题名

極重度新冠肺炎之中醫會診病例報告

并列篇名

A Case Report: Chinese Medicine Consultation for Critical Coronavirus Disease (COVID-19)

DOI

10.6516/TJTCM.202203/SP_25.0015

作者

林家琳(Chia-Lin Lin);王明仁(Ming-Jen Wang);陳朝宗(Chao-Tsung Chen)

关键词

新冠肺炎 ; 急性呼吸窘迫症候群 ; 呼吸衰竭 ; 呼吸器 ; 中醫藥 ; Coronavirus disease COVID-19 ; acute respiratory distress syndrome ; respiratory failure ; ventilator ; traditional Chinese medicine

期刊名称

中醫藥研究論叢

卷期/出版年月

25卷特刊(2022 / 03 / 05)

页次

115 - 136

内容语文

繁體中文

中文摘要

78歲女性,無任何慢性疾病或手術史,2021年06月09日因呼吸道感染症狀至聯合醫院仁愛院區求診,隨即確診新冠肺炎,收治於普通專責病房。住院10天後於2021年06月20日,因呼吸衰竭及血氧飽和濃度低下而插管轉至加護病房治療。西醫依照治療指引給予抗病毒藥物、類固醇與廣效抗生素。入住加護病房次日便於2021年06月21日應家屬要求,會診中醫。中醫以清熱解毒、化濁利濕、清肺排痰、理氣和中,使氣機通暢為主要治則。由於新冠肺炎病人的緣故,中醫四診可行性受到大幅的限制,故需輔以抽血檢查與X光影像協助辨症。中醫介入治療至2021年07月07日共歷時17日。病人於2021年07月12日成功脫離呼吸器並轉入普通病房,於07月29日順利出院,而後固定回胸腔內科回診,且持續追蹤未發現有嚴重後遺症。從這個案例,我們展示新冠肺炎重症病人中醫早期介入的益處。我們同時也說明血液生化檢查、胸腔X光與動脈血氧分析如何輔助新冠肺炎中醫治療,並且用於檢視中醫介入後的療效,希冀可做為未來中醫會診同類型病人的參考指標。

英文摘要

A 78-year-old woman with no notable medical history came to Taipei City hospital Ren-Ai branch seeking medical treatment on 2021/06/09 due to symptoms of respiratory tract infection. She was diagnosed with COVID-19 and admitted to our coronavirus ward. 10 days after admission, the patient developed respiratory failure with low oxygen saturation levels and was promptly intubated and transferred to the intensive care unit. Antiviral agents, systemic corticosteroids and broad spectrum antibiotics were prescribed in accordance to available guidelines. Traditional Chinese medicine (TCM) was consulted at the request of the patient's family members and treatment was initiated on 2021/06/21. The TCM principle of treatment included clearing heat and promoting diuresis, resolving dampness with aromatics, invigorating spleen and regulating stomach to facilitate qi-flowing. Due isolation requirements of COVID patients, the utilization of the four diagnostics methods of TCM were severely limited, so bloods exams and chest x-rays were crucial to guiding the prescription of TCM. TCM treatment was provided simultaneously with standard treatment of COVID-19 until 2021/07/07 for a total of 17 days. The patient was successfully extubated and transferred back to a normal ward on 2021/07/12. She was discharged on 2021/07/29 and has returned regularly to our chest medicine outpatient department for appointments ever since. Continuous follow up of the patient showed that she did not have any sequelae often seen in patients recovering from COVID-19. From this case, we demonstrated how early TCM intervention could help patients with severe COVID-19 infection. We illustrated how diagnostics tests including hemograms, biochemistries, chest x-rays and arterial blood gases could aid in the prescription of TCM for COVID-19 patients, as well as serve as parameters for observation of the therapeutic benefits. We hope this case could serve as a reference for similar patients encountered during TCM consult in the future.

