloride ion in whole blood”, Anal. Chem., Vol. 53, pp.588-593, 1981.
    連結：
16. [16] Klara Bezegh, Andras Bezegh, Jiri Janata, Urs Oesch, Aiping Xu, and Wilhelm Simon, “Multisensing ion-selective field-effect transistors prepared by ionophore doping technique”, Anal. Chem., Vol. 59, pp.2846-2848, 1987.
    連結：
17. [17] Markus Rothmaier and Wilhelm Simon, “Chloride-selective electrodes based on mercury organic compounds as neutral carriers”, Analytica Chimica Acta, Vol.271, pp.135-141, 1993.
    連結：
18. [18] Min Jong Cha, Jae Ho Shin, Bong Kyun Oh, Chang Yong Kim, Geun Sig Cha, Doo Soon Shin, and Bokhee Kim, “Asymmetric cellulose acetate membrane-based carbonate- and chloride- selective electrodes”, Analytica Chimica Acta, Vol. 315, pp.311-319, 1995.
    連結：
19. [20] Markus Rothmaier, Ulrich Schaller, Werner E. Morf, and Erno Pretsch, “Response mechanism of anion-selective electrodes based on mercury organic compounds as ionophores”, Analytica Chimica Acta, Vol. 327, pp.17-28, 1996.
    連結：
20. [21] Barbara Ballarin, Marco Morigi, Erika Scavetta, Renato Seeber, and Domenica Tonelli, “Hydrotalcite-like compounds as ionophores for the development of anion potentiometric sensors”, Journal of Electroanalytical Chemistry, Vol. 492, pp.7-14, 2000.
    連結：
21. [22] R. Zielinska, E. Mulik, A. Michalska, S. Achmatowicz, M. and Maj-Zurawska, “All-solid-state planar miniature ion-selective chloride electrode”, Analytica Chimica Acta, Vol. 451, pp.243-249, 2002.
    連結：
22. [23] Andrey Bratov, Natalia Abramova, and Carlos Dominguez, “Investigation of chloride sensitive ISFETs with different membrane compositions suitable for medical applications”, Analytica Chimica Acta, Vol. 514, pp.99-106, 2004.
    連結：
23. [24] Andrey Legin, Sergey Makarychev-Mikhailov, Dmitry Kirsanov, John Mortensen, and Yuri Vlasov, “Solvent polymeric membranes based on tridodecylmethylammomium chloride studied by potentiometry and electrochemical impedance spectroscopy”, Analytica Chimica Acta, Vol. 514, pp.107-113, 2004.
    連結：
24. [25] Andrey Legin, Sergey Makarychev-Mikhailov, John Mortensen, and Yuri Vlasov, “Potentiometric and impedance studies of membranes based on anion-exchanger and lipophilic inert electrolyte ETH 500”, Electrochimica Acta, Vol. 49, pp.5203-5207, 2004.
    連結：
25. [26] John A. Chaney, Pehr E. Pehrsson, “Work function changes and surface chemistry of oxygen, hydrogen, and carbon on indium tin oxide”, Applied Surface Science, Vol. 180, pp.214-226, 2001.
    連結：
26. [27] R. Schlaf, H. Murata, and Z.H. Kafafi, “Work function measurements on indium tin oxide films”, Journal of Electron Spectroscopy and Related Phenomena, Vol. 120, pp.149–154, 2001.
    連結：
27. [28] T. Sahm, A. Gurlo, N. Barsan, U. Weimar, and L. Madler, “Fundamental studies on SnO2 by means of simultaneous work function change and conduction measurements”, Thin Solid Films, Vol. 490, pp. 43–47, 2005.
    連結：
28. [29] Li-Lun Chi, Jung-Chuan Chou, Wen-Yaw Chung, Tai-Ping Sun, and Shen-Kan Hsiung, “Study on extended gate field effect transistor with tin oxide sensing membrane”, Material Chemistry and Physics, Vol.63, pp.19-23, 2000.
    連結：
29. [30] Li-Lun Chi, Li-Ti Yin, Jung-Chung Chou, Wen-Yaw Chung, Tai-Ping Sun, Kuang-Pin Hsiung, and Shen-Kan Hsiung, “Study on separative structure of EnFET to detect acetylcholine”, Sensors and Actuators B, Vol.71, pp.68-72, 2000.
    連結：
30. [31] Li Te Yin, Jung Chuan Chou , Tai Ping Sun, Wen Yaw Chung, and Shen Kan Hsiung, “Study of indium tin oxide thin film for separative extended gate ISFET”, Materials Chemistry and Physics, Vol. 70, PP.12-16, 2000.
    連結：
31. [32] Li Te Yin, Jung Chuan Chou, Wen Yaw Chung, Tai Ping Sun, and Shen Kan Hsiung, “Study on separate structure extended gate H+-ion sensitive field effect transistor on a glass substrate”, Sensors and Actuators B, Vol. 71, pp. 106-111, 2000.
