傳統中醫多元整合治療對乳癌病患西醫治療後副作用的緩解成效：回顧性研究

The Effectiveness of Traditional Chinese Medicine Multiple Integrational Treatment for the Management of Therapy-Related Adverse Events in Patients with Breast Cancer: A Retrospective Study

10.6516/TJTCM.202206_25(2).0001

吳勇璋(Yung-Chang Wu)；吳修安(Hsiu-An Wu)；陳建宏(Chien-Hung Chen)；謝明憲(Ming-Hsien Hsieh)；邱榮鵬(Jung-Peng Chiu)；鄭鳳翔(Feng- Shiang Cheng)；許中華(Chung-Hua Hsu)

中醫 ； 乳癌 ； 副作用 ； traditional Chinese medicine ； breast cancer ； therapy-related adverse events acupuncture

中醫藥研究論叢

25卷2期（2022 / 06 / 30）

1 - 15

繁體中文

目的：本研究以病歷回溯方式分析在接受西醫治療的乳癌病患，以傳統中醫多元整合模式介入後，運用常見毒性標準量表（Common Terminology Criteria for Adverse Events, CTCAE）、台灣版簡明疲憊量表（Brief Fatigue Inventory-Taiwan Form, BFI-T）、台灣簡明版世界衛生組織生活品質量表（WHOQOL-BREF），分析其西醫治療副作用的緩解程度。方法：收錄於2017年6月至2019年11月於林森中醫昆明院區癌症日間延長照護門診接受中醫治療的乳癌病人（符合癌（ICD-10：C50.0-C50.929）之診斷）的所有病歷，排除無法完成量表或紀錄不全的資料，使用IBM SPSS統計軟體VERSION21對問卷結果進行成對樣本t檢定與廣義估計方程式（Generalized estimating equations）分析。結果：發現每次收案的治療次數超過10次的，與疾病較嚴重的後期病患（3-4期），有較好的治療成效，他們的CTCAE減少分數與疲倦改善程度均較另一組來的多，雖然兩組差異在統計上沒有達到顯著意義。使用廣義估計方程式的分析後，發現CTCAE的下降，與台灣簡明版世界衛生組織生活品質量表（WHOQOL-BREF）改善分數呈正相關，與每位病患收案的次數呈負相關。結論：以傳統中醫多元整合模式介入西醫治療中的乳癌病患，對於後期且每次收案治療次數大於10次的病患，較能緩解西醫治療造成的副作用與改善生活品質，但仍需有更大規模的收案與進一步的研究來支持此結論。

The effectiveness of traditional Chinese medicine treatment for the management of therapy-related adverse events in patients with breast cancer will be confirm in this study. The results were evaluated by common terminology criteria for adverse events (CTCAE), brief fatigue inventory-Taiwan form (BFI-T), world health organization quality of life questionnaire (WHOQOL-BREF). We collected the data from June 2017 to November 2019, then analyze by paired sample t-test and generalized estimating equations. Patient received more than 10 treatments each period and late stage (stage 3-4) had better benefit. Reduction of CTCAE score and fatigue improvement were better than the other group, although there was not statistically significant. It means TCM could improve the adverse effects in patient with breast cancer. However, more large-scale acceptance and further research are necessary to support our study.

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