主题分类 醫藥衛生 > 中醫藥學
醫藥衛生 > 藥理醫學
参考文献
  1. 張哲儒,李威毅,黃頌儼,羅綸謙,柯富揚,孫茂峰,楊仁宏(2020)。中醫在 SARS 及 COVID-19 嚴重流行疫病臨床應用之系統性回顧。中醫藥雜誌,32(2),28-30。
    連結:
  2. 許詠棠,葉金川,洪裕強(2020)。新型冠狀病毒肺炎中醫瘟疫試治。中醫內科醫學雜誌,8(2),12-34。
    連結:
  3. 黃靖鈞,吳孟珊,陳忠仁(2020)。結合中西醫理論探討新冠肺炎的病程進展及治療展望。中醫藥研究論叢,23(2),93-115。
    連結:
  4. 衛生福利部疾病管制署。
  5. 深耕中醫藥研究(2021)衛生福利部國家中醫藥研究所,取自 https://www.cna.com.tw/news/ahel/202006100092.aspx
  6. Arons, MM,Hatfield, KM,Reddy, SC,Kimball, A,James, A,Jacobs, JR,Taylor, J,Spicer, K,Bardossy, AC,Oakley, LP,Tanwar, S,Dyal, JW,Harney, J,Chisty, Z,Bell, JM,Methner, M,Paul, P,Carlson, CM,McLaughlin, HP,Thornburg, N,Tong, S,Tamin, A,Tao, Y,Uehara, A,Harcourt, J,Clark, S,Brostrom-Smith, C,Page, LC,Kay, M,Lewis, J,Montgomery, P,Stone, ND,Clark, TA,Honein, MA,Duchin, JS,Jernigan, JA,Public Health–Seattle and King County and CDC COVID-19 Investigation Team(2020).Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility.N Engl J Med,382(22),2081-2090.
  7. Boehmer, TK,DeVies, J,Caruso, E(2020).Changing Age Distribution of the COVID-19 Pandemic-United States, May-August 2020.MMWR Morb Mortal Wkly Rep,69,1404-1409.
  8. Britos, M,Smoot, E,Liu, KD,Thompson, BT,Checkley, W,Brower, RG(2011).The value of positive end-expiratory pressure and FiO2 criteria in the definition of the acute respiratory distress syndrome.Crit Care Med,39,2025-2030.
  9. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses(2020).The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2.Nat Microbiol,5(4),536-544.
  10. David, Berlin A,Gulick, Roy M,Martinez, Fernando J.(2020).Severe Covid-19, The New England Journal of Medicine.The New England Journal of Medicine,383(25),2451-2460.
  11. Dougan, M(2021).Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19.N Engl J Med,385(15),1382-1392.
  12. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention(2020).The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China.Zhonghua Liu Xing Bing Xue Za Zhi,41(2),145-151.
  13. Ferguson, ND,Frutos-Vivar, F,Esteban, A(2005).Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions.Crit Care Med,33,2228-2234.
  14. Ferguson, ND,Meade, MO,Hallett, DC,Stewart, TE(2002).High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome.Intensive Care Med,28,1073-1077.
  15. Group, R.C.(2021).,未出版
  16. Group, R.C.(2020).Dexamethasone in Hospitalized Patients with Covid-19-Preliminary Report.N Engl J Med
  17. Hoffmann, M.(2020).SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.Cell,181(2),271.
  18. Kangelaris, Kirsten Neudoerffer(2014).Is there still a role for the lung injury score in the era of the Berlin definition ARDS?.Annals of intensive care,4,14.
  19. Klompas, M,Baker, MA,Rhee, C(2020).Airborne Transmission of SARS-CoV-2: Theoretical Considerations and Available Evidence.JAMA
  20. Matthay, M. A.,Zemans, R. L.(2011).The acute respiratory distress syndrome: pathogenesis and treatment.Annual review of pathology,6,147-163.
  21. Meyerowitz, EA,Richterman, A,Gandhi, RT,Sax, PE(2021).Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors.Ann Intern Med,174(1),69.
  22. Onder, G,Rezza, G,Brusaferro, S(2020).Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy.JAMA,323(18),1775.