    連結：
32. [33] Li-Te Yin, Jung-Chuan Chou, Wen-Yaw Chung, Tai-Ping Sun, Kuang-Pin Hsiung, and Shen-Kan Hsiung, “Glucose ENFET doped with MnO2 powder”, Sensors and Actuators B, Vol.76, pp.187-192, 2001.
    連結：
33. [34] Maria Arduini, Lidia Armelao, Silvia Gross, Fabrizio Mancin, Silvia Marcuz, Mariachiara Montolli, and Cinzia Sada, “Chemical optimisation of a sol–gel procedure for the development of fluorescence Cu(II) nanosensors”, Applied Surface Science, Vol. 253, pp.7178–7187, 2007.
    連結：
34. [35] Dara L. Woerdeman, Wei Ou, Joseph L. Lenhart, and Richard S. Parnas, “Interpreting the signal from a localized fluorescence sensor: a study by angle-resolved XPS and dynamic SIMS”, Journal of Colloid and Interface Science, Vol. 262, pp.594–602, 2003.
    連結：
35. [36] Vadapalli Chandrasekhar, Prasenjit Bag, and Mrituanjay D. Pandey, “Phosphorus-supported multidentate coumarin-containing fluorescence sensors for Cu2+”, Tetrahedron, Vol.65, pp.9876–9883, 2009.
    連結：
36. [37] Cida’lia M. G. dos Santos, Thomas McCabe, and Thorfinnur Gunnlaugsson, “Selective fluorescent sensing of chloride”, Tetrahedron Letters, Vol. 48, pp.3135–3139, 2007.
    連結：
37. [38] Azizul Isha, Nor Azah Yusof, Musa Ahmad, Dedy Suhendra, Wan Md Zin Wan Yunus, and Zulkarnain Zainal, “Optical fibre chemical sensor for trace vanadium(V) determination based on newly synthesized palm based fatty hydroxamic acid immobilized in polyvinyl chloride membrane”, Spectrochimica Acta Part A, Vol. 67, pp.1398–1402, 2007.
    連結：
38. [39] Yoko Akiyama, Hemant Sodaye, Yuji Shibahara, Yoshihide Honda, Seiichi Tagawa, and Shigehiro Nishijim, “Study on gamma-ray-induced degradation of polymer electrolyte by pH titration and solution analysis”, Polymer Degradation and Stability, Vol. 95, pp.1-5, 2010.
    連結：
39. [40] Mohammad K. Amini, Tahereh Momeni-Isfahani, Jafar H. Khorasani, and Mohammad Pourhossein, “Development of an optical chemical sensor based on 2-(5-bromo-2-pyridylazo)-5-(diethylamino) phenol in Nafion for determination of nickel ion”, Talanta, Vol. 63, pp.713–720, 2004.
    連結：
40. [41] Ali A. Ensafi, A. Katiraei Far, and S. Meghdadi, “Highly selective optical-sensing film for lead(II) determination in water samples”, Journal of Hazardous Materials, Vol. 172 pp.1069–1075, 2009.
    連結：
41. [42] Esmaeil Shamsa and Roohollah Torabi, “Determination of nanomolar concentrations of cadmium by anodic-stripping voltammetry at a carbon paste electrode modified with zirconium phosphated amorphous silica”, Sensors and Actuators B, Vol. 117, pp.86–92, 2006.
    連結：
42. [43] Ali R. Zanganeh and Mohammad K. Amini, “A potentiometric and voltammetric sensor based on polypyrrole film with electrochemically induced recognition sites for detection of silver ion”, Electrochimica Acta, Vol. 52, pp.3822–3830, 2007.
    連結：
43. [44] Vinod K. Gupta, Rajendra N. Goyal, and Ram A. Sharma, “Comparative studies on Neodymium (III)-selective PVC membrane sensors”, Analytica Chimica Acta, Vol. 647, pp.66-71, 2009.
    連結：
44. [45] V.K. Gupta, Manoj K. Pal, and Ashok K. Singh, “Comparative evaluation of Dy(III) selective poly(vinyl) chloride based membrane electrodes of macrocyclic tetraimine Schiff bases”, Talanta, Vol.79, pp.528-533, 2009.
    連結：
45. [46] V. K. Gupta, A. K. Singh, and Barkha Gupta, “Electroanalytical performance of Terbium (III) selective sensor based on a neutral ionophore in environmental and medicinal samples”, Anal. Bioanal.Chem., Vol.390, pp.2171-2181, 2008.
    連結：
46. [47] Vinod Kumar Gupta, A.K. Singh, and Barkha Gupta, “A Cerium (III) selective poly vinyl chloride membrane based on a Schiff base complex of N, N-Bis [2-(salicylideneamino) ethyl] ethane-1, 2-diamine”, Analytica Chimica Acta, Vol.575, pp.198-204, 2006.
