题名

針藥並用輔助治療乳癌末期蕈狀傷口潰爛膿血之病例報告

并列篇名

The Therapeutic Experience of Malignant Fungating Wounds in End-Stage Breast Cancer with Traditional Chinese Medicine and Acupuncture-A Case Report

DOI

10.6516/TJTCM.202303_26(1).0003

作者

陳豪君(Hao-Chun Chen)

关键词

乳癌末期 ; 蕈狀傷口 ; 腫瘤 ; 化療副作用 ; 中醫 ; 針灸 ; 癌症輔助治療 ; Breast cancer ; Malignant Fungating Wounds ; Tumor ; Side effects of chemotherapy ; Complementary and alternative medicine ; Traditional Chinese medicine (TCM) ; Acupuncture

期刊名称

中醫藥研究論叢

卷期/出版年月

26卷1期(2023 / 03 / 30)

页次

29 - 41

内容语文

繁體中文;英文

中文摘要

48歲女性左側乳房腫塊兩年但不願就醫,前年1月乳房腫塊開始變大變硬,而後開始觸摸到左側腋下腫塊,但此時患者仍不願就醫,自行以網路偏方治療,直到去年四月乳房腫塊上皮膚開始滲出膿液,再半年後因乳房腫塊疼痛、虛弱、眠差、納差、體重減輕才於2021/09/28才第一次至西醫就診,就診時乳房腫塊已8公分,腫瘤皮膚蕈狀傷口潰瘍流膿血、肉芽組織範圍已達10cmx10cm,診斷為左側侵襲性乳管癌(T4bN2M1, Stage IV)合併淋巴結轉移,影像學上並已有肺部轉移,無法開刀。2021/10/18裝置port-A開始化療,第一次Docetaxel、第二次Docetaxel化療+Trastuzumab、Pertuzumab標靶完成後,因腫塊仍持續流膿血及化療副作用水瀉頻急而於2021/11/20至中醫門診就診,伴隨疲倦、納差、夜間眠差難入睡易醒、情緒緊張、胸悶心悸,兩耳耳鳴悶塞感、口乾口苦、雙手十指紅疹癢、小便頻而黃…等症狀,經中醫辨證為肝鬱氣滯化熱痰凝乳絡、化療後脾胃氣虛濕聚,經治以益氣健脾、疏肝清熱,用藥二個多月後患者左側乳房腫塊皮膚潰破收口,範圍縮小至6.5cmx5.5cm,且已無膿血滲出。

英文摘要

Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer. Care usually aims to slow down disease progression, and improve quality of life by relieving the physical symptoms caused by the wounds (leakage, bad smell, pain and the risk of haemorrhage). This case is about a 48-year-old woman who has locally advanced invasive ductal carcinoma with lung metastasis and lymph nodes metastasis with a fungating malignant wound on her left breast. After 2^(nd) chemotherapy, the skin ulceration was still oozing and painful and the chemotherapy-related diarrhea, fatigue, poor-appetite, hair loss, insomnia, anemia and palpitation were also noticed. With sink pulsation and the above symptoms, the major diagnosis in traditional Chinese medicine is "liver qi stagnation and dampness-heat congestion" and "spleen and kidney deficiency". After benefiting spleen qi, dispersing stagnated liver qi and reducing the damp and heat, the fungating malignant wound has shrunk from 10 cm to 6.5 cm in diameter and no longer oozing within two months treating with acupuncture and traditional Chinese medicine. Also, the chemotherapy-related diarrhea in the 3^(rd) chemotherapy was reduced.

