利用心臟電腦斷層影像評估動脈脈搏傳導速度

Estimation of Pulse Wave Velocity Using Cardiac Computer Tomography Image

簡向志(Siang-Jhih Jian)；陳奕瑋(Yi-Wei Chen)；胡威志(Wei-Chih Hu)

心臟斷層影像 ； 區域成長 ； 動態邊緣 ； 脈波傳導速率 ； CT image ； active contour ； seeded region grow ； pulse wave velocity

先進工程學刊

8卷4期（2013 / 10 / 01）

211 - 217

繁體中文

Recent studies have shown that patients who have atherosclerosis would increase the risk of cardiovascular disease directly or indirectly. Total arterial compliance (TAC) is defined as the sum of systemic arterial compliance to estimate the feature of atherosclerosis while Pulse wave velocity (PWV) is an index for clinically assessing the level of artery stiffness in TAC. The purpose of this study is to investigate the volume change in the aortic heart cycle to evaluate the arterial PWV by using 3D cardiac computed tomography images. In this research, Cardiac DICOM images are reconstructed by a self-developed image processing program into 10 frames of 3D cardiac model to inspect data specified and calculated in the DICOM data set for the volume at ROI. In experiment, fifteen subjects' 3D CT cardiograms were collected to calculate the aortic flows, which ranged from 68.91 to 97.54 ml. The data well-correlated with the cardio outputs from the Left Ventricular (LV) image (Aortic Flow = 1.07*Cardio Output-4.082 ml, R^2 = 0.968, p ＜ 0.01). And the PWV was calculated from variation of distance divided by the time difference (Δd/Δs). That was to select the max distention from aortic slices and the distance between the slice and the time difference calculated with the results shown PWVs ranging from 0.714 to 1.548 m/s. Furthermore, the data positively correlated to Total arterial compliance calculated at the aortic root (r = 0.666, p ＜ 0.01). And, the PWV negatively correlated to the distention of aorta (r = -0.8138, p ＜ 0.01). Therefore, this derived methodology could be used to index and calculate PWV from 3D CT cardiac image in evaluating arterial stiffness.

Recent studies have shown that patients who have atherosclerosis would increase the risk of cardiovascular disease directly or indirectly. Total arterial compliance (TAC) is defined as the sum of systemic arterial compliance to estimate the feature of atherosclerosis while Pulse wave velocity (PWV) is an index for clinically assessing the level of artery stiffness in TAC. The purpose of this study is to investigate the volume change in the aortic heart cycle to evaluate the arterial PWV by using 3D cardiac computed tomography images. In this research, Cardiac DICOM images are reconstructed by a self-developed image processing program into 10 frames of 3D cardiac model to inspect data specified and calculated in the DICOM data set for the volume at ROI. In experiment, fifteen subjects' 3D CT cardiograms were collected to calculate the aortic flows, which ranged from 68.91 to 97.54 ml. The data well-correlated with the cardio outputs from the Left Ventricular (LV) image (Aortic Flow = 1.07*Cardio Output-4.082 ml, R^2 = 0.968, p ＜ 0.01). And the PWV was calculated from variation of distance divided by the time difference (Δd/Δs). That was to select the max distention from aortic slices and the distance between the slice and the time difference calculated with the results shown PWVs ranging from 0.714 to 1.548 m/s. Furthermore, the data positively correlated to Total arterial compliance calculated at the aortic root (r = 0.666, p ＜ 0.01). And, the PWV negatively correlated to the distention of aorta (r = -0.8138, p ＜ 0.01). Therefore, this derived methodology could be used to index and calculate PWV from 3D CT cardiac image in evaluating arterial stiffness.