    連結：
47. [48] Vinod Kumar Gupta, Rainer Ludwig, and Shiva Agarwal, “Strontium (II) Sensor Based on a Modified Calix[6]arene in PVC Matrix”, Analytical Sciences, Vol.21, pp.293-296, 2005.
    連結：
48. [49] Vinod K. Gupta, Ajay K. Jain, U. Khurana, and L.P. Singh, “PVC Based Neutral Carrier and Organic Exchanger Membranes as Sensors for the Determination of Ba2+ and Sr2+”, Sensors and Actuators B, Vol.55, pp.201-211, 1999.
    連結：
49. [50] Vinod K. Gupta, Ajay K. Jain, Lok P. Singh, Upendra Khurana, and Pankaj Kumar, “Molybdate Sensor based on 5,10,15,20- etraphenylporphyrinatocobalt Complex in PVC matrix”, Analytica Chimica Acta, Vol.379, pp.201-208, 1999.
    連結：
50. [51] Vinod K. Gupta, R. Mangla, U. Khurana, and Pankaj Kumar, “Determination of uranyl Ions using Poly (Vinyl Chloride) based4-tert-butylcalix [6] arene membrane sensor”, Electroanalysis, Vol. 11, pp.573-576, 1999.
    連結：
51. [52] Ajay K. Jain, Vinod K. Gupta, Lok P. Singh, and Upendra Khurana, “Novel PVC-based membrane sensors selective for vanadyl ions”, Talanta, Vol. 46, pp.1453-1460, 1998.
    連結：
52. [53] A. K. Jain, V. K. Gupta, U. Khurana, and Lok P. Singh, “A new membrane Sensor for UO2+, based on 2 droxyacetophenoneoxime -thioureatrioxane Resin”, Electroanalysis, Vol. 9, pp.857-860, 1997.
    連結：
53. [54] Ajay K. Jain, Vinod K. Guptu, Lok P. Singh, and Upendra Khurana, “A new Cerium (IV) Vanadate-Based Solid Membrane Electrode for Bismuth (III)”, Electroanalysis, Vol. 9, pp.1360-1364, 1997.
    連結：
54. [55] Suresh K. Srivastava, Vinod K. Guptu, and Suresh Jain, “A PVC-Based Benzo-15-Crown-5 Membrane Sensor for Cadmium”, Electroanalysis, Vol. 8, pp.938-940, 1996.
    連結：
55. [56] A.K. Jain, V.K. Gupta, S. Radi, L.P. Singh, and J.R. Raisoni, “A comparative study of Pb2+ sensors based on derivatized tetrapyrazole and calix[4]arene receptors”, Electrochimica Acta, Vol. 51, No. 12, pp.2547-2553, 2006.
    連結：
56. [57] V. K. Gupta, “Potentiometric sensors for heavy metals- an overview”, Chimia, Vol. 59, pp.209-217, 2005.
    連結：
57. [58] A. K. Jain, V.K. Gupta, and J. R. Raisoni, “Strontium (II) selective potentiometric sensor based on ester derivative of 4-tert-butylcalix(8)arene in PVC matrix”, Sensors, Vol. 4, pp.115-124, 2004.
    連結：
58. [59] A. K. Jain, V. K. Gupta, L. P. Singh, and U. Khurana, “Macrocycle based Membrane Sensors for the determination of Cobalt (II) ions”, Analyst, Vol.122, pp.583-586, 1997.
    連結：
59. [60] A. K. Jain, V. K.Gupta, and L. P. Singh, “Neutral Carrier and Organic Resin Based Membranes as Sensors for Uranyl ions”, Analytical Proceedings including Analytical Communications, Vol. 32, pp.263-265 , 1995.
    連結：
60. [61] S. K. Srivastava, V. K. Gupta, M. K. Dwivedi, and S. Jain, “Caesium PVC-Crown (dibenzo-24-crown-8) based membrane sensor”, Analytical Proceedings including Analytical Communications, Vol. 32, pp.21-23, 1995.
    連結：
61. [62] S. K. Srivastava, V. K. Gupta, and S. Jain, “Determination of lead using poly (vinyl chloride) based crown ether membrane”, Analyst , Vol. 120, pp.495-498, 1995.
    連結：
62. [63] A. K. Jain, V. K.Gupta, B. B. Sahoo, and L. P. Singh, “Copper (II)-Selective Electrodes Based on Macrocyclic Compounds”, Analytical Proceedings including Analytical Communications, Vol. 32, pp.99-101 , 1995.
    連結：
63. [64] Jung Chuan Chou, Hsjian Ming Tsai, Ching Nan Shiao, and Jin Sung Lin, “Study and simulation of the drift behaviour of hydrogenated amorphous silicon gate pH-ISFET”, Sensors and Actuators B, Vol. 62, pp.97-101, 2000.
    連結：
64. [66] Jung Chuan Chou and Yii Fang Wang, “Preparation and study on the drift and hysteresis properties of the tin oxide gate ISFET by the sol-gel method”, Sensors and Actuators B, Vol. 86, pp.58-62, 2002.