主题分类 醫藥衛生 > 中醫藥學
醫藥衛生 > 藥理醫學
参考文献
  1. 黃碧松,賴振源(2014)。乳癌臨床診治思維。傳統醫學雜誌,25(1),63-91。
    連結:
  2. 黃碧松,賴振源(2014)。乳癌臨床診治思維。傳統醫學雜誌,25(1),63-91。
    連結:
  3. 廖麗蘭,許中華(2017)。乳癌中西醫療法的探討。中醫內科醫學雜誌,15(1),11-27。
    連結:
  4. 認識乳癌化學治療之Taxotere。高雄市立小港醫院(委託財團法人高雄醫學大學經營)。2008.12取自:https://www.kmsh.org.tw/hygr_Edu/hygr/20180306137.pdf
  5. 109 年死因結果分析(含附表)。衛生福利部。2021; 1-7.。https://www.mohw.gov.tw/dl-71446-e142a47c-14b3-4cef-8d80-f8e5747e8eb2.html
  6. 108 年癌症登記報告。衛生福利部國民健康署。2021;70-71.https://www.hpa.gov.tw/Pages/ashx/File.ashx?FilePath=~/File/Attach/14913/File_18302.pdf
  7. Alexander, S(2009).Malignant fungating wounds: epidemiology, aetiology, presentation and assessment.J Wound Care,18(7),273-280.
  8. Alexander, S.(2009).Malignant fungating wounds: key symptoms and psychosocial.J Wound Care,18(8),325-329.
  9. Balduzzi, S.,Mantarro, S.,Guarneri, V.,Tagliabue, L.,Pistotti, V.,Moja, L.,D'Amico, R.(2014).Trastuzumab-containing regimens for metastatic breast cancer.Cochrane Database Syst Rev,2014(6),CD006242.
  10. Baselga, J.,Cortés, J,Kim, S.B.,Im, S.A,Hegg, R.,Im, Y.H.,Roman, L.,Pedrini, J.L.,Pienkowski, T,Knott, A.,Clark, E.,Benyunes, M.C,Ross, G.,Swain, S.M.,CLEOPATRA Study Group(2012).Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer.N Engl J Med.,366(2),109-119.
  11. Chlebowski RT. Factors that modify breast cancer risk in women. UpToDate. 2021. 1-31.
  12. Colon-Echevarria, CB,Lamboy-Caraballo, R,Aquino-Acevedo, AN,Armaiz-Pena, GN(2019).Neuroendocrine Regulation of Tumor-Associated Immune Cells.Front Oncol,9,1077.
  13. Grocott, P(1995).The palliative management of fungating malignant wounds.J Wound Care,4(5),240-242.
  14. Hirst, DG(1992).Annual report of the Cancer Research Campaign Grey LaboratoryAnnual report of the Cancer Research Campaign Grey Laboratory,未出版
  15. Joe BN. Clinical features, diagnosis, and staging of newly diagnosed breast cancer. UpToDate. 2021. 1-34.
  16. Morison, M.(ed.),Moffatt, C.(ed.),Bridel Nixon, J.(ed.),Bale, S(ed.)(1997).Nursing Management of Chronic Wounds.London:Mosby.
  17. Sung, H,Ferlay, J,Siegel, RL,Laversanne, M,Soerjomataram, I,Jemal, A,Bray, F(2021).Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.CA Cancer J Clin,71(3),209-249.
  18. Swain, S.M,Baselga, J.,Kim, S.B.,Ro, J.,Semiglazov, V.,Campone, M.,Ciruelos, E.,Ferrero, J.M.,Schneeweiss, A.,Heeson, S.,Clark, E.,Ross, G.,Benyunes, M.C,Cortés, J.,CLEOPATRA Study Group(2015).CLEOPATRA Study Group. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer.N Engl J Med.,372(8),724-734.
  19. 王執中。王執中(1220):針灸資生經。中醫笈成資料庫。2021更新。取自:https://jicheng.tw/tcm/book/%E9%87%9D%E7%81%B8%E8%B3%87%E7%94%9F%E7%B6%93/index.html。https://jicheng.tw/tcm/book/%E9%87%9D%E7%81%B8%E8%B3%87%E7%94%9F%E7%B6%93/index.html
  20. 朱震亨。朱震亨(1347):格致餘論。中醫笈成資料庫。2021更新。取自:https://jicheng.tw/tcm/book/%E6%A0%BC%E8%87%B4%E9%A4%98%E8%AB%96/index.html。https://jicheng.tw/tcm/book/%E6%A0%BC%E8%87%B4%E9%A4%98%E8%AB%96/index.html
  21. 朱震亨,高叔宗(輯校)。朱震亨原著、高叔宗輯校(1543):丹溪治法心要。中醫笈成資料庫。2021更新。取自:https://jicheng.tw/tcm/book/%E4%B8%B9%E6%BA%AA%E6%B2%BB%E6%B3%95%E5%BF%83%E8%A6%81/index.html。https://jicheng.tw/tcm/book/%E4%B8%B9%E6%BA%AA%E6%B2%BB%E6%B3%95%E5%BF%83%E8%A6%81/index.html
  22. 余景和(編輯),尚冰(校註)(2015).外證醫案匯編.北京:中國中醫藥出版社.
  23. 吳金娜,韓向暉,葉依依,黃曼,劉勝(2013)。桔梗配伍不同治則中藥對乳腺癌肺轉移的影響。癌症進展,11(2),159-167。
  24. 吳謙(2011).醫宗金鑒.山西:山西科學技術出版社.
  25. 李軍,王鏡輝,王倩,王慶學,羅莉,唐東昕(2018)。乳腺癌中醫診治思路淺析。中國民族民間醫藥,27(15),5-6+32。
  26. 巢元方。巢元方(614):諸病源候論。中醫笈成資料庫。2021更新。取自:https://jicheng.tw/tcm/book/%E8%AB%B8%E7%97%85%E6%BA%90%E5%80%99%E8%AB%96/index.html。https://jicheng.tw/tcm/book/%E8%AB%B8%E7%97%85%E6%BA%90%E5%80%99%E8%AB%96/index.html
  27. 郭栴子,朱中博,楊碩,楊燕瑩,黃芊,李康樂,竇建衛(2020)。乳腺癌之情志論。遼寧中醫雜誌,47(12),71-73。
  28. 陳實功。陳實功(1617):外科正宗。中醫笈成資料庫。2021更新。取自:https://jicheng.tw/tcm/book/%E5%A4%96%E7%A7%91%E6%AD%A3%E5%AE%97/index.html。https://jicheng.tw/tcm/book/%E5%A4%96%E7%A7%91%E6%AD%A3%E5%AE%97/index.html
  29. 楊繼州(1994).針灸大成.台北:大中國圖書公司.
  30. 薛己。薛己(1237):校註婦人良方。中醫笈成資料庫。2021更新。取自:https://jicheng.tw/tcm/book/%E6%A0%A1%E8%A8%BB%E5%A9%A6%E4%BA%BA%E8%89%AF%E6%96%B9/index.html。https://jicheng.tw/tcm/book/%E6%A0%A1%E8%A8%BB%E5%A9%A6%E4%BA%BA%E8%89%AF%E6%96%B9/index.html