  23. Perlman, S(2020).Another Decade, Another Coronavirus.N Engl J Med,382(8),760.
  24. Petrilli, CM,Jones, SA,Yang, J,Rajagopalan, H,O'Donnell, L,Chernyak, Y,Tobin, KA,Cerfolio, RJ,Francois, F,Horwitz, LI(2020).Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study.BMJ,369,m1966.
  25. Ranieri, VM,Rubenfeld, GD,Thompson, BT(2012).Acute respiratory distress syndrome: the Berlin Definition.JAMA,307,2526-2533.
  26. Ray, JG,Schull, MJ,Vermeulen, MJ,Park, AL(2021).Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness : A Population-Based Cohort Study.Ann Intern Med,174(3),308.
  27. Shankar-Hari, M.(2021).Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.Jama,326(6),499-518.
  28. Shi, Heshui(2020).Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study.Lancet Infect Dis,20(4),425-434.
  29. Terpos, E.(2021).Hematological findings and complications of COVID-19.American Journal of Hematology,95(7),834-847.
  30. Tomazini, B.M.(2020).Effect of Dexamethasone on Days Alive and VentilatorFree in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.JAMA,324(13),1307-1316.
  31. Tsai, Keng-Chang(2021).A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study.Biomedicine & Pharmacotherapy,133,111037.
  32. Vincent, C.,Marconi, A.V.R.,de Bono, Stephanie,Kartman, Cynthia E.,Krishnan, Venkatesh(2021).,未出版
  33. Weinreich, D.M.(2021).REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.N Engl J Med,384(3),238-251.
  34. Weinreich, DM,Sivapalasingam, S,Norton, T(2021).REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19.N Engl J Med
  35. Wheeler, AP,Bernard, GR,Thompson, BT(2006).Pulmonaryartery versus central venous catheter to guide treatment of acute lung injury.N Engl J Med,354,2213-2224.
  36. World Health Organization. Tracking SARS-CoV-2 variants,取自 https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/
  37. Yancy, CW,Jessup, M(2013).ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.Circulation,128(16),e240-e327.
  38. Yang, MQ,Song, YM,Gao, HY,Xue, YT(2019).Efficacy and Safety of Fuzi Formulae on the Treatment of Heart Failure as Complementary Therapy: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials.Evid Based Complement Alternat Med,2019,9728957.
  39. Zhou, P.(2020).A pneumonia outbreak associated with a new coronavirus of probable bat origin.Nature,579(7798),270.
  40. Zhu, N.(2020).A Novel Coronavirus from Patients with Pneumonia in China, 2019.N Engl J Med,382(8),727.
  41. 中國科學院,廣東省中醫院中西醫結合治療「非典」,取自 http://www.cas.cn/zt/kjzt/zykfd/zl/200305/t20030513_1711484.shtml
  42. 中國國家衛生健康委員會,新型冠狀病毒肺炎診療方案(試行第七版),取自 http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml
  43. 張霆(2003)。戾氣為患,邪伏膜原-試論傳染性非典型肺炎之病因病機治療。天津中醫學院學報,22(3),58-60。
  44. 楊宏麗(2020)。審因論治在新冠肺炎中醫診療中的運用。遼寧中醫雜誌
  45. 葉天士(2019).溫熱論.學苑出版社.
  46. 衛生福利部疾病管制署。新型冠狀病毒(SARS-CoV-2)感染臨床處置暫行指引第十四版,取自 https://www.cdc.gov.tw/Category/Page/xCSwc5oznwcqunujPc-qmQ
  47. 衛生福利部疾病管制署。新型冠狀病毒 SARS-CoV-2 感染臨床處置暫行指引第十四版,取自 https://www.cdc.gov.tw/File/Get/CO6RFopMVJvsUgEHUs4Uiw
  48. 衛生福利部國家中醫藥研究所,新型冠狀病毒(新冠肺炎)中醫會診分期治療指引,取自 https://www.nricm.edu.tw/p/406-1000-6141,r11.php?Lang=zh-tw
  49. 蘇奕彰(2021):臺灣清冠一號(NRICM101)處方依據、方解和基礎研究,衛生福利部國家中醫藥研究所。取自 https://www.nricm.edu.tw/p/406-1000-6497,r51.php