    連結：
65. [67] George T. Yu, “The diffusivity of mobile hydrogen ion in pH-glass membrane”, Chemical Physics Letters, Vol. 384, pp.124-127, 2004.
    連結：
66. [68] Chu Neng Tsai, Jung Chuan Chou, Tai Ping Sun, and Shen Kan Hsiung, “Study on the sensing characteristics and hysteresis effect of the tin oxide pH electrode”, Sensors and Actuators B, Vol. 108, pp.877-882, 2005.
    連結：
67. [69] Chu Neng Tsai, Jung Chuan Chou, Tai Ping Sun, and Shen Kan Hsiung, “Study on the Time-Dependent slow response of the tin oxide pH electrode”, IEEE Sensors Journal, Vol. 6, No. 5, pp.1243-1249, 2006.
    連結：
68. [71] Luc Bousse, Shahriar Mostarshed, Bart van der Schoot, and N.F. de Rooij, “Comparison of the hysterrsis of Ta2O5 and Si3N4 pH-sensing insulators”, Sensors and Actuators B, Vol. 17, pp.157-164, 1994.
    連結：
69. [73] Y. Umezawa, K. Umezawa, and H. Sato, “Selectivity coefficients for ion-selective electrodes: Recommended methods for reporting values”, Pure and Application Chemical, Vol.67, pp.507-518, 1995.
    連結：
70. [74] T. Momma, S. Komaba, M. Yamamoto, T. Osaka, and S. Yamauchi, ”All-solid-state potassium-selective electrode using double-layer film of polypyrrole polyanion composite and plasticized poly(vinyl chloride) containing valinomycin”, Sensors and Actuators B, Vol. 24, pp.724-728, 1995.
    連結：
71. [75] Eric Bakker, Philippe Bühlmann, and Ernö Pretsch, “The phase-boundary potential model”, Talanta, Vol. 63, pp.3-20, 2004.
    連結：
72. [76] Yuii Miyahara, Koutarou Yamashita, Satoshi Ozawa, and Yoshio Watanabe, “Shift and drift of electromotive forces of solid-state electrodes with ion-selective liquid membranes”, Analytica Chinica Acta, Vol. 331, pp.85-95, 1996.
    連結：
73. [77] Toshiyuki Momma, Mayumi Yamamoto, Shinichi Komaba, and Tetsuya Osaka, “Analysis of the long-term potential stability of an all-solid-state potassium-selective electrode with electroactive polypyrrole film”, Journal of Electroanalytical Chemistry, Vol. 407, pp.91-96, 1996.
    連結：
74. [78] Monia Fibbioli, Krisanu Bandyopadhyay, Sheng-Gao Liu, Luis Echegoyen, Olivier Enger, François Diederich, Philippe Bühlmann, and Ernö Pretsch, “Redox-active self-assembled monolayers as novel solid contacts for ion-selective electrodes”, Chemical Communication, pp.339-40, 2000.
    連結：
75. [79] Monia Fibbioli, Werner E. Morf, Martin Badertscher, Nicolaas F. de Rooij, and ErnoÈ Pretsch, “Potential drifts of solid-contacted ion-selective electrodes due to zero-current ion fluxes through the sensor membrane”, Electroanalysis, Vol. 12, No. 16, pp.1286-1292, 2000.
    連結：
76. [80] Fayi Song, Jeonghan Ha, Byungho Park, Tae Hyoung Kwak, In Tae Kim, Hakhyun Nam, and Geun Sig Cha, “All-solid-state carbonate-selective electrode based on a molecular tweezer-type neutral carrier with solvent-soluble conducting polymer solid contact”, Talanta, Vol. 57, pp.263-270, 2002.
    連結：
77. [81] H. Kaden, H. Jahn, and M. Berthold, “Study of the glass/polypyrrole interface in an all-solid-state pH sensor”, Solid State Ionics, Vol. 169, pp.129-133, 2004.
    連結：
78. [82] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, and Shen-Kan Hsiung, “All-solid-state separated potassium electrode based on SnO2/ITO glass”, Journal of The Electrochemical Society, Vol. 154, No. 11, pp.J369-J374, 2007.
    連結：
79. [83] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, Shen-Kan Hsiung and, Hui-Ling Kao, “Study on the drift for the all-solid-state potassium electrode.”, The 6th Asian Conference on Electrochemistry (ACEC), May 11-14, 2008, Taipei, Taiwan.
    連結：
80. [85] M. S. Belluzo, M. É. Ribone, and C. M. Lagier, “Assembling amperometric biosensors for clinical diagnostics.”, Sensors, Vol. 8, pp.1366–1399, 2008.
    連結：
81. [86] R. Koncki, “Recent developments in potentiometric biosensors for biomedical analysis.”, Analytica Chimica Acta, Vol. 599, pp. 7-15, 2007.
