鼻咽癌的家族聚集及多因子遺傳分析

Familial Aggregation and Multifactorial Inheritance of Nasopharyngeal Carcinoma

10.6288/CJPH1994-13-01-08

許芳源(Fang-Yuan Hsu)；徐茂銘(Mow-Ming Hsu)；鄭玉娟(Yu-Juen Cheng)；陳建仁(Chien-Jen Chen)

Nasopharyngeal carcinoma ； Familial aggregation ； Multifactorial inheritance

中華公共衛生雜誌

13卷1期（1994 / 02 / 01）

88 - 94

繁體中文

為探討鼻咽癌的家族聚集及多因子遺傳度，本研究對台大醫院耳鼻喉科1001名鼻咽癌病例，進行家族成員鼻咽癌盛行狀況的結構式問卷訪視：並且進一步以電話複訪438名居住大台北地區的鼻咽癌病例，以獲得更詳盡的一等親鼻咽癌發病資料。研究結果顯示，1001名鼻咽癌指標病例之父母、兄弟姐妹、祖父母、伯叔姑舅姨、和配偶的每千人口鼻咽癌盛行率分別是14.5、115、2.4、3.7、和1.0。根據上述一等親和二等親的盛行狀況，可推算鼻咽癌的多因子遺傳度±標準誤為0.50±0.02。根據438名大台北地區鼻咽癌指標病例之父母和兄弟姐妹的年齡別鼻咽癌累積發生率，推算鼻咽癌的多因子遺傳度±標準誤則為0.51±0.04。

In order to assess the familial aggregation and multifactorial inheritance of nasopharyngeal carcinoma (NPC), a total of 1,001 index NPC cases were recruited from the Department of Otolaryngology, National Taiwan University Hospital. NPC status of family members were inquired through standardized interviews based on a structured questionnaire. Telephone interviews were further carried out to obtain cumulative NPC incidence among first-degree relatives of 438 index cases resided in metropolitan Taipei. The NPC prevalence was found to be 14.5, 11.5, 2.4, 3.7 and 1.0 per 1,000, respectively, for parents, sibling, grandparents, uncles and aunts, as well as spouses of NPC index cases. The multifactorial inheritance index ± standard error of NPC based on the prevalence were 0.50±0.02. Cumulative NPC incidence rates were significantly higher among parents and siblings of NPC cases than those for the general population in Taipei. The cumulative incidence-derived multifactorial inheritance index ± standard error of NPC were 0.51±0.04.