有氧運動訓練對能量代謝路徑與腎功能之影響

Effects of Aerobic Exercise Training on Regulation of Renal Energy Metabolism by Activating Energy Metabolism Pathway in Diabetic db/db

10.6406/JNCKUPER.201810_50(2).0001

高浩瀚(Kao Hao-Han)

腎病變 ； SIRT1 ； AMPKα ； PGC1-α ； Diabetic Nephropathy ； SIRT1 ； AMPKα ； PGC1-α

成大體育學刊

50卷2期（2018 / 10 / 01）

1 - 15

繁體中文

糖尿病腎病變是糖尿病患者最主要之併發症及死因，也是目前國內高發生率、盛行率、醫療花費的重要疾病。Sirtuin 1（SIRT1）、AMP-activated protein kinase（AMPK）蛋白、及peroxisome proliferator-activated receptor gamma coactivator 1-α（PGC1-α），在細胞內調節能量代謝和粒線體功能扮演重要樞紐，臨床上證實早期規律運動可以延緩早期糖尿病腎病變，避免病症繼續惡化，然而，以運動訓練經由AMPKα/SIRT1/PGC1α路徑調控粒線體功能來改善糖尿病腎病變的直接證據，目前還不清楚。目的：本文欲針對糖尿病能量代謝失衡以及運動訓練預防糖尿病腎病變分子機制等部分，進行相關文獻的剖析及探討，對於此議題有興趣的讀者作為參考。

Diabetic nephropathy is one of the leading complications and cause of death of diabetic patients. It is also a major domestic disease that has high incidence rate, high prevalence rate as well as high health expenditure. Sirtuin 1 (SIRT1), AMP-activated protein, kinase (AMPK) protein and peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1-α) plays a crucial role in regulating the energy metabolism and mitochondrial function within a cell. Periodic and long term aerobic exercises can improve early stages of diabetic nephropathy, preventing symptoms from deteriorating. However, there is still lack of evidence to support the theory of utilizing exercises to regulate mitochondrial function in order to improve diabetic nephropathy via the route of AMPKα/SIRT1/PGC1α. Research Purpose: The main context of this thesis is to analyze related literature in regards to the imbalance of diabetes energy metabolism, as well as exercise training as prevention to diabetic nephropathy molecular mechanism。Reference for readers interested in this topic.

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