    連結：
82. [87] E. Bakker, “Electrochemical sensors.”, Anal. Chem., Vol. 76, pp. 3285-3298, 2004.
    連結：
83. [88] Li-Lun Chi, Jung-Chuan Chou, Wen-Yaw Chung, Tai-Ping Sun, and Shen-Kan Hsiung, “Study on extended gate field effect transistor with tin oxide sensing membrane.”, Material Chemistry and Physics, Vol.63, pp.19-23, 2000..
    連結：
84. [89] Li-Lun Chi, Li-Ti Yin, Jung-Chung Chou, Wen-Yaw Chung, Tai-Ping Sun, Kuang-Pin Hsiung, and Shen-Kan Hsiung, “Study on separative structure of EnFET to detect acetylcholine”, Sensors and Actuators B, Vol.71, pp.68-72, 2000.
    連結：
85. [90] Li Te Yin, Jung Chuan Chou , Tai Ping Sun, Wen Yaw Chung, and Shen Kan Hsiung, “Study of indium tin oxide thin film for separative extended gate ISFET”, Materials Chemistry and Physics, Vol. 70, pp.12-16, 2000.
    連結：
86. [91] Li Te Yin, Jung Chuan Chou, Wen Yaw Chung, Tai Ping Sun, and Shen Kan Hsiung, “Study on separate structure extended gate H+-ion sensitive field effect transistor on a glass substrate”, Sensors and Actuators B, Vol. 71, pp. 106-111, 2000.
    連結：
87. [92] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, and Shen-Kan Hsiung, “Application of sodium ion sensor based on the SnO2/ITO glass in the detection of rinsing solution for contact lenses.”, Rare Metal Materials and Engineering, Vol.35, Suppl.3, pp. 240-241, 2006.
    連結：
88. [93] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, Shen-Kan Hsiung, and Hui-Ling Kao, “New calibration methods to eliminate the non-ideal effect of drift and hysteresis in all-solid-state potassium electrode.”, IEEE Sensors Journal. (In Press)
    連結：
89. [95] Lawrence C. Chirwa, Paul A. Hammond, Scott Roy, and David R. S. Cumming, “Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz.”, IEEE Transactions on Biomedical Engineering, Vol.50, No.4, pp.484-492, 2003.
    連結：
90. [96] Paul A. Hammond, Danish Ali, and David R. S. Cumming, “A system-on-chip digital pH Meter for use in a wireless diagnostic capsule.”, IEEE Transactions on Biomedical Engineering, Vol. 52, No.4, pp.687-694, 2005.
    連結：
91. [97] Erik A. Johannessen, Lei Wang, Li Cui, Tong Boon Tang, Mansour Ahmadian, Alexander Astaras, Stuart W. J. Reid, Philippa S. Yam, Alan F. Murray, Brian W. Flynn, Steve P. Beaumont, David R. S. Cumming, and Jonathan M. Cooper, “Implementation of multichannel sensors for remote biomedical measurements in a microsystems format.”, IEEE Transactions on Biomedical Engineering, Vol. 51, No.3, pp.525-535, 2004.
    連結：
92. [98] Yuan Hsiang Lin, I Chien Jan, Patrick Chow In Ko, Yen Yu Chen, Jau Min Wong, and Gwo Jen Jan, “A wireless PDA-based physiological monitoring system for patient transport.”, IEEE Transactions on Information Technology in Biomedicine, Vol.8, No.4, pp.439-447, 2004.
    連結：
93. [99] Wan Young Chung and Sung Ju Oh, “Remote monitoring system with wireless sensors module for room environment.”, Sensors and Actuators B, Vol.113, pp.64-70, 2006.
    連結：
94. [100] Alexandros Pantelopoulos and Nikolaos G. Bourbakis, “A survey on wearable sensor-based systems for health monitoring and prognosis.”, IEEE Transactions on systems, Man, and Cybernetics – Part C: Applications and Reviews, Vol. 40, No. 1, pp.1-12, 2010.
    連結：
95. [101] Hairong Yan, Hongwei Huo, Youzhi Xu, and Mikael Gidlund, “Wireless sensor network based E-health system – implementation and experimental results.”, IEEE Transactions on Consumer Electronics, Vol. 56, No. 4, pp.2288-2295, 2010.
    連結：
96. [102] C. Ruan, K. G. Ong, C. Mungle, N. J. Nickl, C. A. Grimes, and M. Paulose, “A wireless pH sensor based on the use of salt-independent micro-scale polymer spheres.”, Sensors and Actuators B, Vol.96, pp.61-69, 2003.
    連結：
97. [103] A. D. DeHennis and K. D. Wise, “A wireless microsystem for the remote sensing of pressure, temperature, and relative humidity.”, Microelectromechanical Systems, Vol. 14, pp.12-22, 2005.
    連結：
98. [104] G. A. DeMichele and P. R. Troyk, “Integrated multichannel wireless biotelemetry system.”, Engineering in Medicine and Biology Society, Vol. 4, pp.3372-3375 2003.
