腎臟移植的誘導治療

Induction Therapy in Kidney Transplantation

10.6340/KD.2016.28(1).02

邱顯富(Hsien-Fu Chiu)；吳明儒(Ming-Ju Wu)；鄭志雄(Chi-Hung Cheng)；徐國雄(Kuo-Hsiung Shu)

腎臟移植 ； 誘導治療 ； 免疫抑制藥物 ； kidney transplantation ； induction therapy ； immunosuppressant agents

腎臟與透析

28卷1期（2016 / 03 / 01）

5 - 9

繁體中文

腎臟移植的免疫抑制治療分為三大項目：誘導治療、維持治療、以及排斥治療。本篇的目的是介紹誘導治療。誘導治療藥物根據作用機轉可分為T細胞消除藥物(T-cell depleting agents)、B細胞與T細胞消除藥物(Band T-cell depleting agents)、非消除性T細胞藥物(nondepleting T-cell agents)。此篇文章將介紹近年內研發的誘導治療藥物，各種藥物的藥理特性、常見的副作用以及如何根據病患的狀況選擇適當的誘導治療藥物。

Currently immunosuppressive agents for kidney transplantation can be classified into three categories: induction agents, maintenance therapy, and treatment for rejection. This article is focused on induction therapy. Induction agents can be defined as T-cell depleting, B- and T-cell depleting, and nondepleting T-cell agents. We will focus on the pharmacology, efficacy, major side effects including infection and malignancy, and how to choose an appropriate induction regimen for individualized kidney recipients according to risk and benefit assessment.