    連結：
99. [105] P. Valdastri, A. Menciassi, A. Arena, C. Caccamo, and P. Dario, “An implantable telemetry platform system for in vivo monitoring of physiological parameters.”, Information Technology in Biomedicine, Vol. 8, pp.271-278, 2004.
    連結：
100. [106] P. Mohseni and K. Najafi, “Wireless multichannel biopotential recording using an integrated FM telemetry circuit.”, Engineering in Medicine and Biology Society, Vol. 2, pp.4083-4086 2004.
     連結：
101. [108] T. H. Lin, W. J. Kaiser, and G. J. Pottie, “Integrated low-power communication system design for wireless sensor networks.”, IEEE Communications Magazine, Vol. 42, pp.142-150, 2004.
     連結：
102. [109] S. J. Winick, “The RF medium in the home, the move to spread spectrum.”, IEEE Transactions on Consumer Electronics, Vol.37, pp. 108-115, 1991.
     連結：
103. [110] K. Vaxevanakis, T. Zahariadis, and N. Vogiatzis, “A review on wireless home network technologies”, Mobile Computing and Communications Review Vol. 7, pp. 59-68, 2002.
     連結：
104. [111] S. A. M. Makki, N. Pissinou, and P. Daroux, “Mobile and wireless internet access.”, Computer Communications, Vol. 7, pp.734-746, 2003.
     連結：
105. [112] J. N. Al-Karaki and A. E. Kamal, “Routing techniques in wireless sensor networks: a survey.”, IEEE Wireless Communications, Vol.11, pp.6-28, 2004.
     連結：
106. [113] A. Dursch, D. C. Yen, and D. H. Shih, “Bluetooth technology: an exploratory study of the analysis and implementation frameworks.”, Computer Standards and Interfaces, Vol.26, pp.263-277, 2004.
     連結：
107. [116] Johan Bobacka, Ari Ivaska, and Andrzej Lewenstam, “Plasticizer-free all-solid-state potassium-selective electrode based on poly (3-octylthiophene) and valinomycin”, Analytica Chimica Acta 385, pp.195-202, 1999.
     連結：
108. [117] Shinichi Komaba, Junko Arakawa, Michiko Seyama, Tetsuya Osaka, Ikuo Satoh, and Sadako Nakamura, “Flow injection analysis of potassium using an all-solid-state potassium-selective electrode as a detector”, Talanta, Vol. 46, pp.1293–1297, 1998.
     連結：
109. [119] Amira M. El-Kosasy and Sawsan A. Abdel Razek, “Potentiometric determination of polyether ionophores growth promotors in animal feed preparations”, Journal of Pharmaceutical and Biomedical Analysis, Vol.29, pp.585-592, 2002.
     連結：
110. [120] Amira M. El-Kosasy and Sawsan A. Abdel Razek, “Potentiometric determination of polyether ionophores growth promotors in animal feed preparations”, Journal of Pharmaceutical and Biomedical Analysis, Vol.29, pp.585-592, 2002.
     連結：
111. [121] Johan Bobacka, Ari Ivaska, and Andrzej Lewenstam, “Plasticizer-free all-solid-state potassium-selective electrode based on poly (3-octylthiophene) and valinomycin”, Analytica Chimica Acta, Vol. 385, pp.195-202, 1999.
     連結：
112. [123] Li-Lun Chi, Jung-Chuan Chou, Wen-Yaw Chung, Tai-Ping Sun, and Shen-Kan Hsiung, “Study on extended gate field effect transistor with tin oxide sensing membrane”, Material Chemistry and Physics, Vol.63, pp.19-23, 2000.
     連結：
113. [124] Li-Lun Chi, Li-Ti Yin, Jung-Chung Chou, Wen-Yaw Chung, Tai-Ping Sun, Kuang-Pin Hsiung, and Shen-Kan Hsiung, “Study on separative structure of EnFET to detect acetylcholine”, Sensors and Actuators B, Vol.71, pp.68-72, 2000.
     連結：
114. [125] Li Te Yin, Jung Chuan Chou , Tai Ping Sun, Wen Yaw Chung, and Shen Kan Hsiung, “Study of indium tin oxide thin film for separative extended gate ISFET”, Materials Chemistry and Physics, Vol. 70, PP.12-16, 2000.
     連結：
115. [126] Li Te Yin, Jung Chuan Chou, Wen Yaw Chung, Tai Ping Sun, and Shen Kan Hsiung, “Study on separate structure extended gate H+-ion sensitive field effect transistor on a glass substrate”, Sensors and Actuators B, Vol. 71, pp. 106-111, 2000.
     連結：
116. [127] Li-Te Yin, Jung-Chuan Chou, Wen-Yaw Chung, Tai-Ping Sun, Kuang-Pin Hsiung, and Shen-Kan Hsiung, “Glucose ENFET doped with MnO2 powder”, Sensors and Actuators B, Vol.76, pp.187-192, 2001.
     連結：
117. [128] Richard P. Buck and Erno Lindner, “Recommendations for nomenclature of ion-selective electrodes”, Pure and Application Chemical, Vol.66, pp.2527-2536, 1994.
     連結：
118. [129] Y. Umezawa, K. Umezawa, and H. Sato, “Selectivity coefficients for ion-selective electrodes: Recommended methods for reporting values”, Pure Application. Chemistry. Vol. 67, pp.507-518, 1995.
     連結：
119. [130] Barbara Ballarin, Marco Morigi, Erika Scavetta, Renato Seeber, and Domenica Tonelli, “Hydrotalcite-like compounds as ionophores for the development of anion potentiometric sensors”, Journal of Electroanalytical Chemistry, vol.492, pp.7-14, 2000.
     連結：
120. [131] Hiroomi Hikawa, “FPGA implementation of self organizing map with digital phase locked loops”, Neural Networks, Vol. 18, pp.514-522, 2005.
     連結：
121. [132] Dong Hwan Kim, Sang Hyuck Kim, Jae Cheol Jo, and Sang Sam Choi, “Ultrahigh-speed clock recovery with optical phase lock loop based on four-wave-mixing in a semiconductor optical amplifier”, Optics Communications, Vol. 182, pp.329-334, 2000.
     連結：
122. [134] John A. Chaney and Pehr E. Pehrsson, “Work function changes and surface chemistry of oxygen, hydrogen, and carbon on indium tin oxide”, Applied Surface Science, vol 180, pp.214-226, 2001.
     連結：
123. [135] R. Schlaf, H. Murata, and Z.H. Kafafi, “Work function measurements on indium tin oxide films”, Journal of Electron Spectroscopy and Related Phenomena, Vol. 120, pp.149–154, 2001.
     連結：
124. [136] T. Sahm, A. Gurlo, N. Barsan, U. Weimar, and L. Madler, “Fundamental studies on SnO2 by means of simultaneous work function change and conduction measurements”, Thin Solid Films, Vol. 490, pp. 43–47, 2005.
     連結：
125. [137] Wei Zhang and Ursula E. Spichiger, “An impedance study of Mg2+ selective membranes”, Electrochimica Acta, Vol. 45, pp.2259-2266, 2000.
     連結：
126. [138] Claude Gabrielli, Patrick Hemery, Pierre Letellier, Michele Masure, Hubert Perrot, Marie-Isabelle Rahmi, and Mireille Turmine, “Investigation of ionic surfactant-selective electrodes by EIS”, Electrochimica Acta, Vol. 47, pp.2117-2126, 2002.
     連結：
127. [139] Claude Gabrielli, Patrick Hemery, Pierre Letellier, Michele Masure, Hubert Perrot, Marie-Isabelle Rahmi, and Mireille Turmine, “Investigation of ion-selective electrodes with neutral ionophores and ionic sites by EIS. II. Application to K+ detection”, Journal of Electroanalytical Chemistry, Vol. 570, pp.291-304, 2004.
     連結：
128. [140] Claude Gabrielli, Patrick Hemery, Pierre Letellier, Michele Masure, Hubert Perrot, Marie-Isabelle Rahmi, and Mireille Turmine, “Investigation of ion-selective electrodes with neutral ionophores and ionic sites by EIS. II. Application to Kt detection”, Journal of Electroanalytical Chemistry, Vol.570, pp.291-304, 2004.
     連結：
129. [141] P. Hassanzadeh, M. R. Yaftian, Z. Bahari, and D. Matt, “A coated graphite Thorium-ion selective potentiometric sensor based on a calyx[4]arene bearing phosphoryl groups”, Journal of the Chinese chemical society, Vol.53, pp.1113-1118, 2006.
     連結：
130. [142] Majid Mohammadhosseini and Mohammad Saber Tehrani, “Solid phase extraction and determination of trace amounts of Lead (ІІ) using octadecyl membrane disks modified by a new Schiff’s base and flame atomic adsorption spectrometry”, Journal of the Chinese chemical society, Vol.53, pp.1119-1128, 2006.
     連結：
131. [143] Golamreza Khayatian, Hadi Rezatabar, Fatemeh Salehy Karonian, and Abdollah Salimi, “Triiodide ion-selective electrode based on charage-transfer complex of 4,7,13,16,21, 24-hexaoxa-1, 10- diazabicyclo-[8.8.8]hexacosane”, Journal of the Chinese chemical society, Vol.53, pp.1133-1139, 2006.
     連結：
132. [144] Mohammad Reza Ganjali, Parviz Norouzi, and Mehdi Emami, “Novel cesium membrane sensor based on a cavitand”, Journal of the Chinese chemical society, Vol.53, pp.1209-1214, 2006.
     連結：
133. [145] David N. Reinhoudt, “Transduction of molecular recognition into electronic signals”, Recueil des Travaux Chimiques des Pays-Bas, Vol. 115, pp.109–118, 1996.
     連結：
134. [146] Jeong-Do Kim, Hyung-Gi Byun, Dong-Jin Kim, Yu-Kyung Ham, Woo-Suk Jung, and Chul-Oh Yoon, “A simple taste analyzing system design for visual and quantitative analysis of different tastes using multi-array chemical sensors and pattern recognition techniques”, Talanta, Vol.70, pp.546-555, 2006.
     連結：
135. [147] Zhiren Xia, Ibrahim H. A. Badr, Shawn L. Plummer, Lawrence Cullen, and Leonidas G. Bachas, ”Synthesis and evaluation of a bis(crown ether)ionophore with a conformationally constrained bridge in ion-Selective electrodes”, Analytical sciences, Vol.14, February, pp.169-173, 1998.
     連結：
136. [148] G. Hogg, O. Lutze, and K. Cammann, ”Novel membrane material for ion-selective field-effect transistors with extended lifetime and improved selectivity”, Analytica Chimica Acta, 335, pp.103-109, 1996.
     連結：
137. [150] S. Wakida, T. Oizaki, M. Yamane, and K. Higashi, “A preliminary application of highly sensitive nitrate ISFETs to acid-rain monitoring”, Sensors and Actuators B, Vol. 24-25, pp.222-224, 1995.
     連結：
138. [19] Dong Sik Sakong, Min Jong Cha, Jae Ho Shin, Geun Sig Cha, Min Su Ryu, Robert Hower, and Richard B. Brown, “Asymmetric membrane-based potentiometric solid-state ion sensors”, Sensors and Actuators B, Vol. 32, pp.161-166, 1996.
139. [65] Jung Chuan Chou, Kai Ye Huang, and Jin Sung Lin, “Simulation of time-dependent effects of pH-ISFETs”, Sensors and Actuators B, Vol. 62, pp.88-91, 2000.
140. [70] Luc Bousse, H. H. Van Den Vlekkert, and N. F. DE. Rooij, “Hysteresis in AL2O3-gate ISFETs”, Sensors and Actuators B, Vol. 2, pp.103-110, 1990.
141. [72] Aine Garde, John Alderman, and William Lane, “Improving the drift and hysteresis of the Si3N4 pH response using RTP techniques”, Sensors and Materials, Vol. 9, No. 1, pp.15-23, 1997.
142. [84] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, Shen-Kan Hsiung, and Hui-Ling Kao, “Study on the hysteresis for the all-solid-state potassium electrode and the calibration method.”, 2008 International Symposium on Biomedical Engineering (ISOBME), December 12-13, 2008, Taoyuan, Taiwan.
143. [94] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, Shen-Kan Hsiung, and Hui-Ling Kao, “Study on all-solid-state chloride sensor based on tin oxide (SnO2)/ indium tin oxide (ITO) glass.”, Japanese Journal of Applied Physics, Vol. 50, No. 3, pp. 037001, 1-8, 2011.
144. [107] N. Noury, P. Barralon, G. Virone, P. Boissy, M. Hamel, and P. Rumeau, “A smart sensor based on rules and its evaluation in daily routines.”, Engineering in Medicine and Biology Society, Vol. 4, pp.3286-3289 2003.
145. [114] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, Shen-Kan Hsiung, “Study on the multi-sensing system based on the wireless communication technology.”, The 11th International Meeting on Chemical Sensors (IMCS), July 16-19, 2006, Brescia, Italy, pp.1-2.
146. [115] Jui-Fu Cheng, Jung-Chuan Chou, Tai-Ping Sun, Shen-Kan Hsiung, Hui-Ling Kao, “A wireless multi-ion sensing system based on the bluetooth module communication technology.”, 2010 Annual Conference of Chemical Sensors (ACCS), May 23, 2010, Tainan, Taiwan, pp.304-308.
147. [118] Alexey E. Shvarev, Dmitrity A. Rantsan, and Konstantin N. Mikhelson, “Potassium-selective conductometric sensor”, Sensors and Actuators B, Vol. 76, pp. 500-505, 2001.
148. [122] Alexey E. Shvarev, Dmitrity A. Rantsan, and Konstantin N. Mikhelson, “Potassium-selective conductometric sensor”, Sensors and Actuators B, Vol. 76, pp. 500-505, 2001.
149. [133] Chu Neng Tsai, Jung Chuan Chou, Tai Ping Sun, and Shen Kan Hsiung, “Study on the drift calibration method and device for the tin oxide pH electrode”, Rare Metal Materials and Engineering Supplement 3, Vol. 35, pp.210-213, 2006.
150. [149] Z. M. Baccar, N. Jaffrezic-Renault, C. Martelet, H. Jaffrezic, G. Marest, and A. Plantier, “K+ ISFET type microsensors fabricated by ion implantation”, Materials Chemistry and Physics, Vol. 48, pp.56–59, 1997.